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DTSTART;TZID=America/Vancouver:20220503T090000
DTEND;TZID=America/Vancouver:20220503T100000
DTSTAMP:20260403T154040
CREATED:20220502T180844Z
LAST-MODIFIED:20220502T180844Z
UID:17772-1651568400-1651572000@scienceinseattle.com
SUMMARY:May Variant Effect Seminar Series
DESCRIPTION:Antonio Mollica Cohn lab\, University of Toronto \nPresentation Date: May 03\, 2022 \n“Identifying novel pathogenic mechanisms in brain development disorders” \nAntonio is a PhD candidate in Ronald Cohn’s laboratory at the Hospital for Sick Children in Toronto. He is interested in the challenges of gene discovery for rare genetic diseases. His work focuses on defining a novel role for variants causing complex brain development disorders. \nSocial: N/A
URL:https://scienceinseattle.com/event/may-variant-effect-seminar-series/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220503T090000
DTEND;TZID=America/Vancouver:20220503T100000
DTSTAMP:20260403T154040
CREATED:20220502T180844Z
LAST-MODIFIED:20220502T180844Z
UID:25891-1651568400-1651572000@scienceinseattle.com
SUMMARY:May Variant Effect Seminar Series
DESCRIPTION:Antonio Mollica Cohn lab\, University of Toronto \nPresentation Date: May 03\, 2022 \n“Identifying novel pathogenic mechanisms in brain development disorders” \nAntonio is a PhD candidate in Ronald Cohn’s laboratory at the Hospital for Sick Children in Toronto. He is interested in the challenges of gene discovery for rare genetic diseases. His work focuses on defining a novel role for variants causing complex brain development disorders. \nSocial: N/A
URL:https://scienceinseattle.com/event/may-variant-effect-seminar-series-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220503T090000
DTEND;TZID=America/Vancouver:20220503T100000
DTSTAMP:20260403T154040
CREATED:20220502T180844Z
LAST-MODIFIED:20220502T180844Z
UID:26856-1651568400-1651572000@scienceinseattle.com
SUMMARY:May Variant Effect Seminar Series
DESCRIPTION:Antonio Mollica Cohn lab\, University of Toronto \nPresentation Date: May 03\, 2022 \n“Identifying novel pathogenic mechanisms in brain development disorders” \nAntonio is a PhD candidate in Ronald Cohn’s laboratory at the Hospital for Sick Children in Toronto. He is interested in the challenges of gene discovery for rare genetic diseases. His work focuses on defining a novel role for variants causing complex brain development disorders. \nSocial: N/A
URL:https://scienceinseattle.com/event/may-variant-effect-seminar-series-3/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220504T120000
DTEND;TZID=America/Vancouver:20220504T130000
DTSTAMP:20260403T154040
CREATED:20220411T165417Z
LAST-MODIFIED:20220411T165417Z
UID:17417-1651665600-1651669200@scienceinseattle.com
SUMMARY:Cellular Therapy Series Part I: How Engineered Cellular Therapies are Reshaping Medicine
DESCRIPTION:Part 1: Wednesday\, May 4\, 2022\, 12:00 – 1:00 PM\nPart 2: Wednesday\, September 14\, 2022\, 12:00 – 1:00 PM \nCellular therapies are reshaping the therapeutic landscape\, representing one of the highest growth sectors for FDA IND applications\, spurring some of the most recognized young companies\, producing several high-value cancer drugs\, and transforming lives. The Seattle area has led the development from the start with seminal work by Dendreon\, bringing to market the first FDA-approved immunotherapy made from a patient’s own immune cells (Provenge)\, as well as pioneering advances in chimeric antigen receptor (CAR) T cell therapy by the Hutch\, Seattle Children’s Research Institute and Juno Therapeutics. Today the region remains at the forefront\, supporting the development and launch of two commercially available CAR T cell products\, Breyanzi (Juno/Celgene/Bristol Myers Squibb) and Abecma (2seventy bio (formerly bluebird bio)/Celgene/Bristol Myers Squibb)\, and delivering innovative cell therapies to put more patients on the path to a cure. Young cellular therapy companies with roots in Seattle such as\, Sana\, 2seventy bio\, Umoja\, GentiBio\, Notch Therapeutics\, Century Therapeutics\, Gilead\, Sonoma Bio\, Lyell\, among others promise to usher in the next era of innovation. The science is established. The patient benefits are real.  The possibilities are endless. \nPart 1 Focus:\n•  Where we are now—FDA Approved Therapies\n•  How we got here—the science in a broad international sense but specifically highlighting Seattle’s history in the development of cellular therapies.\n•  The history of how these therapies have made it to market. Special challenges this new technology had to face such as manufacturing.\n•  What therapies are currently on the market\n•  Special focus on how current therapies are putting more patients on a path to a cure \nPricing: \n$25 in-person (includes lunch and beverages)\n$10 virtual via zoom
URL:https://scienceinseattle.com/event/cellular-therapy-series-part-i-how-engineered-cellular-therapies-are-reshaping-medicine/
LOCATION:Online
ORGANIZER;CN="Life Science Washington":MAILTO:kaitlyn@lifesciencewa.org
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220504T120000
DTEND;TZID=America/Vancouver:20220504T130000
DTSTAMP:20260403T154040
CREATED:20220411T165417Z
LAST-MODIFIED:20220411T165417Z
UID:25875-1651665600-1651669200@scienceinseattle.com
SUMMARY:Cellular Therapy Series Part I: How Engineered Cellular Therapies are Reshaping Medicine
