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SUMMARY:Biostatistics Seminar Series
DESCRIPTION:The Fred Hutch Biostatistics Program hosts seminars featuring presentations by Hutch and outside scientists to share their latest developments and recent research. Each seminar includes an hour-long presentation and discussion during which speakers showcase their work and findings. \nThis seminar will be held on Zoom due to the COVID-19 pandemic. \nAbstract: \nThe T cell repertoire is the collection of all the different T cell clones in the immune system. Due to the critical roles that T cells play in multiple diseases\, understanding the dynamics and signatures of the T cell repertoire has become increasingly important. There is a growing consensus that TCR repertoire could be serving as the next important biomarker for disease diagnosis and prognosis. However\, due to the hyper-diversity of the T cell receptors and the lack of knowledge of their antigen-specificities\, the analysis of the TCR repertoire is parable to reading a book without words. Hence\, extracting meaningful information from the TCR repertoire of healthy/diseased individuals has become one of the top priorities. Our lab is committed to developing novel computational methods to investigate human TCR repertoires. In this talk\, I will cover three of our recent methods\, iSMART (Zhang et al.\, 2020\, Clinical Cancer Research)\, DeepCAT (Beshnova et al.\, 2020\, Science Translational Medicine) and GIANA (Zhang et al.\, 2021\, Nature Communications)\, and progressively illustrate how we developed a novel diagnostic biomarker out of the TCR repertoire data for early cancer and other disease detections. \n 
URL:https://scienceinseattle.com/event/biostatistics-seminar-series-5/
LOCATION:Online
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20211110T120000
DTEND;TZID=America/Vancouver:20211110T130000
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LAST-MODIFIED:20211108T174210Z
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SUMMARY:Biostatistics Seminar Series
DESCRIPTION:The Fred Hutch Biostatistics Program hosts seminars featuring presentations by Hutch and outside scientists to share their latest developments and recent research. Each seminar includes an hour-long presentation and discussion during which speakers showcase their work and findings. \nThis seminar will be held on Zoom due to the COVID-19 pandemic. \nAbstract: \nThe T cell repertoire is the collection of all the different T cell clones in the immune system. Due to the critical roles that T cells play in multiple diseases\, understanding the dynamics and signatures of the T cell repertoire has become increasingly important. There is a growing consensus that TCR repertoire could be serving as the next important biomarker for disease diagnosis and prognosis. However\, due to the hyper-diversity of the T cell receptors and the lack of knowledge of their antigen-specificities\, the analysis of the TCR repertoire is parable to reading a book without words. Hence\, extracting meaningful information from the TCR repertoire of healthy/diseased individuals has become one of the top priorities. Our lab is committed to developing novel computational methods to investigate human TCR repertoires. In this talk\, I will cover three of our recent methods\, iSMART (Zhang et al.\, 2020\, Clinical Cancer Research)\, DeepCAT (Beshnova et al.\, 2020\, Science Translational Medicine) and GIANA (Zhang et al.\, 2021\, Nature Communications)\, and progressively illustrate how we developed a novel diagnostic biomarker out of the TCR repertoire data for early cancer and other disease detections. \n 
URL:https://scienceinseattle.com/event/biostatistics-seminar-series-5-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20211110T120000
DTEND;TZID=America/Vancouver:20211110T130000
DTSTAMP:20260822T085948
CREATED:20211108T174210Z
LAST-MODIFIED:20211108T174210Z
UID:26770-1636545600-1636549200@scienceinseattle.com
SUMMARY:Biostatistics Seminar Series
