Seattle-based biotech Alpine Immune Sciences (Nasdaq: ALPN) is raising $100 million through an underwritten public offering. With the new funding, announced Tuesday, Alpine co-founder and CEO Mitchell Gold said the biotech now has more than three years of runway. He added that the company, which now has about 130 people, has grown 65% over the past nine months, but he didn’t provide…
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Saliva testing is emerging as a potential option to detect oral cavity cancer – a condition often difficult to identify early and which usually becomes a painful ordeal for patients as it progresses. “The way it’s diagnosed is typically with a biopsy, and that biopsy can be painful,” said Dr. Brittany Barber, a head and neck surgeon at UW Medicine. “Other diagnostic techniques…
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Two years after scientists showed that an experimental gene therapy for herpes can knock out most latent infection in mice, new tests reveal that it also suppresses the amount of transmissible virus shed by the treated animals. It is encouraging news from researchers at Fred Hutchinson Cancer Center, where laboratory studies aimed at curing herpes simplex virus infections have continued…
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Renowned UW Bioengineer Suzie Pun Named Next MolES Institute Director

Suzie Hwang Pun, Washington Research Professor of Bioengineering, has been named the new Director of the Molecular Engineering & Sciences Institute, effective July 1, 2023. The current Director, Pat Stayton, will continue to serve until Suzie’s appointment begins. Pun brings a depth of academic leadership and industry experience and a vision for the future of MolES that will serve the Institute…
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Drs. Vincenzo Cirulli, associate professor and Laura Crisa, associate professor (Metabolism, Endocrinology and Nutrition), and Hannele Ruohola-Baker and Shiri Levy (Biochemistry) have received the first state-funded 2022-2023 ISCRM Team Award (ITA). Funding will allow the researchers to develop and validate a multidisciplinary approach to generate clinically applicable pancreatic tissue for transplant in diabetes treatment. The goals of the ITA-funded effort…
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The National Cancer Institute awarded the Institute for Systems Biology (ISB) a 5-year, $13 million grant to lead a collaborative cancer center and study sequential combinations of targeted inhibitors and immunotherapies. The program – called Spatiotemporal Tumor Analytics for Guiding Sequential Targeted Inhibitor-Immunotherapy Combinations, or ST-Analytics – is designed to determine if the treatments yield greater patient benefit when administered…
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Seattle’s Allen Institute will spearhead a project to create an atlas of the cells in the human brain as part of $173 million in new funding from the U.S. National Institutes of Health awarded to the institute and its collaborators. The five-year project, announced Thursday, builds on the Allen Institute’s previous endeavors mapping the location, identity and function of cells…
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Aptamer-Based Traceless Multiplexed Cell Isolation Systems

In both biomedical research and clinical cell therapy manufacturing, there is a need for cell isolation systems that recover purified cells in the absence of any selection agent. Reported traceless cell isolation methods using engineered antigen-binding fragments or aptamers have been limited to processing a single cell type at a time. There remains an unmet need for cell isolation processes…
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On Aug. 11, LifeCenter Northwest, the Organ Procurement Organization for Washington, and UW Medicine’s heart transplant team together facilitated the Pacific Northwest’s first donation-after-circulatory-death (DCD) heart transplant. The patient, Ryan Stovall, 48, a resident of Beaver Creek, Oregon, is recovering well in Seattle. For decades, only donor hearts from patients who experienced brain death have been transplanted; hearts from patients who…
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