DESCRIPTION:Part 1: Wednesday\, May 4\, 2022\, 12:00 – 1:00 PM\nPart 2: Wednesday\, September 14\, 2022\, 12:00 – 1:00 PM \nCellular therapies are reshaping the therapeutic landscape\, representing one of the highest growth sectors for FDA IND applications\, spurring some of the most recognized young companies\, producing several high-value cancer drugs\, and transforming lives. The Seattle area has led the development from the start with seminal work by Dendreon\, bringing to market the first FDA-approved immunotherapy made from a patient’s own immune cells (Provenge)\, as well as pioneering advances in chimeric antigen receptor (CAR) T cell therapy by the Hutch\, Seattle Children’s Research Institute and Juno Therapeutics. Today the region remains at the forefront\, supporting the development and launch of two commercially available CAR T cell products\, Breyanzi (Juno/Celgene/Bristol Myers Squibb) and Abecma (2seventy bio (formerly bluebird bio)/Celgene/Bristol Myers Squibb)\, and delivering innovative cell therapies to put more patients on the path to a cure. Young cellular therapy companies with roots in Seattle such as\, Sana\, 2seventy bio\, Umoja\, GentiBio\, Notch Therapeutics\, Century Therapeutics\, Gilead\, Sonoma Bio\, Lyell\, among others promise to usher in the next era of innovation. The science is established. The patient benefits are real.  The possibilities are endless. \nPart 1 Focus:\n•  Where we are now—FDA Approved Therapies\n•  How we got here—the science in a broad international sense but specifically highlighting Seattle’s history in the development of cellular therapies.\n•  The history of how these therapies have made it to market. Special challenges this new technology had to face such as manufacturing.\n•  What therapies are currently on the market\n•  Special focus on how current therapies are putting more patients on a path to a cure \nPricing: \n$25 in-person (includes lunch and beverages)\n$10 virtual via zoom
URL:https://scienceinseattle.com/event/cellular-therapy-series-part-i-how-engineered-cellular-therapies-are-reshaping-medicine-2/
LOCATION:Online
ORGANIZER;CN="Life Science Washington":MAILTO:kaitlyn@lifesciencewa.org
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220504T120000
DTEND;TZID=America/Vancouver:20220504T130000
DTSTAMP:20260403T154040
CREATED:20220411T165417Z
LAST-MODIFIED:20220411T165417Z
UID:26840-1651665600-1651669200@scienceinseattle.com
SUMMARY:Cellular Therapy Series Part I: How Engineered Cellular Therapies are Reshaping Medicine
DESCRIPTION:Part 1: Wednesday\, May 4\, 2022\, 12:00 – 1:00 PM\nPart 2: Wednesday\, September 14\, 2022\, 12:00 – 1:00 PM \nCellular therapies are reshaping the therapeutic landscape\, representing one of the highest growth sectors for FDA IND applications\, spurring some of the most recognized young companies\, producing several high-value cancer drugs\, and transforming lives. The Seattle area has led the development from the start with seminal work by Dendreon\, bringing to market the first FDA-approved immunotherapy made from a patient’s own immune cells (Provenge)\, as well as pioneering advances in chimeric antigen receptor (CAR) T cell therapy by the Hutch\, Seattle Children’s Research Institute and Juno Therapeutics. Today the region remains at the forefront\, supporting the development and launch of two commercially available CAR T cell products\, Breyanzi (Juno/Celgene/Bristol Myers Squibb) and Abecma (2seventy bio (formerly bluebird bio)/Celgene/Bristol Myers Squibb)\, and delivering innovative cell therapies to put more patients on the path to a cure. Young cellular therapy companies with roots in Seattle such as\, Sana\, 2seventy bio\, Umoja\, GentiBio\, Notch Therapeutics\, Century Therapeutics\, Gilead\, Sonoma Bio\, Lyell\, among others promise to usher in the next era of innovation. The science is established. The patient benefits are real.  The possibilities are endless. \nPart 1 Focus:\n•  Where we are now—FDA Approved Therapies\n•  How we got here—the science in a broad international sense but specifically highlighting Seattle’s history in the development of cellular therapies.\n•  The history of how these therapies have made it to market. Special challenges this new technology had to face such as manufacturing.\n•  What therapies are currently on the market\n•  Special focus on how current therapies are putting more patients on a path to a cure \nPricing: \n$25 in-person (includes lunch and beverages)\n$10 virtual via zoom
URL:https://scienceinseattle.com/event/cellular-therapy-series-part-i-how-engineered-cellular-therapies-are-reshaping-medicine-3/
LOCATION:Online
ORGANIZER;CN="Life Science Washington":MAILTO:kaitlyn@lifesciencewa.org
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220504T120000
DTEND;TZID=UTC:20220504T130000
DTSTAMP:20260403T154040
CREATED:20220502T180628Z
LAST-MODIFIED:20220502T180628Z
UID:17766-1651665600-1651669200@scienceinseattle.com
SUMMARY:Biostatistics Seminar Series
DESCRIPTION:The Fred Hutch Biostatistics Program hosts seminars featuring presentations by Fred Hutch and outside scientists to share their latest developments and recent research. Each seminar includes an hour-long presentation and discussion during which speakers showcase their work and findings. \nThis seminar will be held on Zoom due to the COVID-19 pandemic. \nPRESENTER: Andy Ni\, Ph.D.\n\n“Contrast Weighted Learning for Robust Optimal Treatment Regimen Estimation”\n\n\nPersonalized medicine aims to tailor medical decisions based on patient-specific characteristics. Advances in data capturing techniques such as electronic health records dramatically increase the availability of comprehensive patient profiles\, promoting the rapid development of optimal treatment rule (OTR) estimation methods. An archetypal OTR estimation approach is the outcome weighted learning\, where OTR is determined under a weighted classification framework with clinical outcomes as the weights. Although outcome weighted learning has been extensively studied and extended\, existing methods are susceptible to irregularities of outcome distributions such as outliers and heavy tails.  Methods that involve modeling of the outcome are also sensitive to model misspecification. We propose a contrast weighted learning (CWL) framework that exploits the flexibility and robustness of contrast functions to enable robust OTR estimation for a wide range of clinical outcomes. The novel value function in CWL only depends on the pairwise contrast of clinical outcomes between patients irrespective of their distributional features and supports. The Fisher consistency and convergence rate of the estimated decision rule via CWL are established. We illustrate the superiority of the proposed method under finite samples using comprehensive simulation studies with ill-distributed continuous outcomes and ordinal outcomes. We apply the CWL method to two datasets from clinical trials on idiopathic pulmonary fibrosis and COVID-19 to demonstrate its real-world application.