DESCRIPTION:The Fred Hutch Biostatistics Program hosts seminars featuring presentations by Hutch and outside scientists to share their latest developments and recent research. Each seminar includes an hour-long presentation and discussion during which speakers showcase their work and findings. \nThis seminar will be held on Zoom due to the COVID-19 pandemic. \nAbstract: \nThe T cell repertoire is the collection of all the different T cell clones in the immune system. Due to the critical roles that T cells play in multiple diseases\, understanding the dynamics and signatures of the T cell repertoire has become increasingly important. There is a growing consensus that TCR repertoire could be serving as the next important biomarker for disease diagnosis and prognosis. However\, due to the hyper-diversity of the T cell receptors and the lack of knowledge of their antigen-specificities\, the analysis of the TCR repertoire is parable to reading a book without words. Hence\, extracting meaningful information from the TCR repertoire of healthy/diseased individuals has become one of the top priorities. Our lab is committed to developing novel computational methods to investigate human TCR repertoires. In this talk\, I will cover three of our recent methods\, iSMART (Zhang et al.\, 2020\, Clinical Cancer Research)\, DeepCAT (Beshnova et al.\, 2020\, Science Translational Medicine) and GIANA (Zhang et al.\, 2021\, Nature Communications)\, and progressively illustrate how we developed a novel diagnostic biomarker out of the TCR repertoire data for early cancer and other disease detections. \n 
URL:https://scienceinseattle.com/event/biostatistics-seminar-series-5-3/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20211110T180000
DTEND;TZID=America/Vancouver:20211110T190000
DTSTAMP:20260822T085948
CREATED:20211025T174446Z
LAST-MODIFIED:20211025T174446Z
UID:15262-1636567200-1636570800@scienceinseattle.com
SUMMARY:Reimagine Your Immune System
DESCRIPTION:We’ve been hearing a lot about the immune system lately\, but do you really know what it is? Have you been wondering about your own immune system and how to take care of it? \nJoin ISB President Dr. Jim Heath and world-class immunologists on November 10 from 6 – 7 p.m. PT to learn how your immune system works and what steps you can take to improve it. \nReimagine is an annual event that is open to the community. It’s an opportunity to learn about ISB’s science and support our ongoing research efforts. \nA generous group of donors has stepped up to match all donations received up to $20\,000! If you donate before or during the event your gift will be doubled. You can also donate in advance\, and receive a special event package.
URL:https://scienceinseattle.com/event/reimagine-your-immune-system/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20211110T180000
DTEND;TZID=America/Vancouver:20211110T190000
DTSTAMP:20260822T085948
CREATED:20211025T174446Z
LAST-MODIFIED:20211025T174446Z
UID:25799-1636567200-1636570800@scienceinseattle.com
SUMMARY:Reimagine Your Immune System
DESCRIPTION:We’ve been hearing a lot about the immune system lately\, but do you really know what it is? Have you been wondering about your own immune system and how to take care of it? \nJoin ISB President Dr. Jim Heath and world-class immunologists on November 10 from 6 – 7 p.m. PT to learn how your immune system works and what steps you can take to improve it. \nReimagine is an annual event that is open to the community. It’s an opportunity to learn about ISB’s science and support our ongoing research efforts. \nA generous group of donors has stepped up to match all donations received up to $20\,000! If you donate before or during the event your gift will be doubled. You can also donate in advance\, and receive a special event package.
URL:https://scienceinseattle.com/event/reimagine-your-immune-system-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20211110T180000
DTEND;TZID=America/Vancouver:20211110T190000
DTSTAMP:20260822T085948
CREATED:20211025T174446Z
LAST-MODIFIED:20211025T174446Z
UID:26764-1636567200-1636570800@scienceinseattle.com
SUMMARY:Reimagine Your Immune System
DESCRIPTION:We’ve been hearing a lot about the immune system lately\, but do you really know what it is? Have you been wondering about your own immune system and how to take care of it? \nJoin ISB President Dr. Jim Heath and world-class immunologists on November 10 from 6 – 7 p.m. PT to learn how your immune system works and what steps you can take to improve it. \nReimagine is an annual event that is open to the community. It’s an opportunity to learn about ISB’s science and support our ongoing research efforts. \nA generous group of donors has stepped up to match all donations received up to $20\,000! If you donate before or during the event your gift will be doubled. You can also donate in advance\, and receive a special event package.
URL:https://scienceinseattle.com/event/reimagine-your-immune-system-3/
LOCATION:Online
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