Publications of the Week Targeting the Membrane-Proximal C2-Set Domain of CD33 for Improved CD33-Directed ImmunotherapyGodwin, C.D., et al. | February 22, 2021There is increasing interest in targeting CD33 in malignant and non-malignant disorders. In acute myeloid…kchenFebruary 22, 2021 Read More
Publications of the Week BRCA1/BARD1 Site-Specific Ubiquitylation of Nucleosomal H2A Is Directed by BARD1Witus, S.R., et al. | February 19, 2021Mutations in the E3 ubiquitin ligase RING domains of BRCA1/BARD1 predispose carriers to breast and…kchenFebruary 19, 2021 Read More
Publications of the Week A Curious Case for Development of Kinase Inhibitors as Antigiardiasis Treatments Using Advanced Drug TechniquesMichaels, S. A., et al. | February 19, 2021In this manuscript we discuss emerging drug development tools that can be used to accelerate…emcguinnFebruary 19, 2021 Read More
Publications of the Week T Cells Specific for a Mycobacterial Glycolipid Expand after Intravenous Bacillus Calmette–Guérin VaccinationLayton, E. D., et al. | February 18, 2021Peptide antigens are typically presented to T cells by highly polymorphic major histocompatibility complex (MHC)…emcguinnFebruary 18, 2021 Read More
Publications of the Week Residual β Cell Function in Long-Term Type 1 Diabetes Associates with Reduced Incidence of HypoglycemiaGubitosi-Klug, R., et al. | February 12, 2021We investigated residual β cell function in Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions…emcguinnFebruary 12, 2021 Read More
Publications of the Week Conformation-Dependent Blockage of Activated VWF Improves Outcomes of Traumatic Brain Injury in MiceXu, X., et al. | February 9, 2021Traumatic brain injury-induced coagulopathy (TBI-IC) causes life-threatening secondary intracranial bleeding. Its pathogenesis differs mechanistically from…emcguinnFebruary 9, 2021 Read More
Publications of the Week Rapid Adaptation to Human Protein Kinase R by a Unique Genomic Rearrangement in Rhesus CytomegalovirusChild, S., et al. | February 4, 2021Cytomegaloviruses (CMVs) are generally unable to cross species barriers, in part because prolonged coevolution with…emcguinnFebruary 4, 2021 Read More
Publications of the Week Pleiotropic Mutations Can Rapidly Evolve to Directly Benefit Self and Cooperative Partner Despite Unfavorable ConditionsHart, S., et al. | February 2, 2021Cooperation, paying a cost to benefit others, is widespread. Cooperation can be promoted by pleiotropic…emcguinnFebruary 2, 2021 Read More
Publications of the Week Survey of Spiking in the Mouse Visual System Reveals Functional HierarchySiegle, J., et al. | January 27, 2021The anatomy of the mammalian visual system, from the retina to the neocortex, is organized…emcguinnJanuary 27, 2021 Read More
Publications of the Week Prospective Mapping of Viral Mutations that Escape Antibodies Used to Treat COVID-19Starr, T., et al. | January 26, 2021Antibodies are a potential therapy for SARS-CoV-2, but the risk of the virus evolving to…emcguinnJanuary 26, 2021 Read More