URL:https://scienceinseattle.com/event/biostatistics-seminar-series-9/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220504T120000
DTEND;TZID=UTC:20220504T130000
DTSTAMP:20260403T154040
CREATED:20220502T180628Z
LAST-MODIFIED:20220502T180628Z
UID:25889-1651665600-1651669200@scienceinseattle.com
SUMMARY:Biostatistics Seminar Series
DESCRIPTION:The Fred Hutch Biostatistics Program hosts seminars featuring presentations by Fred Hutch and outside scientists to share their latest developments and recent research. Each seminar includes an hour-long presentation and discussion during which speakers showcase their work and findings. \nThis seminar will be held on Zoom due to the COVID-19 pandemic. \nPRESENTER: Andy Ni\, Ph.D.\n\n“Contrast Weighted Learning for Robust Optimal Treatment Regimen Estimation”\n\n\nPersonalized medicine aims to tailor medical decisions based on patient-specific characteristics. Advances in data capturing techniques such as electronic health records dramatically increase the availability of comprehensive patient profiles\, promoting the rapid development of optimal treatment rule (OTR) estimation methods. An archetypal OTR estimation approach is the outcome weighted learning\, where OTR is determined under a weighted classification framework with clinical outcomes as the weights. Although outcome weighted learning has been extensively studied and extended\, existing methods are susceptible to irregularities of outcome distributions such as outliers and heavy tails.  Methods that involve modeling of the outcome are also sensitive to model misspecification. We propose a contrast weighted learning (CWL) framework that exploits the flexibility and robustness of contrast functions to enable robust OTR estimation for a wide range of clinical outcomes. The novel value function in CWL only depends on the pairwise contrast of clinical outcomes between patients irrespective of their distributional features and supports. The Fisher consistency and convergence rate of the estimated decision rule via CWL are established. We illustrate the superiority of the proposed method under finite samples using comprehensive simulation studies with ill-distributed continuous outcomes and ordinal outcomes. We apply the CWL method to two datasets from clinical trials on idiopathic pulmonary fibrosis and COVID-19 to demonstrate its real-world application.
URL:https://scienceinseattle.com/event/biostatistics-seminar-series-9-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220504T120000
DTEND;TZID=UTC:20220504T130000
DTSTAMP:20260403T154040
CREATED:20220502T180628Z
LAST-MODIFIED:20220502T180628Z
UID:26854-1651665600-1651669200@scienceinseattle.com
SUMMARY:Biostatistics Seminar Series
DESCRIPTION:The Fred Hutch Biostatistics Program hosts seminars featuring presentations by Fred Hutch and outside scientists to share their latest developments and recent research. Each seminar includes an hour-long presentation and discussion during which speakers showcase their work and findings. \nThis seminar will be held on Zoom due to the COVID-19 pandemic. \nPRESENTER: Andy Ni\, Ph.D.\n\n“Contrast Weighted Learning for Robust Optimal Treatment Regimen Estimation”\n\n\nPersonalized medicine aims to tailor medical decisions based on patient-specific characteristics. Advances in data capturing techniques such as electronic health records dramatically increase the availability of comprehensive patient profiles\, promoting the rapid development of optimal treatment rule (OTR) estimation methods. An archetypal OTR estimation approach is the outcome weighted learning\, where OTR is determined under a weighted classification framework with clinical outcomes as the weights. Although outcome weighted learning has been extensively studied and extended\, existing methods are susceptible to irregularities of outcome distributions such as outliers and heavy tails.  Methods that involve modeling of the outcome are also sensitive to model misspecification. We propose a contrast weighted learning (CWL) framework that exploits the flexibility and robustness of contrast functions to enable robust OTR estimation for a wide range of clinical outcomes. The novel value function in CWL only depends on the pairwise contrast of clinical outcomes between patients irrespective of their distributional features and supports. The Fisher consistency and convergence rate of the estimated decision rule via CWL are established. We illustrate the superiority of the proposed method under finite samples using comprehensive simulation studies with ill-distributed continuous outcomes and ordinal outcomes. We apply the CWL method to two datasets from clinical trials on idiopathic pulmonary fibrosis and COVID-19 to demonstrate its real-world application.
URL:https://scienceinseattle.com/event/biostatistics-seminar-series-9-3/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20220505
DTEND;VALUE=DATE:20220507
DTSTAMP:20260403T154040
CREATED:20220502T174131Z
LAST-MODIFIED:20220502T174131Z
UID:17725-1651708800-1651881599@scienceinseattle.com
SUMMARY:Art Auction benefiting Seattle Children's Hospital
DESCRIPTION:The Box House is holding an art auction benefiting Seattle Children’s for two days. There will be silent auction items as well as a live auction. Each artist can choose how much of the sale price goes to SCH. The minimum allowed to be donated is is 20%. Art coming in ranges from $50 to $3000 and up.
