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SUMMARY:Distinguished Seminar Series - Corey Hartwell
DESCRIPTION:Development and neural diversity of septal nuclei \nSeptal nuclei in the basal forebrain have critical roles in regulating emotional states including fear\, anxiety\, and aggression. Dysfunction of septal neurons is thought to play a significant role in the pathophysiology of a variety of psychiatric disorders including schizophrenia\, bipolar disorder and depression. The septum can be classified into medial (MS)and lateral (LS) regions. The medial septum is composed of cholinergic\, GABAergic and glutamatergic neurons that primarily project to the hippocampus. The lateral septum is composed of a diverse array of GABAergic projection neurons that have reciprocal connections with numerous brain regions known to regulate emotional and motivational states. It is currently unclear how septal neuronal diversity and circuit wiring are specified during development. Using molecular genetics and single-cell/nuclei RNA-seq we have begun to unravel the developmental logic for producing diverse neural cell types in the septum. Our future work is focused on understanding the specific contribution of developmentally specified neural cell types in the regulation of internal states carried out by the septum.
URL:https://scienceinseattle.com/event/distinguished-seminar-series-corey-hartwell/
LOCATION:Online
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CREATED:20220829T195831Z
LAST-MODIFIED:20220829T195831Z
UID:25930-1663151400-1663155000@scienceinseattle.com
SUMMARY:Distinguished Seminar Series - Corey Hartwell
DESCRIPTION:Development and neural diversity of septal nuclei \nSeptal nuclei in the basal forebrain have critical roles in regulating emotional states including fear\, anxiety\, and aggression. Dysfunction of septal neurons is thought to play a significant role in the pathophysiology of a variety of psychiatric disorders including schizophrenia\, bipolar disorder and depression. The septum can be classified into medial (MS)and lateral (LS) regions. The medial septum is composed of cholinergic\, GABAergic and glutamatergic neurons that primarily project to the hippocampus. The lateral septum is composed of a diverse array of GABAergic projection neurons that have reciprocal connections with numerous brain regions known to regulate emotional and motivational states. It is currently unclear how septal neuronal diversity and circuit wiring are specified during development. Using molecular genetics and single-cell/nuclei RNA-seq we have begun to unravel the developmental logic for producing diverse neural cell types in the septum. Our future work is focused on understanding the specific contribution of developmentally specified neural cell types in the regulation of internal states carried out by the septum.
URL:https://scienceinseattle.com/event/distinguished-seminar-series-corey-hartwell-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220914T103000
DTEND;TZID=America/Vancouver:20220914T113000
DTSTAMP:20260725T005049
CREATED:20220829T195831Z
LAST-MODIFIED:20220829T195831Z
UID:26894-1663151400-1663155000@scienceinseattle.com
SUMMARY:Distinguished Seminar Series - Corey Hartwell
DESCRIPTION:Development and neural diversity of septal nuclei \nSeptal nuclei in the basal forebrain have critical roles in regulating emotional states including fear\, anxiety\, and aggression. Dysfunction of septal neurons is thought to play a significant role in the pathophysiology of a variety of psychiatric disorders including schizophrenia\, bipolar disorder and depression. The septum can be classified into medial (MS)and lateral (LS) regions. The medial septum is composed of cholinergic\, GABAergic and glutamatergic neurons that primarily project to the hippocampus. The lateral septum is composed of a diverse array of GABAergic projection neurons that have reciprocal connections with numerous brain regions known to regulate emotional and motivational states. It is currently unclear how septal neuronal diversity and circuit wiring are specified during development. Using molecular genetics and single-cell/nuclei RNA-seq we have begun to unravel the developmental logic for producing diverse neural cell types in the septum. Our future work is focused on understanding the specific contribution of developmentally specified neural cell types in the regulation of internal states carried out by the septum.
URL:https://scienceinseattle.com/event/distinguished-seminar-series-corey-hartwell-3/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220914T180000
DTEND;TZID=UTC:20220914T190000
DTSTAMP:20260725T005049
CREATED:20220829T195541Z
LAST-MODIFIED:20220829T195541Z
UID:19268-1663178400-1663182000@scienceinseattle.com
SUMMARY:Meghan O’Rourke with Jim Heath
DESCRIPTION:A silent epidemic of chronic illnesses afflicts tens of millions of Americans: These are diseases that are poorly understood\, frequently marginalized\, and can go undiagnosed and unrecognized altogether. In her latest book – The Invisible Kingdom: Reimagining Chronic Illness – renowned writer Meghan O’Rourke delivers a revelatory investigation into this elusive category of “invisible” illness that encompasses autoimmune diseases\, post-treatment Lyme disease syndrome\, and now long COVID\, synthesizing the personal and the universal to help all of us through this new frontier. \nO’Rourke is joined by ISB President Dr. Jim Heath\, who has deeply studied long COVID and its similarities to other chronic illnesses\, to discuss chronic diseases\, how they’ve traditionally been understood and treated\, and what the future holds. \nMeghan O’Rourke is the author of the New York Times bestseller The Invisible Kingdom: Reimagining Chronic Illness and The Long Goodbye\, as well as the poetry collections Sun In Days\, Once\, and Halflife. Her writing has appeared in The Atlantic Monthly\, The New Yorker\, and The New York Times\, and more. The recipient of a Guggenheim Fellowship\, a Radcliffe Fellowship\, and a Whiting Nonfiction Award\, she resides in New Haven where she teaches at Yale University and is the editor of The Yale Review. \nDr. Jim Heath is President and Professor at Institute for Systems Biology in Seattle. Heath also has the position of Professor of Molecular and Medical Pharmacology at UCLA. Formerly\, he directed the National Cancer Institute-funded NSB Cancer Center\, was the Elizabeth W. Gilloon Professor of Chemistry at Caltech\, and served as co-director of the Parker Institute for Cancer Immunotherapy at UCLA until 2017.
