Science in Seattle

Hansje Brinker Guild Beer & Bitterballen Event
2022-03-13 16:00 - 18:00 (America/Vancouver) | Queen Anne Beerhall, 203 W. Thomas St, Seattle, WA, 98119, United States
Please join the Hansje Brinker Guild at the Queen Anne Beerhall for bitterballen and beer to help us raise money for the Child Life Department at Seattle Children’s hospital.
This event is open to the public with kids activities provided by the Oranje School.
No admission fee. Purchase bitterballen from the guild once inside and beer and other food from Queen Anne Beerhall.
What are bitterballen, you ask? Only the most tasty Dutch bar snack and now it’s here for you to try!
While you’re at it, play some Dutch shuffleboard.
Proof of Covid vaccination is required (or a negative Covid test)
Parking is free in the parking lot next to the Queen Anne Beerhall, alternatively: street parking
Masks required, except when eating/drinking at your table.
We hope to see you there!

Date: Sunday, March 13, 2022 4:00 p.m. – 6:00 p.m.
Location: Queen Anne Beerhall
203 W. Thomas St
Seattle, WA 98119
Contact: elsebakker@gmail.com

Current Biology Seminar - Dr. Shawn Chavez
2022-03-15 12:00 - 13:00 (America/Vancouver) | Online
The Basic Sciences Division hosts a weekly Current Biology Seminar series where leading-edge researchers are invited from around the world to share their latest scientific breakthroughs. Lectures are typically every Tuesday and are held as virtual events.
Shawn Chavez, Ph.D.
Oregon National Primate Research Center
Division of Reproductive & Developmental Sciences
Oregon Health & Science University
Departments of Obstetrics & Gynecology, Molecular & Medical Genetics, and Biomedical Engineering
The Chavez Lab research interests focus on the use of real-time imaging and low-input next-generation sequencing to investigate the genetic, epigenetic, and chromosomal requirements of early embryogenesis and placentation in non-human primates and other mammals. In particular, her laboratory aims to determine how whole chromosomal abnormalities (aneuploidy) and sub-chromosomal instability may arise or be resolved during preimplantation development.
Seminar Title: Mechanisms of Chromosomal Instability and Preimplantation Embryo Loss Across Mammalian Species

Global Oncology Lecture Series
2022-03-21 08:00 - 09:30 (America/Vancouver) | Online
Benjamin O. Anderson, MD, FACS
Medical Officer, Cancer Control, World Health Organization and Professor of Surgery & Global Health Medicine, University of Washington
Past Chair and Director, Breast Health Global Initiative, Fred Hutchinson Cancer Research Center
Seminar Title: “Global Breast Cancer Initiative (GBCI): Breast Cancer as a Bridge to Global Cancer Control”

Science Says - Special Edition with Trevor Noah
2022-03-22 09:00 - 10:00 (America/Vancouver) | Online
Join us for a special edition of Science Says on Tuesday, March 22, with Trevor Noah! Our Hutch scientists will have a dynamic conversation with the comedian and host of “The Daily Show” about increasing access to the latest innovative research and care for cancer and COVID-19.
With:

Dr. Michele Andrasik, director of community engagement for the HIV Vaccine Trials Network and COVID-19 Prevention Network, who works to ensure that clinical trials include people from every background.
Dr. Rachel Issaka, holder of the Kathryn Surace-Smith Endowed Chair in Health Equity Research, who focuses on better ways to detect and stop colorectal cancer in the most vulnerable groups, including Black men and women.

SEP Virtual Field Trip: Campbell Lab
2022-03-22 16:00 - 17:00 (America/Vancouver) | Online
Virtual Field Trip to the Campbell Lab
Join us on March 22nd from 4-5 pm for our Hutch@Home Virtual Field trip to the Campbell lab!
The Campbell Lab is focused on understanding how cells communicate and interact with their surroundings. They study a family of receptors that are critical for accurate cell communication: they transverse the cell membrane and relay external signal into the cell, as well as internal signal out.

2022 From the Laboratory to Leadership – Spring Program (Day 3)
2022-03-23 09:30 - 15:30 (America/Vancouver) | Online
It’s an incredibly exciting time for the life science industry. Today, our clients are evolving at a tremendous pace and achieving levels of success that are incredible. Whether they are launching their first collaboration, entering the clinic or receiving regulatory approval for their first drug or medical device, managing growth and change are at the top of everyone’s mind. With this excitement, also comes stress, sweaty palms, sleepless nights, feelings of incompetence and increasing numbers of employee relations issues, as technically trained individuals find themselves promoted to management roles in order to meet the business needs of the organization.
Completely redesigned from the ground up, the 25th Anniversary Edition of From the Laboratory to Leadership, develops the skills and knowledge of first-time and developing managers in life science companies, taking them from competent technical managers to capable business leaders. Leveraging the knowledge gained from the original groundbreaking program, which has been delivered to over 7,500 leaders from over 700 of the industry’s leading life science companies, this entirely new program provides participants with the management foundation to successfully hire, develop, and deploy top talent in their organizations. Whether you are a start-up or a fully integrated company, the program is a “game changer” for your employees and your organization.
The program begins by providing the participants with the opportunity to define their personal leadership style as the result of exploring their leadership philosophies, strengths and personality type. These strengths and preferences are then mapped to the organizational needs, enabling each manager to define their program goals and to begin creating their professional development plan. Each plan is designed to provide the company with a minimum of a two time return on the program investment. Foundational and more advanced skills and tools are then introduced including goal setting for individual and project success, performance management of individuals and teams, priority management to enable focus and efforts to be targeted on the high impact areas, interviewing and selecting top performers and communicating effectively. Team development, delegation and the impact of emotional intelligence on performance are just a few of the additional areas that provide “ah ha” opportunities for everyone in the room.
The sessions fly by, as participants engage with one another as individuals, teammates, and sometimes as instructors. The use of learning pods, technology and your “companies as learning labs”, ensures participants establish and enhance their relationships in their workplaces, build peer relationships, gain insights into real time issues, goals and needs, and apply industry tested business solutions that impact your company’s performance and bottom line.
“The techniques we learned in this course helps our group be much more efficient and effective in our meetings and deadlines, while increasing communication and that makes other group members happier.” ~ Stuart Anderson, Research Associate II, NanoString Technologies
This four session program includes company and industry relevant case studies, practical and engaging exercises, down-loadable support tools for each session, and a manual designed to personalize the training for each participant. A tremendous value for a $2,795 investment per participant for Life Science Washington members and $3,295 for non members.
View syllabus and program overview.