URL:https://scienceinseattle.com/event/art-auction-benefiting-seattle-childrens-hospital/
LOCATION:Box House/Underground\, 124 South Washington Street\, Seattle\, WA\, 98104\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20220505
DTEND;VALUE=DATE:20220507
DTSTAMP:20260403T154040
CREATED:20220502T174131Z
LAST-MODIFIED:20220502T174131Z
UID:25877-1651708800-1651881599@scienceinseattle.com
SUMMARY:Art Auction benefiting Seattle Children's Hospital
DESCRIPTION:The Box House is holding an art auction benefiting Seattle Children’s for two days. There will be silent auction items as well as a live auction. Each artist can choose how much of the sale price goes to SCH. The minimum allowed to be donated is is 20%. Art coming in ranges from $50 to $3000 and up.
URL:https://scienceinseattle.com/event/art-auction-benefiting-seattle-childrens-hospital-2/
LOCATION:Box House/Underground\, 124 South Washington Street\, Seattle\, WA\, 98104\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20220505
DTEND;VALUE=DATE:20220507
DTSTAMP:20260403T154040
CREATED:20220502T174131Z
LAST-MODIFIED:20220502T174131Z
UID:26842-1651708800-1651881599@scienceinseattle.com
SUMMARY:Art Auction benefiting Seattle Children's Hospital
DESCRIPTION:The Box House is holding an art auction benefiting Seattle Children’s for two days. There will be silent auction items as well as a live auction. Each artist can choose how much of the sale price goes to SCH. The minimum allowed to be donated is is 20%. Art coming in ranges from $50 to $3000 and up.
URL:https://scienceinseattle.com/event/art-auction-benefiting-seattle-childrens-hospital-3/
LOCATION:Box House/Underground\, 124 South Washington Street\, Seattle\, WA\, 98104\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220507T160000
DTEND;TZID=America/Vancouver:20220507T170000
DTSTAMP:20260403T154040
CREATED:20220502T174231Z
LAST-MODIFIED:20220502T174231Z
UID:17729-1651939200-1651942800@scienceinseattle.com
SUMMARY:Research Roundtable with Chris Lausted and Dr. Danielle Vermaak
DESCRIPTION:DNA Sequencing in the High School Classroom\nJune 7\, 2022 at 4:00 PM PT. Register to receive access to this online event.  \n\nISB’s Research Roundtable is a virtual series that is free and open to all. These events are designed for a lay audience and provide opportunities to ask questions directly to our scientists. \nCheck out our Events Page for more upcoming events. \nA link to the event will be emailed to you upon registration. If you have additional questions\, please email Audri Hubbard at ahubbard@isbscience.org.
URL:https://scienceinseattle.com/event/research-roundtable-with-chris-lausted-and-dr-danielle-vermaak/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220507T160000
DTEND;TZID=America/Vancouver:20220507T170000
DTSTAMP:20260403T154040
CREATED:20220502T174231Z
LAST-MODIFIED:20220502T174231Z
UID:25878-1651939200-1651942800@scienceinseattle.com
SUMMARY:Research Roundtable with Chris Lausted and Dr. Danielle Vermaak
DESCRIPTION:DNA Sequencing in the High School Classroom\nJune 7\, 2022 at 4:00 PM PT. Register to receive access to this online event.  \n\nISB’s Research Roundtable is a virtual series that is free and open to all. These events are designed for a lay audience and provide opportunities to ask questions directly to our scientists. \nCheck out our Events Page for more upcoming events. \nA link to the event will be emailed to you upon registration. If you have additional questions\, please email Audri Hubbard at ahubbard@isbscience.org.
URL:https://scienceinseattle.com/event/research-roundtable-with-chris-lausted-and-dr-danielle-vermaak-3/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220507T160000
DTEND;TZID=America/Vancouver:20220507T170000
DTSTAMP:20260403T154040
CREATED:20220502T174231Z
LAST-MODIFIED:20220502T174231Z
UID:26843-1651939200-1651942800@scienceinseattle.com
SUMMARY:Research Roundtable with Chris Lausted and Dr. Danielle Vermaak
DESCRIPTION:DNA Sequencing in the High School Classroom\nJune 7\, 2022 at 4:00 PM PT. Register to receive access to this online event.  \n\nISB’s Research Roundtable is a virtual series that is free and open to all. These events are designed for a lay audience and provide opportunities to ask questions directly to our scientists. \nCheck out our Events Page for more upcoming events. \nA link to the event will be emailed to you upon registration. If you have additional questions\, please email Audri Hubbard at ahubbard@isbscience.org.
URL:https://scienceinseattle.com/event/research-roundtable-with-chris-lausted-and-dr-danielle-vermaak-4/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220507T180000
DTEND;TZID=UTC:20220507T230000
DTSTAMP:20260403T154040
CREATED:20220328T193611Z
LAST-MODIFIED:20220328T193611Z
UID:17240-1651946400-1651964400@scienceinseattle.com
SUMMARY:Desert Sun Guild's Spring Gala
DESCRIPTION:Dinner\, Auction and Dancing. Entertainment by Groove Principal.
URL:https://scienceinseattle.com/event/desert-sun-guilds-spring-gala/
LOCATION:Michele’s Event Center\, 2323 Henderson Loop\, Richland\, WA\, 99354\, United States
ATTACH;FMTTYPE=image/jpeg:https://scienceinseattle.com/wp-content/uploads/sites/4/2022/03/DgAB1hCbHuLnqa4zm92xTZmV.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220507T180000
DTEND;TZID=UTC:20220507T230000
DTSTAMP:20260403T154040
CREATED:20220328T193611Z
LAST-MODIFIED:20220328T193611Z
UID:25871-1651946400-1651964400@scienceinseattle.com
SUMMARY:Desert Sun Guild's Spring Gala
DESCRIPTION:Dinner\, Auction and Dancing. Entertainment by Groove Principal.
