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Biostatistics Seminar Series
November 10, 2021
The Fred Hutch Biostatistics Program hosts seminars featuring presentations by Hutch and outside scientists to share their latest developments and recent research. Each seminar includes an hour-long presentation and discussion during which speakers showcase their work and findings.
This seminar will be held on Zoom due to the COVID-19 pandemic.
The T cell repertoire is the collection of all the different T cell clones in the immune system. Due to the critical roles that T cells play in multiple diseases, understanding the dynamics and signatures of the T cell repertoire has become increasingly important. There is a growing consensus that TCR repertoire could be serving as the next important biomarker for disease diagnosis and prognosis. However, due to the hyper-diversity of the T cell receptors and the lack of knowledge of their antigen-specificities, the analysis of the TCR repertoire is parable to reading a book without words. Hence, extracting meaningful information from the TCR repertoire of healthy/diseased individuals has become one of the top priorities. Our lab is committed to developing novel computational methods to investigate human TCR repertoires. In this talk, I will cover three of our recent methods, iSMART (Zhang et al., 2020, Clinical Cancer Research), DeepCAT (Beshnova et al., 2020, Science Translational Medicine) and GIANA (Zhang et al., 2021, Nature Communications), and progressively illustrate how we developed a novel diagnostic biomarker out of the TCR repertoire data for early cancer and other disease detections.