URL:https://scienceinseattle.com/event/meghan-orourke-with-jim-heath/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220914T180000
DTEND;TZID=UTC:20220914T190000
DTSTAMP:20260725T005049
CREATED:20220829T195541Z
LAST-MODIFIED:20220829T195541Z
UID:25928-1663178400-1663182000@scienceinseattle.com
SUMMARY:Meghan O’Rourke with Jim Heath
DESCRIPTION:A silent epidemic of chronic illnesses afflicts tens of millions of Americans: These are diseases that are poorly understood\, frequently marginalized\, and can go undiagnosed and unrecognized altogether. In her latest book – The Invisible Kingdom: Reimagining Chronic Illness – renowned writer Meghan O’Rourke delivers a revelatory investigation into this elusive category of “invisible” illness that encompasses autoimmune diseases\, post-treatment Lyme disease syndrome\, and now long COVID\, synthesizing the personal and the universal to help all of us through this new frontier. \nO’Rourke is joined by ISB President Dr. Jim Heath\, who has deeply studied long COVID and its similarities to other chronic illnesses\, to discuss chronic diseases\, how they’ve traditionally been understood and treated\, and what the future holds. \nMeghan O’Rourke is the author of the New York Times bestseller The Invisible Kingdom: Reimagining Chronic Illness and The Long Goodbye\, as well as the poetry collections Sun In Days\, Once\, and Halflife. Her writing has appeared in The Atlantic Monthly\, The New Yorker\, and The New York Times\, and more. The recipient of a Guggenheim Fellowship\, a Radcliffe Fellowship\, and a Whiting Nonfiction Award\, she resides in New Haven where she teaches at Yale University and is the editor of The Yale Review. \nDr. Jim Heath is President and Professor at Institute for Systems Biology in Seattle. Heath also has the position of Professor of Molecular and Medical Pharmacology at UCLA. Formerly\, he directed the National Cancer Institute-funded NSB Cancer Center\, was the Elizabeth W. Gilloon Professor of Chemistry at Caltech\, and served as co-director of the Parker Institute for Cancer Immunotherapy at UCLA until 2017.
URL:https://scienceinseattle.com/event/meghan-orourke-with-jim-heath-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220914T180000
DTEND;TZID=UTC:20220914T190000
DTSTAMP:20260725T005049
CREATED:20220829T195541Z
LAST-MODIFIED:20220829T195541Z
UID:26892-1663178400-1663182000@scienceinseattle.com
SUMMARY:Meghan O’Rourke with Jim Heath
DESCRIPTION:A silent epidemic of chronic illnesses afflicts tens of millions of Americans: These are diseases that are poorly understood\, frequently marginalized\, and can go undiagnosed and unrecognized altogether. In her latest book – The Invisible Kingdom: Reimagining Chronic Illness – renowned writer Meghan O’Rourke delivers a revelatory investigation into this elusive category of “invisible” illness that encompasses autoimmune diseases\, post-treatment Lyme disease syndrome\, and now long COVID\, synthesizing the personal and the universal to help all of us through this new frontier. \nO’Rourke is joined by ISB President Dr. Jim Heath\, who has deeply studied long COVID and its similarities to other chronic illnesses\, to discuss chronic diseases\, how they’ve traditionally been understood and treated\, and what the future holds. \nMeghan O’Rourke is the author of the New York Times bestseller The Invisible Kingdom: Reimagining Chronic Illness and The Long Goodbye\, as well as the poetry collections Sun In Days\, Once\, and Halflife. Her writing has appeared in The Atlantic Monthly\, The New Yorker\, and The New York Times\, and more. The recipient of a Guggenheim Fellowship\, a Radcliffe Fellowship\, and a Whiting Nonfiction Award\, she resides in New Haven where she teaches at Yale University and is the editor of The Yale Review. \nDr. Jim Heath is President and Professor at Institute for Systems Biology in Seattle. Heath also has the position of Professor of Molecular and Medical Pharmacology at UCLA. Formerly\, he directed the National Cancer Institute-funded NSB Cancer Center\, was the Elizabeth W. Gilloon Professor of Chemistry at Caltech\, and served as co-director of the Parker Institute for Cancer Immunotherapy at UCLA until 2017.
URL:https://scienceinseattle.com/event/meghan-orourke-with-jim-heath-3/
LOCATION:Online
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