URL:https://scienceinseattle.com/event/desert-sun-guilds-spring-gala-2/
LOCATION:Michele’s Event Center\, 2323 Henderson Loop\, Richland\, WA\, 99354\, United States
ATTACH;FMTTYPE=image/jpeg:https://scienceinseattle.com/wp-content/uploads/sites/4/2022/03/DgAB1hCbHuLnqa4zm92xTZmV.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220507T180000
DTEND;TZID=UTC:20220507T230000
DTSTAMP:20260403T154040
CREATED:20220328T193611Z
LAST-MODIFIED:20220328T193611Z
UID:26836-1651946400-1651964400@scienceinseattle.com
SUMMARY:Desert Sun Guild's Spring Gala
DESCRIPTION:Dinner\, Auction and Dancing. Entertainment by Groove Principal.
URL:https://scienceinseattle.com/event/desert-sun-guilds-spring-gala-3/
LOCATION:Michele’s Event Center\, 2323 Henderson Loop\, Richland\, WA\, 99354\, United States
ATTACH;FMTTYPE=image/jpeg:https://scienceinseattle.com/wp-content/uploads/sites/4/2022/03/DgAB1hCbHuLnqa4zm92xTZmV.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220510T103000
DTEND;TZID=UTC:20220510T113000
DTSTAMP:20260403T154040
CREATED:20220328T192919Z
LAST-MODIFIED:20220509T164123Z
UID:17231-1652178600-1652182200@scienceinseattle.com
SUMMARY:Distinguished Seminar: Ilana Witten
DESCRIPTION:Ilana Witten is a professor of neuroscience and psychology at Princeton University. She was first introduced to neuroscience as an undergraduate physics major\, when she studied neural coding in the retina with Michael Berry at Princeton. She then moved to Stanford to pursue a PhD in neuroscience\, where she worked in the systems neuroscience lab of Eric Knudsen. As a postdoctoral fellow\, she worked with Karl Deisseroth in the Department of Bioengineering at Stanford\, developing and applying optogenetic tools to dissect the neuromodulatory control of reward behavior in rodents. Since 2012\, her lab at the Neuroscience Institute and Department of Psychology at Princeton has focused on understanding the circuitry in the striatum that support reward learning and decision making. She has received multiple awards for her work\, including an NIH New Innovator Award\, a Mcknight Scholars Award\, and the Daniel X Freedman Prize.
URL:https://scienceinseattle.com/event/distinguished-seminar-ilana-witten/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220510T103000
DTEND;TZID=UTC:20220510T113000
DTSTAMP:20260403T154040
CREATED:20220328T192919Z
LAST-MODIFIED:20220328T192919Z
UID:25868-1652178600-1652182200@scienceinseattle.com
SUMMARY:Distinguished Seminar: Ilana Witten
DESCRIPTION:Ilana Witten is a professor of neuroscience and psychology at Princeton University. She was first introduced to neuroscience as an undergraduate physics major\, when she studied neural coding in the retina with Michael Berry at Princeton. She then moved to Stanford to pursue a PhD in neuroscience\, where she worked in the systems neuroscience lab of Eric Knudsen. As a postdoctoral fellow\, she worked with Karl Deisseroth in the Department of Bioengineering at Stanford\, developing and applying optogenetic tools to dissect the neuromodulatory control of reward behavior in rodents. Since 2012\, her lab at the Neuroscience Institute and Department of Psychology at Princeton has focused on understanding the circuitry in the striatum that support reward learning and decision making. She has received multiple awards for her work\, including an NIH New Innovator Award\, a Mcknight Scholars Award\, and the Daniel X Freedman Prize.
URL:https://scienceinseattle.com/event/distinguished-seminar-ilana-witten-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220510T103000
DTEND;TZID=UTC:20220510T113000
DTSTAMP:20260403T154040
CREATED:20220328T192919Z
LAST-MODIFIED:20220328T192919Z
UID:26833-1652178600-1652182200@scienceinseattle.com
SUMMARY:Distinguished Seminar: Ilana Witten
DESCRIPTION:Ilana Witten is a professor of neuroscience and psychology at Princeton University. She was first introduced to neuroscience as an undergraduate physics major\, when she studied neural coding in the retina with Michael Berry at Princeton. She then moved to Stanford to pursue a PhD in neuroscience\, where she worked in the systems neuroscience lab of Eric Knudsen. As a postdoctoral fellow\, she worked with Karl Deisseroth in the Department of Bioengineering at Stanford\, developing and applying optogenetic tools to dissect the neuromodulatory control of reward behavior in rodents. Since 2012\, her lab at the Neuroscience Institute and Department of Psychology at Princeton has focused on understanding the circuitry in the striatum that support reward learning and decision making. She has received multiple awards for her work\, including an NIH New Innovator Award\, a Mcknight Scholars Award\, and the Daniel X Freedman Prize.
URL:https://scienceinseattle.com/event/distinguished-seminar-ilana-witten-3/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220510T160000
DTEND;TZID=America/Vancouver:20220510T173000
DTSTAMP:20260403T154040
CREATED:20220502T181831Z
LAST-MODIFIED:20220502T181831Z
UID:17792-1652198400-1652203800@scienceinseattle.com
SUMMARY:DeviceConnect: Novel Delivery Mechanisms for Modern Medicine
DESCRIPTION:The rapid evolution of modern medicine has spurred incredible advancements in vaccine and drug delivery. As the pace of innovation and drug discovery continues to accelerate\, medical device R&D organizations have had to keep pace to effectively produce mechanisms to deliver these critical and emerging treatments. In this DeviceConnect\, we’ll hear directly from leaders who are innovating on the medical and delivery sides to meet modern needs and patient scenarios.
