Dr. Greenberg’s research has focused on elucidating fundamental principles of T-cell and tumor interactions; developing cellular and molecular approaches to manipulate T-cell immunity; and translating insights to the clinic enabling adoptive therapy with genetically engineered T cells. Internationally recognized as a leader in the cancer immunology field, his laboratory performed some of the earliest studies focused on how immune T…
A team led by two UW researchers has found that a transplant drug with anti-aging properties can regenerate bone and decrease gum inflammation, pointing the way toward new treatments for common dental problems in aging patients. Dr. Jonathan An and Dr. Matt Kaeberlein of the School of Dentistry, along with their colleagues across the country, have been studying rapamycin. Rapamycin…
Stephanie Lee, MD, MPH, a highly regarded expert in graft-versus-host disease as well as blood and bone marrow diseases, will serve as president of the American Society of Hematology (ASH) for a year-long term through December 2020. Dr. Lee is a member and associate director of the Clinical Research Division at Fred Hutchinson Cancer Research Center in Seattle, where she…
Life Science Washington, the state’s life science trade association, announced the addition of three new board members in 2020, and new leadership on the Executive Committee. Margaret McCormick, PhD, Executive Director and Chief Operating Officer, Benaroya Research Institute at Virginia Mason, and Vice President of Research for Virginia Mason Medical Center will serve as Board Chair for 2020-2022. She…
Below are summaries of recentFred Hutch research findings with links for additional background and media contacts. Immunotherapy Scientists show thin metal mesh loaded with T cells shrinks solid tumors What if a metal that’s already used to repair broken bones, straighten teeth and keep arteries from clogging could also be used to stop your cancer from spreading? New findings…
A new technique reported in Science this week overcomes several limitations of typical high-throughput chemical screens conducted on cell samples. Such screens are commonly used to try to discover new cancer drugs, and in many other biomedical applications. Most current screens of this nature offer either a coarse readout, such as of cell survival, proliferation or alterations in cell shapes, or only a…
Know someone with a bad case of acne? Someday, perhaps, physicians will treat it with swabs of healthy skin microbiome rather than with an antibiotic. The idea parallels the highly successful strategy of transplanting fecal microbiota to treat Clostridioides difficile (C. diff.), a stubborn bacterial infection of the colon. By introducing healthy microbes into an environment that is out of…
Why do some strings of genetic code remain virtually unchanged despite tens of millions of years of evolutionary divergence? A newly published study that takes advantage of the gene-editing technique known as CRISPR has found that at least some of those DNA strings are essential to keep healthy cells growing and block the growth of tumor cells. The research, published today…
Phase Genomics, Inc., the biotech leader providing proximity-ligation next-generation sequencing (NGS) solutions for metagenome assembly, today announced the award of a $1.5MM National Institutes of Allergy and Infectious Diseases (NIAID) grant to develop a low-cost platform for targeted detection of antimicrobial resistance mobile elements and their hosts in uncultured microbial communities. Phase Genomics will develop a rapid antimicrobial resistance (AMR) element…
The Immune Tolerance Network (ITN) opened the BEAT-MS clinical trial for enrollment. BEAT-MS or “Best Available Therapy vs. Autologous Hematopoietic Stem Cell Transplant (AHSCT) for MS” will investigate high dose immunosuppression followed by AHSCT – a type of transplant using a patient’s own immune stem cells – compared to the best medical treatment currently available for multiple sclerosis (MS) in…