Our Science Matters seminars highlight exciting research in genetics, genomics, and evolutionary biology with important societal impact. Topics include research on the genetics of ethnically diverse populations, diseases afflicting vulnerable or underserved groups, and efforts to expand the diversity (broadly defined) of research subjects or the scientific workforce. The cause of many severe disabilities was long considered a mystery, but scientists now understand that genetic and genomic mutations lead to many of these conditions. In this seminar, Dr. Brunner will discuss how mutation and sexual selection shape our genetic landscape today.