URL:https://scienceinseattle.com/event/deviceconnect-novel-delivery-mechanisms-for-modern-medicine/
LOCATION:Online
ORGANIZER;CN="Life Science Washington":MAILTO:kaitlyn@lifesciencewa.org
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220510T160000
DTEND;TZID=America/Vancouver:20220510T173000
DTSTAMP:20260403T154040
CREATED:20220502T181831Z
LAST-MODIFIED:20220502T181831Z
UID:25897-1652198400-1652203800@scienceinseattle.com
SUMMARY:DeviceConnect: Novel Delivery Mechanisms for Modern Medicine
DESCRIPTION:The rapid evolution of modern medicine has spurred incredible advancements in vaccine and drug delivery. As the pace of innovation and drug discovery continues to accelerate\, medical device R&D organizations have had to keep pace to effectively produce mechanisms to deliver these critical and emerging treatments. In this DeviceConnect\, we’ll hear directly from leaders who are innovating on the medical and delivery sides to meet modern needs and patient scenarios.
URL:https://scienceinseattle.com/event/deviceconnect-novel-delivery-mechanisms-for-modern-medicine-2/
LOCATION:Online
ORGANIZER;CN="Life Science Washington":MAILTO:kaitlyn@lifesciencewa.org
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220510T160000
DTEND;TZID=America/Vancouver:20220510T173000
DTSTAMP:20260403T154040
CREATED:20220502T181831Z
LAST-MODIFIED:20220502T181831Z
UID:26862-1652198400-1652203800@scienceinseattle.com
SUMMARY:DeviceConnect: Novel Delivery Mechanisms for Modern Medicine
DESCRIPTION:The rapid evolution of modern medicine has spurred incredible advancements in vaccine and drug delivery. As the pace of innovation and drug discovery continues to accelerate\, medical device R&D organizations have had to keep pace to effectively produce mechanisms to deliver these critical and emerging treatments. In this DeviceConnect\, we’ll hear directly from leaders who are innovating on the medical and delivery sides to meet modern needs and patient scenarios.
URL:https://scienceinseattle.com/event/deviceconnect-novel-delivery-mechanisms-for-modern-medicine-3/
LOCATION:Online
ORGANIZER;CN="Life Science Washington":MAILTO:kaitlyn@lifesciencewa.org
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220511T120000
DTEND;TZID=America/Vancouver:20220511T130000
DTSTAMP:20260403T154040
CREATED:20220502T180538Z
LAST-MODIFIED:20220502T180538Z
UID:17763-1652270400-1652274000@scienceinseattle.com
SUMMARY:Biostatistics Seminar Series
DESCRIPTION:The Fred Hutch Biostatistics Program hosts seminars featuring presentations by Fred Hutch and outside scientists to share their latest developments and recent research. Each seminar includes an hour-long presentation and discussion during which speakers showcase their work and findings. \nThis seminar will be held on Zoom due to the COVID-19 pandemic. \nPRESENTER: Min Qian\, Ph.D.\n\n“Regularized greedy gradient Q-learning with mobile health applications”\n\n\nRecent advance in health and technology has made mobile apps a viable approach to delivering behavioral interventions in areas including physical activity encouragement\, smoking cessation\, substance abuse prevention\, and mental health management. Due to the chronic nature of most of the disorders and heterogeneity among mobile users\, delivery of the interventions needs to be sequential and tailored to individual needs. We operationalize the sequential decision making via a policy that takes a mobile user’s past usage pattern and health status as input and outputs an app/intervention recommendation with the goal of optimizing the cumulative rewards of interest in an indefinite horizon setting. we propose a regularized greedy gradient Q-learning (RGGQ) method to tackle this estimation problem. The optimal policy is estimated via an algorithm that synthesizes the PGM and the GGQ algorithms\, and its asymptotic properties are established.
URL:https://scienceinseattle.com/event/biostatistics-seminar-series-8/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220511T120000
DTEND;TZID=America/Vancouver:20220511T130000
DTSTAMP:20260403T154040
CREATED:20220502T180538Z
LAST-MODIFIED:20220502T180538Z
UID:25888-1652270400-1652274000@scienceinseattle.com
SUMMARY:Biostatistics Seminar Series
DESCRIPTION:The Fred Hutch Biostatistics Program hosts seminars featuring presentations by Fred Hutch and outside scientists to share their latest developments and recent research. Each seminar includes an hour-long presentation and discussion during which speakers showcase their work and findings. \nThis seminar will be held on Zoom due to the COVID-19 pandemic. \nPRESENTER: Min Qian\, Ph.D.\n\n“Regularized greedy gradient Q-learning with mobile health applications”\n\n\nRecent advance in health and technology has made mobile apps a viable approach to delivering behavioral interventions in areas including physical activity encouragement\, smoking cessation\, substance abuse prevention\, and mental health management. Due to the chronic nature of most of the disorders and heterogeneity among mobile users\, delivery of the interventions needs to be sequential and tailored to individual needs. We operationalize the sequential decision making via a policy that takes a mobile user’s past usage pattern and health status as input and outputs an app/intervention recommendation with the goal of optimizing the cumulative rewards of interest in an indefinite horizon setting. we propose a regularized greedy gradient Q-learning (RGGQ) method to tackle this estimation problem. The optimal policy is estimated via an algorithm that synthesizes the PGM and the GGQ algorithms\, and its asymptotic properties are established.
