Eric Dishman is a living, breathing advertisement for the ambitious experiment he’s in charge of, the National Institutes of Health’s “All of Us” drive to collect and analyze the genomes of a million Americans. If it weren’t for the fact that he had his genome sequenced seven years ago, he probably would not be living and breathing. Back then, he was struggling…
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Two of the world’s largest biomedical research funders have backed a plan to make all papers resulting from work they fund open access on publication by 2020. On 5 November, the London-based Wellcome Trust and the Bill and Melinda Gates Foundation in Seattle, Washington, announced they were both endorsing ‘Plan S’, adding their weight to an initiative already backed by 13 research funders across…
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What would the world look like if there was a clear path for game-changing innovation to transform global health? And what if that path was faster, more efficient, more reliable – more local – than ever before? Innovation is our best bet to truly bend the curve in global health—to save and improve more lives, eliminate more diseases, and deliver on the…
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An international team of scientists has completed the first 3D virtual reconstruction of the ribcage of the most complete Neanderthal skeleton unearthed to date, potentially shedding new light on how this ancient human moved and breathed. The team, which included researchers from universities in Spain, Israel, and the United States, including the University of Washington, focused on the thorax —…
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The first locally acquired case of West Nile virus in a King County resident has been reported by Public Health — Seattle & King County. The virus is transmitted to humans by mosquitos, and most people who are infected don’t develop any symptoms. But, in rare cases, people can develop a serious illnesses affecting the brain, according to the Centers for Disease Control and Prevention. Justin…
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Metastatic Breast Cancer Research Takes the Stage

The keynote speaker got the flu and the morning sunshine turned to sloppy rain, but hope, health and science continued to shine brightly at the third annual Northwest Metastatic and Lobular Breast Cancer Conference, held Friday and Saturday in Seattle. Created for patients by patients, the conference was facilitated by funding from Komen Puget Sound and a slew of sponsors,…
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For the first time scientists have successfully designed non-local beta-sheet proteins from scratch. These structures will be essential for creating artificial antibodies and active sites for enzymes and ligand-binding proteins, which are critical to many processes in living things. The advance opens the way for custom-designing complex proteins for therapeutics, diagnostics and industrial enzymes, said Enrique Marcos, who with Tamuka…
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Our team focuses on pediatric brain tumor therapeutics and the discovery of novel peptide therapeutics for a variety of diseases.  We discovered “Tumor Paint”, a scorpion-derived peptide that delivers fluorescent markers to cancer cells. Stemming from that work, the investigational agent Tozuleristide (Blaze Bioscience) is now entering a nationwide clinical trial that could potentially lead to FDA registration.  We are now using the patient-derived mouse models described in the Nature Medicine paper to prioritize treatment strategies for the types of brain tumors that most often lead to death in children...
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It’s notable that the newest class of Allen Distinguished Investigators, announced today by the Paul G. Allen Frontiers Group, includes researchers who are developing new treatments for lymphoma. Lymphoma is the type of blood cancer that led to the death of Microsoft co-founder Paul Allen, the namesake and funder of the research program. The decision to focus on that disease — along with…
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Automated Quantification of Bioluminescence Images

We developed a computer-aided analysis tool for quantitatively determining bioluminescent reporter distributions inside small animals. The core innovations are a body-fitting animal shuttle and a statistical mouse atlas, both of which are spatially aligned and scaled according to the animal’s weight, and hence provide data congruency across animals of varying size and pose. In conjunction with a multispectral bioluminescence tomography…
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