The US state of Washington, in the Pacific Northwest, was once the epicentre of the information-technology world, thanks to Microsoft and its founder, Seattle-born Bill Gates — until the dotcom boom sent investors down the coast to Silicon Valley. Now, Gates and other high-profile Microsoft alumni, along with other wealthy donors, are elevating the state as a major player in…
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James Watson, the Nobel Prize-winning DNA scientist who lost his job in 2007 for expressing racist views, was stripped of several honorary titles Friday by the New York lab he once headed. Cold Spring Harbor Laboratory said it was reacting to Watson’s remarks in a television documentary aired earlier this month. In the film, Watson said his views about intelligence…
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Dr. Kristin Anderson, a postdoctoral research fellow in Dr. Philip Greenberg’s lab at Fred Hutchinson Cancer Research Center, has received the Ann and Sol Schreiber Mentored Investigator Award of $75,000 for one year from the Ovarian Cancer Research Alliance. The funding will support Anderson’s research in developing strategies to improve the ability of the immune system’s T cells to kill ovarian cancer. Anderson…
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A research team led by Jessica A. Hamerman, PhD, at Benaroya Research Institute at Virginia Mason (BRI), has discovered a unique type of cell and its association with a life-threatening complication of viral and autoimmune diseases. The team’s discovery, published in the journal Science, could lead to new treatments for a deadly form of inflammation in children with systemic juvenile idiopathic arthritis…
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Scientists at UW Medicine’s Institute for Protein Design  have created a new protein that mimics the action of a key immune regulatory protein, interleukin 2 (IL-2).  IL-2 is a potent anticancer drug and an effective treatment for autoimmune disease, but its toxic side effects have limited its clinical usefulness. In a paper in the Jan. 10 issue of the journal Nature, the researchers report using…
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Microsoft is seeking new research partners to join its T-cell Antigen Map project — an ongoing effort to map the human immune system. The project launched one year ago, when Microsoft partnered with Adaptive Biotechnologies, a Seattle-based biotech company. Under the partnership, researchers at Microsoft are using artificial intelligence to help analyze Adaptive Biotechnologies’ high-throughput sequencing and bioinformatics data on T-cell and B-cell receptors,…
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Nerve agents are a class of organophosphorus compounds (OPs) that blocks communication between nerves and organs. Because of their acute neurotoxicity, it is extremely difficult to rescue the victims after exposure. Numerous efforts have been devoted to search for an effective prophylactic nerve agent bioscavenger to prevent the deleterious effects of these compounds. However, low scavenging efficiency, unfavorable pharmacokinetics, and…
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For 30 years, scientists have been trying to unleash the promise of Interleukin-2 (IL-2), a powerful protein that fights cancer but is highly toxic. Researchers at the University of Washington may finally have done it, and they’re launching a startup to make a commercial version. The breakthrough is described in a paper published in the journal Nature by researchers at the Institute for…
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The Vaginal Microbiome of Transgender Men

Hormonal changes influence the composition of vaginal flora, which is directly related to the health of an individual. Transgender men prescribed testosterone experience a vaginal hormone composition that differs from cisgender women. To the author’s knowledge, there are no clinical studies evaluating the influence that testosterone administration has on the vaginal microbiome. Vaginal swabs were self-collected by a cohort of…
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