URL:https://scienceinseattle.com/event/biostatistics-seminar-series-8-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220511T120000
DTEND;TZID=America/Vancouver:20220511T130000
DTSTAMP:20260403T154040
CREATED:20220502T180538Z
LAST-MODIFIED:20220502T180538Z
UID:26853-1652270400-1652274000@scienceinseattle.com
SUMMARY:Biostatistics Seminar Series
DESCRIPTION:The Fred Hutch Biostatistics Program hosts seminars featuring presentations by Fred Hutch and outside scientists to share their latest developments and recent research. Each seminar includes an hour-long presentation and discussion during which speakers showcase their work and findings. \nThis seminar will be held on Zoom due to the COVID-19 pandemic. \nPRESENTER: Min Qian\, Ph.D.\n\n“Regularized greedy gradient Q-learning with mobile health applications”\n\n\nRecent advance in health and technology has made mobile apps a viable approach to delivering behavioral interventions in areas including physical activity encouragement\, smoking cessation\, substance abuse prevention\, and mental health management. Due to the chronic nature of most of the disorders and heterogeneity among mobile users\, delivery of the interventions needs to be sequential and tailored to individual needs. We operationalize the sequential decision making via a policy that takes a mobile user’s past usage pattern and health status as input and outputs an app/intervention recommendation with the goal of optimizing the cumulative rewards of interest in an indefinite horizon setting. we propose a regularized greedy gradient Q-learning (RGGQ) method to tackle this estimation problem. The optimal policy is estimated via an algorithm that synthesizes the PGM and the GGQ algorithms\, and its asymptotic properties are established.
URL:https://scienceinseattle.com/event/biostatistics-seminar-series-8-3/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220512T080000
DTEND;TZID=America/Vancouver:20220512T140000
DTSTAMP:20260403T154040
CREATED:20220502T175912Z
LAST-MODIFIED:20220502T175912Z
UID:17743-1652342400-1652364000@scienceinseattle.com
SUMMARY:Frameworks for Brain Cell Type Definition\, Ontology\, and Nomenclature Workshop: Mapping of Cell Type Data
DESCRIPTION:In this virtual workshop\, we will explore best practices for mapping single cell data to reference cell atlases. Mapping single cell data to reference cell atlases is complicated by batch effects between datasets\, systematic differences in biological conditions of the samples\, limited availability of computational resources\, and sharing restrictions on raw data. While our focus is on transcriptomically-defined cell types of the brain\, applications in other tissues and in the use of other data modalities will also be considered. \n\n\n\n\n\n\nThursday\, May 12\, 2022\n8am-2pm Pacific Time \nREGISTRATION: GENERAL ATTENDEE \nGeneral attendees are invited to listen to the full workshop and pose questions to the speakers. Registration is free. \nREGISTRATION: DATA CHALLENGE \nData challenge participants will submit preliminary results and have the opportunity to present at the workshop. Participation is free. \n\n\n\n\n\n\n\n\n\nDefining and naming cell types is a key problem of contemporary neuroscience. While the problem has preoccupied neuroscientists for over a century\, it now has significantly increased attention due to our ability to collect cellular level data in a high-throughput manner. International consortia involved in molecular brain cell classification\, including the BRAIN Initiative Cell Census Network (BICCN)\, the Human Cell Atlas (HCA)\, and the Human Biomolecular Atlas Program (HuBMAP) are generating and classifying cell types in all organ systems in the human body at a rapid pace. Standards for classification\, naming\, and data mapping are essential to form a common language of cell types to make sense of these enormous datasets\, and to promote understanding between multiple domains\, projects\, and scientists. \nEssential to our understanding of cell types and their functions is to catalog measured transcriptomes of cells belonging to each cell type\, and to present this information in the form of comprehensive reference single cell atlases. Much like how reference genomes provide a map for locating the origin of sequencing reads\, reference cell atlases can be used to map query cells to potential cell types in the reference atlas in order to rapidly characterize and compare relevant cell phenotypes. Reference atlases ultimately help quantify transcriptional heterogeneity that arises as a result of natural variation\, aging\, environmental influences\, and disease. Large single-cell atlases comprising millions of cells across tissues\, organs\, donors\, developmental stages\, and conditions are now being generated by consortia such as the Human Cell Atlas and BICCN to serve as references for smaller-scale studies. \nThe workshop will include presentations about key state-of-the-art methods and techniques\, and a comparison of results obtained by different methods in a hands-on data mapping challenge. To explore these mapping techniques\, workshop participants will be provided with data mapping “challenges” to be completed before the workshop. Creative solutions to these challenges will have the opportunity to present to a national audience at the June 6\, 2022\, BRAIN Initiative Cell Census Network (BICCN) consortium meeting and participate in a published article detailing the challenge results.
