Celiac disease, like all autoimmune diseases, has no cure. People with the condition must adhere to a strict gluten-free diet or face symptoms like nausea, vomiting, ulcers and intestinal damage. This means cutting out breads, pastas, anything that contains flour and many sauces and seasonings. Living with this condition often means constant anxiety about eating, and makes things like parties…
The SARS-CoV-2 virus is causing a global pandemic and cases continue to rise. Most infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can induce persistent immune memory that could contribute to immunity. We performed a longitudinal assessment of individuals recovered from mild COVID-19 to determine if they develop and sustain multifaceted SARS-CoV-2-specific immunological…
The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, today announced the clinical investigators and institutions that will lead four NIH HIV clinical trials networks over the next seven years to conduct the innovative, efficient clinical research needed to accelerate progress against the HIV pandemic. NIAID also awarded grants to 35 U.S. and international institutions…
While the effect of bacterial molecules on the host immune system is well studied, how host factors affect the expression of bacterial molecules is less appreciated. Here we uncover the impact of inflammasome activation and type 1 interferon on the expression of bacterial flagellin. Flagellin induces NLRC4 inflammasome-mediated pyroptosis causing clearance of Salmonella. We show that inflammasome activation also produces lysophospholipids…
AMD3100 (plerixafor) is a vital component of many clinical and pre-clinical transplant protocols, facilitating harvest of hematopoietic stem and progenitor cells through mobilization into the peripheral blood circulation. Repeat mobilization with AMD3100 is also necessary for many patients with suboptimal first stem cell collection or those requiring repeat transplantation. In this study we investigated the mobilization efficacy of repeated AMD3100…
Dr. Deborah Donnell, a biostatistician at Fred Hutchinson Cancer Research Center, today was named a Fellow of the American Association for the Advancement of Science. The honor, a mark of distinction from the AAAS, hails Donnell for her contributions to science in a field where she plays a pivotal role in analyzing results of clinical trials of drugs that can prevent…
ISCRM faculty member Dr. Vincenzo Cirulli, MD, PhD, has been elected to the Board of Directors of the Diabetes Research Connection (https://diabetesresearchconnection.org/), a non-profit organization devoted to support early-career scientists to perform innovative research designed to prevent and cure Type 1 diabetes. Over the past three years, the Diabetes Research Connection has funded more than 30 young scientists with awards ranging from…
When immunologist Dr. Stanley Riddell was refining the genetic engineering of T cells as a potential treatment for lymphomas in 2011, a rising entrepreneur from Ireland, Dr. David Burke, was moving with his wife and their young son to Silicon Valley to take a position as director of engineering at Google. Burke is now vice president of engineering at Google,…
More than 5 million Americans are living with Alzheimer’s disease, and that number is expected to nearly triple by 2050. Alzheimer’s is the sixth leading cause of death in the U.S., yet treatments for it and other forms of dementia are largely ineffective. To date, there have been an estimated 400 trials and experimental Alzheimer’s treatments that have failed, suggesting there is limited…
ElitechGroup MDx submitted a coronavirus test manufactured at its facility in Bothell to the Food and Drug Administration for emergency use authorization, the company announced this week. ElitechGroup’s product is a four-in-one diagnostic test that detects and differentiates the coronavirus from other common flus, such as influenza A and B and respiratory syncytial virus. The test requires a sample from…
