Joris Vermeesch, PhD, Professor, Laboratory of Cytogenetics and Genome Research, Department of Human Genetics, Faculty of Medicine, KU Leuven, Belgium will discuss how he and his lab developed novel genomic approaches to genotype, haplotype and transcript profile single cells. Concurrent haplotyping and copy number analyses has not only uncovered the range but also an unexpected pervasive incidence of chromosomal anomalies in both zygotes, cleavage stage embryos, blastocysts and placenta. Monitoring the frequency of different chromosomes as well as the parental origin of the rearrangements during embryonic and fetal development has provided fundamental novel insights in genome biology. Dr. Vermeesch will present an overview of their recent findings in the scope and the origins of (segmental) chromosomal aneuploidies.