Neoleukin Therapeutics, Inc., “Neoleukin” (NASDAQ:NLTX), a biopharmaceutical company utilizing sophisticated computational methods to design de novo protein therapeutics, today announced dosing the first patient in a Phase 1 trial of NL-201 for advanced solid tumors. NL-201 is a de novo protein designed to mimic the therapeutic activity of natural cytokines IL-2 and IL-15. The Phase 1 study will be conducted at multiple sites in Australia and North America. The…
Three highly pathogenic β-coronaviruses have crossed the animal-to-human species barrier in the past two decades: SARS-CoV, MERS-CoV and SARS-CoV-2. To evaluate the possibility of identifying antibodies with broad neutralizing activity, we isolated a monoclonal antibody, termed B6, that cross-reacts with eight β-coronavirus spike glycoproteins, including all five human-infecting β-coronaviruses. B6 broadly neutralizes entry of pseudotyped viruses from lineages A and…
B cell responses to tumor antigens occur early in breast tumors and may identify immunogenic drivers of tumorigenesis. Sixty-two candidate antigens were identified prior to palpable tumor development in TgMMTV-neu and C3(1)Tag transgenic mouse mammary tumor models. Five antigens (VPS35, ARPC2, SERBP1, KRT8, and PDIA6) were selected because their decreased expression decreased survival in human HER2 positive and triple negative…
Researchers looking to help people suffering from addiction, depression, and pain are studying how certain brain neurons operate to see if they can be controlled. In a paper published May 11 in Neuron, researchers at the University of Washington School of Medicine and Washington University in St. Louis, along with several other universities, successfully used a protein called parapinopsin to turn off…
Researchers at the Allen Institute are on a quest to understand everything they can about the microscopic defense system coursing through our blood — our immune cells. The human immune system touches all aspects of health and disease, as the last year’s global pandemic has all too painfully highlighted. But many characteristics of the system remain poorly understood, especially when…
The Infectious Disease Research Institute (IDRI), Duke Human Vaccine Institute, and 3M have collaborated to create a vaccine candidate with potential to provide protection against multiple variants of SARS-CoV2, as well as other coronaviruses. Study results published in the May 10th edition of Nature show the vaccine candidate, which combines a nanoparticle developed by a Duke-led research team with IDRI’s…
Dr. Yingye Zheng, a professor of biostatistics in Fred Hutchinson Cancer Research Center’s Public Health Sciences Division, has been elected as a fellow of the American Statistical Association. Zheng joined Fred Hutch in 2003 and is an affiliate professor of biostatistics in the University of Washington School of Public Health and Community Medicine. She was selected for the prestigious fellowship for…
Seattle Children’s today announced that Anu and Satya Nadella and their family have generously committed $15 million to advance precision medicine neurosciences and youth mental health care at Seattle Children’s, and to help provide equitable access to care for every family and community. Seattle Children’s today announced that Anu and Satya Nadella and their family have generously committed $15 million…
Early in the pandemic, it was thought that the SARS-CoV-2 virus attacked blood vessels and the heart with just as much vigor as it did the lungs. But now, just over a year later, a new study shows that the virus attacks the lungs and the lining of lung tissue, and that injury to blood vessels may be less common. In research published…
The Institute for Stem Cell and Regenerative Medicine (ISCRM) is pleased to welcome a new faculty member, Thelma Escobar, who this month joins the Department of Biochemistry as an Assistant Professor. Escobar’s lab will combine stem cell biology, immune biology, and biochemistry to investigate how histone inheritance preserves chromatin domains, to identify mechanisms for cell fate determination, and to answer…
