Metagenomic sequencing is a promising approach for identifying and characterizing organisms and their functional characteristics in complex, polymicrobial infections, such as airway infections in people with cystic fibrosis. These analyses are often hampered, however, by overwhelming quantities of human DNA, yielding only a small proportion of microbial reads for analysis. In addition, many abundant microbes in respiratory samples can produce large…
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Miranda Howe, a junior at the UW, has been feeding the hydras for UW associate professor Martha Bosma’s research group since spring of her freshman year. These hydras, however, are not mythical many-headed monsters, but rather freshwater relatives of anemones. Hydras are simple animals with only two layers of cells that can regenerate after bisection. They are named after an analogous monster from…
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As thousands of researchers from around the globe converge on Seattle for a conference on HIV/AIDS, top health officials in the United States are preparing to launch an ambitious new program aimed at eliminating new infections in the U.S. by 2030. In advance of the Conference on Retroviruses and Opportunistic Infections, or CROI, which opened at the Washington State Convention Center…
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The rise in multi-drug resistant (MDR) and extremely drug resistant (XDR) strains of Mycobacterium tuberculosis (MTB) has become a major cause of global health concern for treating tuberculosis. The number of worldwide deaths caused by tuberculosis has surpassed HIV/AIDS, stressing the sense of urgency for finding effective new drugs to fight MTB. In a landmark study published today in Molecular Systems Biology, researchers at ISB,…
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We are primarily interested in understanding how HIV is transmitted and in helping to define ways to prevent transmission and disease, primirily focused on understanding immune mechanisms that can block HIV. Our work focuses on HIV in highly vulnerable populations, including women and infants as these are most relevant to HIV prevention and we collaborate with investigators in Seattle and Kenya for these studies....
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Dr. Veena Shankaran named 2019 Leader in Health Care

Dr. Veena Shankaran of Fred Hutchinson Cancer Research Center was honored Thursday with a Gold Award for Achievement in Medical Research at Seattle Business magazine’s 2019 Leaders in Health Care Awards banquet at the Embassy Suites by Hilton in Seattle. Shankaran is co-director of the Hutchinson Institute for Cancer Outcomes Research, or HICOR, and an oncologist who treats patients with gastrointestinal cancers. She is…
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Getting sick is a bit of a game of chance: brushing by the wrong person, skimming a dirty table, grabbing the wrong towel at the gym. However, it is not as much of a dice roll as many believe. An individual’s lifestyle and habits play a role, and so do genetics. While all human beings share 99.9 percent of their…
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Factors associated with durable remission after CD19 chimeric antigen receptor (CAR)-modified T cell immunotherapy for aggressive B-cell non-Hodgkin lymphoma (NHL) have not been identified. We report multivariable analyses of factors impacting response and progression-free survival (PFS) in aggressive NHL patients treated with cyclophosphamide and fludarabine (Cy/Flu) lymphodepletion followed by 2×106 CD19 CAR-T cells/kg. The best overall response rate (ORR) was 51%,…
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It was a tight race for the 2018 DJC Building of the Year. How tight? Six votes separated first and second place. And the winner is: UW Life Sciences Building. Runner-ups were F5 Tower/The Mark and Jordan Schnitzer Museum of Art. Honorable mentions go to Denny Substation, Pacific Seas Aquarium and Stratus. The UW project got 16 percent of the…
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