Dr. Stanley Gartler was born on June 9, 1923, in Los Angeles, California to Romanian immigrant parents. During WWII, he flew combat with the 9th Air Force as a radio operator and machine gunner. Having an early interest in agriculture, Gartler worked on a farm after earning his undergraduate degree at UCLA and studied genetic plant breeding in graduate school…
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Scientific research breakthroughs are often achieved when many different scientists, in different labs and organizations, work together on a single task. That happened at the turn of the 21st century with the Human Genome Project, where human DNA was mapped for future reference and is now key to many breakthroughs in medicine. This is happening again, with a similarly visionary…
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A discovery about bacterial physics could point to a new way to develop antibiotics. The finding is likely to apply to approximately half of the world’s bacteria — potentially including antibiotic-resistant strains — said K.C. Huang, Ph.D., senior author on the study, which was published today in the journal Nature. Huang and his colleagues found that the outer layer of E. coli behaves very…
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A Phosphatidylinositol 3-Kinase Effector Alters Phagosomal Maturation to Promote Intracellular Growth of Francisella

Many pathogenic intracellular bacteria manipulate the host phago-endosomal system to establish and maintain a permissive niche. The fate and identity of these intracellular compartments is controlled by phosphoinositide lipids. By mechanisms that have remained undefined, a Francisella pathogenicity island-encoded secretion system allows phagosomal escape and replication of bacteria within host cell cytoplasm. Here we report the discovery that a substrate…
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