A single brain is unfathomably complex. So brain researchers, whether they’re looking at datasets built from 300,000 neurons in 81 mice or from MRIs of 1,200 young adults, are now dealing with so much information that they must also come up with new methods to comprehend it. Developing new analysis tools has become as important as using them to understand…
This September marks the 60th anniversary of Newborn Screening (NBS), a landmark achievement that the US Centers for Disease Control and Prevention (CDC) considers one of the ten greatest public health achievements worldwide. Today, newborns in all 50 states are screened within the first few days of life for a panel of 34 rare conditions. Infants born with one of…
Dr. Mary (Nora) Disis, professor (Hematology and Oncology) is the 2024 recipient of the Creative Invention Award by the American Chemical Society (ACS). She is being recognized for her work in developing vaccines for the prevention and treatment of cancers. Disis is the founder and director of the University of Washington Cancer Vaccine Institute. Dr. Disis is also presenting “What…
Plenty of high school students plan to make careers out of coding when they graduate from college. And plenty of other students are probably planning careers as cancer-research scientists. But how many are planning on doing both at once? “Coding for Cancer,” a program from the Seattle-based Fred Hutch Cancer Center, aims to let students know that computational research in…
UW’s Dr. Danny Miller (M.D., Ph.D.) specializes in long-read genome sequencing, unsolved genetic disorders, and clinical genetic testing in his research and clinical practice at Seattle Children’s Hospital. He is the scientific advisor to the upcoming long-read symposium BBI is hosting November 15 at the Fred Hutchinson Cancer Center. The primary goal of the symposium is to bring together Seattle-area…
UW Department of Bioengineering Assistant Professor Patrick M. Boyle will be honored at the 2023 Biomedical Engineering Society (BMES) annual meeting as a Young Innovator in Cellular and Molecular Bioengineering. The Young Innovators award is issued by Cellular and Molecular Bioengineering (CMBE), a journal focused on “research that studies how cellular behavior arises from molecular-level interactions to tackle the challenge…
The impetus for this database was to improve our ability to offer personalized medicine to individuals we are seeing at the UW and Fred Hutch Genetics Clinics. These two genetics clinics see over 5,000 patients annually with rare or undiagnosed conditions. Although most of these individuals will get genetic testing, for many we will only identify a Variant of Uncertain…
Metabolic assays serve as pivotal tools in biomedical research, offering keen insights into cellular physiological and pathological states. While mass spectrometry (MS)-based metabolomics remains the gold standard for comprehensive, multiplexed analyses of cellular metabolites, innovative technologies are now emerging for the targeted, quantitative scrutiny of metabolites and metabolic pathways at the single-cell level. In this review, we elucidate an array…
To improve the understanding of chemo-refractory high-grade serous ovarian cancers (HGSOCs), we characterized the proteogenomic landscape of 242 (refractory and sensitive) HGSOCs, representing one discovery and two validation cohorts across two biospecimen types (formalin-fixed paraffin-embedded and frozen). We identified a 64-protein signature that predicts with high specificity a subset of HGSOCs refractory to initial platinum-based therapy and is validated in two…
In a Q&A, Dr. Ramesh Rengan outlines the strategy, mission and goals for research and care. Fred Hutchinson Cancer Center launched a new Division of Radiation Oncology in July 2023 led by Ramesh Rengan, MD, PhD, Senior Vice President and Professor in the Clinical Research Division. The establishment of the new division is part of an overall strategy to synchronize…