Distinguished Seminar Series - Kenneth D. Harris
2022-03-24 10:30 - 11:30 (America/Vancouver) | Online
Transcriptomics has revealed the exquisite diversity of cortical inhibitory neurons, but it is not known whether these fine molecular subtypes have correspondingly diverse activity patterns in the living brain. Here, we show that inhibitory subtypes in primary visual cortex (V1) have diverse correlates with brain state, but that this diversity is organized by a single factor: position along their main axis of transcriptomic variation. We combined in vivo 2-photon calcium imaging of mouse V1 with a novel transcriptomic method to identify mRNAs for 72 selected genes in ex vivo slices. We used previously-defined transcriptomic clusters (Tasic et al, Nature 2018) to classify inhibitory neurons imaged in layers 1-3 into a three-level hierarchy of 5 Families, 11 Types, and 35 Subtypes. Visual responses differed significantly only across Families, with the Sncg Family showing notable suppression by visual stimuli. Modulation by brain state differed at all hierarchical levels, but a cell type’s brain state modulation and correlations with simultaneously recorded cells could be largely predicted from a single transcriptomic axis, the first transcriptomic principal component. Inhibitory Subtypes that fired more in resting, oscillatory brain states had narrower spikes, lower input resistance, weaker adaptation, and less axon in layer 1 as determined in vitro (Gouwens et al Cell 2020); Subtypes firing more during arousal had the opposite properties. The former Subtypes express more inhibitory cholinergic receptors, and the latter more excitatory cholinergic receptors in single-cell data. Thus, a simple principle may largely explain how diverse inhibitory V1 Subtypes shape state-dependent cortical processing.
Kenneth D. Harris studied mathematics at Cambridge University, did a PhD in robotics at UCL, then moved to Rutgers University in the United States for postdoctoral work in neuroscience. Before returning to UCL in 2012, he was Associate Professor of Neuroscience at Rutgers, and Professor of Neurotechnology at Imperial College London. He is currently Professor of Quantitative Neuroscience in the UCL Institute of Neurology. Together with Matteo Carandini he directs the Cortexlab.

SEP School Year Workshop: Elephants and Cancer Unit
2022-03-25 16:00 - 2022-03-26 18:00 (America/Vancouver) | Online
Elephants and Cancer Unit Workshop
Join us on March 25 and 26th for our two-day workshop covering our new Elephants and Cancer unit. This 4-lesson unit centers around the question: Why don’t elephants get cancer as often as humans? Your students will learn about cancer avoidance strategies in different animal species. Then, focusing on the p53 cancer avoidance protein, students will run a gel electrophoresis lab and model the protein. Note that this unit can be used in conjunction with our original Elephant Trunk unit or as a stand-alone unit.
The workshop will be held over Zoom from 4-6 pm PST on Friday, March 25th, and in-person, 9 am – 12 pm PST on Saturday, March 26th. Spots are available on a first-come-first-serve basis and we will be limiting workshop capacity to 10 participants due to the in-person session.

Innovating in Oncology: Meet the Startup Innovators Fueling the Future for Cancer Treatment
2022-03-30 13:30 - 14:30 UTC | Online
Some of tomorrow’s biggest breakthroughs in cancer treatment are in the works today in genomics startup labs across the US. In this Spring’s Genome Startup Day event, we are bringing together CEOs and leaders in the cancer genomics startup industry for a behind-the-scenes look at how emerging genomics technologies are taking aim at overcoming one of the most significant and deadly diseases in our world, and how these startup leaders are carving successful careers in the cancer tech landscape.
Phase Genomics is also honored to also welcome Dr. Greg Evans, National Cancer Institute Program Director and Team Leader, for a fireside chat with Phase Genomics CEO and CO-Founder Dr. Ivan Liachko. Their insights will shed light on the funding process behind emerging technologies and how to start on the road to success.
For more information and to register for this event, please visit the event website.

Variant Effect Seminar Series - Shawn Fayer and Marty Yang
2022-04-05 15:00 - 16:00 (America/Vancouver) | Online
April 5th Speakers:
Shawn Fayer Fowler and Starita labs, University of Washington
Presentation Date: April 05, 2022
Closing the gap: Systematic integration of multiplexed functional data resolves variants of uncertain significance in BRCA1, TP53, and PTEN
Shawn is a genetic counselor and Ph.D. candidate at the University of Washington co-advised by Doug Fowler and Lea Starita. His work focuses on the clinical integration of multiplexed functional assay data and the generation of multiplexible assays in pluripotent stem cells.
Marty Yang Greenberg lab, Harvard Medical School
Presentation Date: April 05 2022
Genetic dissection of enhancer function
Marty is a Ph.D. student in Michael Greenberg’s laboratory at Harvard Medical School. His work focuses on using a genetic variation to understand how transcription factors control cis-regulatory function in the native chromatin context.

2022 From the Laboratory to Leadership – Spring Program (Day 4)
2022-04-06 09:30 - 15:30 (America/Vancouver) | Online