URL:https://scienceinseattle.com/event/frameworks-for-brain-cell-type-definition-ontology-and-nomenclature-workshop-mapping-of-cell-type-data/
LOCATION:Online
ATTACH;FMTTYPE=image/png:https://scienceinseattle.com/wp-content/uploads/sites/4/2022/05/mappingdatabanner.png__800x800_q75_subsampling-2.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220512T080000
DTEND;TZID=America/Vancouver:20220512T140000
DTSTAMP:20260403T154040
CREATED:20220502T175912Z
LAST-MODIFIED:20220502T175912Z
UID:25882-1652342400-1652364000@scienceinseattle.com
SUMMARY:Frameworks for Brain Cell Type Definition\, Ontology\, and Nomenclature Workshop: Mapping of Cell Type Data
DESCRIPTION:In this virtual workshop\, we will explore best practices for mapping single cell data to reference cell atlases. Mapping single cell data to reference cell atlases is complicated by batch effects between datasets\, systematic differences in biological conditions of the samples\, limited availability of computational resources\, and sharing restrictions on raw data. While our focus is on transcriptomically-defined cell types of the brain\, applications in other tissues and in the use of other data modalities will also be considered. \n\n\n\n\n\n\nThursday\, May 12\, 2022\n8am-2pm Pacific Time \nREGISTRATION: GENERAL ATTENDEE \nGeneral attendees are invited to listen to the full workshop and pose questions to the speakers. Registration is free. \nREGISTRATION: DATA CHALLENGE \nData challenge participants will submit preliminary results and have the opportunity to present at the workshop. Participation is free. \n\n\n\n\n\n\n\n\n\nDefining and naming cell types is a key problem of contemporary neuroscience. While the problem has preoccupied neuroscientists for over a century\, it now has significantly increased attention due to our ability to collect cellular level data in a high-throughput manner. International consortia involved in molecular brain cell classification\, including the BRAIN Initiative Cell Census Network (BICCN)\, the Human Cell Atlas (HCA)\, and the Human Biomolecular Atlas Program (HuBMAP) are generating and classifying cell types in all organ systems in the human body at a rapid pace. Standards for classification\, naming\, and data mapping are essential to form a common language of cell types to make sense of these enormous datasets\, and to promote understanding between multiple domains\, projects\, and scientists. \nEssential to our understanding of cell types and their functions is to catalog measured transcriptomes of cells belonging to each cell type\, and to present this information in the form of comprehensive reference single cell atlases. Much like how reference genomes provide a map for locating the origin of sequencing reads\, reference cell atlases can be used to map query cells to potential cell types in the reference atlas in order to rapidly characterize and compare relevant cell phenotypes. Reference atlases ultimately help quantify transcriptional heterogeneity that arises as a result of natural variation\, aging\, environmental influences\, and disease. Large single-cell atlases comprising millions of cells across tissues\, organs\, donors\, developmental stages\, and conditions are now being generated by consortia such as the Human Cell Atlas and BICCN to serve as references for smaller-scale studies. \nThe workshop will include presentations about key state-of-the-art methods and techniques\, and a comparison of results obtained by different methods in a hands-on data mapping challenge. To explore these mapping techniques\, workshop participants will be provided with data mapping “challenges” to be completed before the workshop. Creative solutions to these challenges will have the opportunity to present to a national audience at the June 6\, 2022\, BRAIN Initiative Cell Census Network (BICCN) consortium meeting and participate in a published article detailing the challenge results.
URL:https://scienceinseattle.com/event/frameworks-for-brain-cell-type-definition-ontology-and-nomenclature-workshop-mapping-of-cell-type-data-2/
LOCATION:Online
ATTACH;FMTTYPE=image/png:https://scienceinseattle.com/wp-content/uploads/sites/4/2022/05/mappingdatabanner.png__800x800_q75_subsampling-2.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220512T080000
DTEND;TZID=America/Vancouver:20220512T140000
DTSTAMP:20260403T154040
CREATED:20220502T175912Z
LAST-MODIFIED:20220502T175912Z
UID:26847-1652342400-1652364000@scienceinseattle.com
SUMMARY:Frameworks for Brain Cell Type Definition\, Ontology\, and Nomenclature Workshop: Mapping of Cell Type Data
DESCRIPTION:In this virtual workshop\, we will explore best practices for mapping single cell data to reference cell atlases. Mapping single cell data to reference cell atlases is complicated by batch effects between datasets\, systematic differences in biological conditions of the samples\, limited availability of computational resources\, and sharing restrictions on raw data. While our focus is on transcriptomically-defined cell types of the brain\, applications in other tissues and in the use of other data modalities will also be considered. \n\n\n\n\n\n\nThursday\, May 12\, 2022\n8am-2pm Pacific Time \nREGISTRATION: GENERAL ATTENDEE \nGeneral attendees are invited to listen to the full workshop and pose questions to the speakers. Registration is free. \nREGISTRATION: DATA CHALLENGE \nData challenge participants will submit preliminary results and have the opportunity to present at the workshop. Participation is free. \n\n\n\n\n\n\n\n\n\nDefining and naming cell types is a key problem of contemporary neuroscience. While the problem has preoccupied neuroscientists for over a century\, it now has significantly increased attention due to our ability to collect cellular level data in a high-throughput manner. International consortia involved in molecular brain cell classification\, including the BRAIN Initiative Cell Census Network (BICCN)\, the Human Cell Atlas (HCA)\, and the Human Biomolecular Atlas Program (HuBMAP) are generating and classifying cell types in all organ systems in the human body at a rapid pace. Standards for classification\, naming\, and data mapping are essential to form a common language of cell types to make sense of these enormous datasets\, and to promote understanding between multiple domains\, projects\, and scientists. \nEssential to our understanding of cell types and their functions is to catalog measured transcriptomes of cells belonging to each cell type\, and to present this information in the form of comprehensive reference single cell atlases. Much like how reference genomes provide a map for locating the origin of sequencing reads\, reference cell atlases can be used to map query cells to potential cell types in the reference atlas in order to rapidly characterize and compare relevant cell phenotypes. Reference atlases ultimately help quantify transcriptional heterogeneity that arises as a result of natural variation\, aging\, environmental influences\, and disease. Large single-cell atlases comprising millions of cells across tissues\, organs\, donors\, developmental stages\, and conditions are now being generated by consortia such as the Human Cell Atlas and BICCN to serve as references for smaller-scale studies. \nThe workshop will include presentations about key state-of-the-art methods and techniques\, and a comparison of results obtained by different methods in a hands-on data mapping challenge. To explore these mapping techniques\, workshop participants will be provided with data mapping “challenges” to be completed before the workshop. Creative solutions to these challenges will have the opportunity to present to a national audience at the June 6\, 2022\, BRAIN Initiative Cell Census Network (BICCN) consortium meeting and participate in a published article detailing the challenge results.
URL:https://scienceinseattle.com/event/frameworks-for-brain-cell-type-definition-ontology-and-nomenclature-workshop-mapping-of-cell-type-data-3/
LOCATION:Online
ATTACH;FMTTYPE=image/png:https://scienceinseattle.com/wp-content/uploads/sites/4/2022/05/mappingdatabanner.png__800x800_q75_subsampling-2.png
END:VEVENT
END:VCALENDAR