BBI Faculty Conversations: Dr. Manu Setty

The Brotman Baty Institute was recently joined by BBI Member Dr. Manu Setty, assistant professor in the Herbold Computational Biology Program at Fred Hutchinson Cancer Center. BBI: How did you get interested in your area of research? Dr. Setty: Going all the way back to high school, I had a passing interest in both molecular biology and computer science. In India…
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Yazdan Awarded AHA Funding for Innovative Stroke Treatment

With a promising approach to drive brain repair and recovery following a stroke, University of Washington neuroengineer Azadeh Yazdan has earned the American Heart Association (AHA) Career Development Award. Yazdan’s neural engineering technologies and new brain stimulation-based therapies have the potential to help restore function and movement in people who have had a stroke – something that happens every 40 seconds in…
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The authors evaluate the efficacy of guselkumab for the treatment of active psoriatic arthritis (PsA) utilizing composite indices. Data were pooled from the Phase 3 DISCOVER-1 (N = 381) and DISCOVER-2 (N = 739) studies. In both studies, patients were randomized 1:1:1 to subcutaneous guselkumab 100 mg every 4 weeks (Q4W); guselkumab 100 mg at week 0, week 4, then Q8W; or placebo Q4W with crossover to…
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BWF Announces The 2022 Career Awards For Medical Scientists

The Burroughs Wellcome Fund’s Board of Directors is pleased to announce the 2022 award recipients for the Career Awards for Medical Scientist program. BWF’s investment of 9.8 million dollars to this year’s cohort represents its largest commitment to date. Among the recipients is Dr. Jay Sarthy of Fred Hutch, for his work “Interrogation of Pathological Histone Dynamics to Identify Drivers…
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A University of Washington program to support STEM students from low-income and underserved backgrounds is now nine years old. And it aims to spread the model to other institutions. The Washington State Academic RedShirt program (STARS) takes a cue from college sports, where “redshirting” enables an extra year of eligibility for athletes. Students sign up for an extra year at the UW,…
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SARS-CoV-2 has evolved variants with substitutions in the spike receptor-binding domain (RBD) that impact its affinity for ACE2 receptor and recognition by antibodies. These substitutions could also shape future evolution by modulating the effects of mutations at other sites—a phenomenon called epistasis. To investigate this possibility, we performed deep mutational scans to measure the effects on ACE2 binding of all…
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Organizer Dr. Fritz Roth and keynote speakers Drs. Clare Turnbull and Doug Fowler offer their observations and insights of the event and suggestions for the 2023 symposium to be held in the U.K. The fifth annual Mutual Scanning Symposium was held June 13, 14, and 16 in Toronto and online. Organizer Dr. Fritz Roth and keynote speakers Drs. Clare Turnbull…
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Vascular dysfunction. Ice melt in Antarctica. Chronic liver disease. University of Washington graduate students are finding solutions to these problems — and many more — with the support of Washington Research Foundation. And thanks to the foundation’s most recent gift, emerging scientists at the UW and Washington State University will be supported for years to come. Washington Research Foundation (WRF)…
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Kubota Vision, a clinical-stage ophthalmology company and wholly-owned subsidiary of Kubota Pharmaceutical Holdings, announced today the completion of the Phase III clinical trial investigating emixustat hydrochloride (“emixustat”) in patients with macular atrophy secondary to Stargardt disease. The study was a multi-center, randomized, double-masked, and placebo-controlled Phase III clinical study in which subjects were randomly assigned to emixustat 10 mg or…
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