Publications of the Week tRNA Dosage Regulates Lineage Dependency and Resistance in Prostate Cancer Kim, Y., et al. | October 19, 2026 Lineage plasticity underlies therapeutic resistance in cancer1,2, yet the translational mechanisms that enable this phenotypic…karnottOctober 19, 2026 Read More
Publications of the Week A DNA Typewriter Records the Cell Lineage History of a Mouse, From Zygote to Late Organogenesis Yu, Q., et al. | October 14, 2026 Mammalian biology unfolds over time, within tissues and organs opaque to our eyes and instruments.…karnottOctober 14, 2026 Read More
Publications of the Week CD4 T Cells Convert Transient Responses to KRAS Inhibition to Durable Remissions in Pancreatic Cancer Qiang, L., et al. | October 7, 2026 Pancreatic ductal adenocarcinoma (PDAC) is refractory to most therapies, including immunotherapies, for which reinvigoration of…karnottOctober 7, 2026 Read More
Publications of the Week Mechanotransduction of Magnetically Applied Forces Leads to Mechanical Stiffening of Platelet-Rich Plugs Taparia, N., et al. | September 30, 2026 The mechanobiology of platelets governs early hemostasis, where their contractile forces compact and stiffen the…karnottSeptember 30, 2026 Read More
Publications of the Week Mutational Constraints on RSV F and Its Neutralization by Antibodies Simonich, C., et al. | September 22, 2026 New antibodies targeting the F protein of respiratory syncytial virus (RSV) have substantially reduced infant…karnottSeptember 22, 2026 Read More
Publications of the Week Evolution and Heterogeneity of Lethal Metastatic Bladder Cancer Subtypes Itagi, P., et al. | September 18, 2026 Histological variation is a prognostic feature of metastatic urothelial cancer1,2,3, but its evolutionary trajectory remains…karnottSeptember 18, 2026 Read More
Publications of the Week Rapid, HIF-1α-Independent, Response of VEGF Secretion to Decreased O2 in Mouse Retina Kamat, V., et al. | September 15, 2026 Secretion of Vascular endothelial growth factor-A (VEGF) is considered to be controlled by transcriptional activation…karnottSeptember 15, 2026 Read More
Publications of the Week A Distinct Effector B Cell Population Drives Autoantibody Production in SARS-CoV-2 Infection Yuan, D., et al. | September 7, 2026 Autoantibodies (autoAbs) are linked to mortality and Long COVID, yet their cellular origins remain unclear.…karnottSeptember 7, 2026 Read More
Publications of the Week Monocytic Niches Escape T Cell Surveillance and Promote Mycobacterium tuberculosis Persistence in Lymph Nodes Shamskhou, E., et al. | September 2, 2026 Lung-draining mediastinal lymph nodes (medLNs) are critical for Mycobacterium tuberculosis (Mtb) pathogenesis, serving both as…karnottSeptember 2, 2026 Read More
Publications of the Week Multiple Myeloma and Therapy Reshape the Bone Marrow Niche to Durably Constrain Immune Reconstitution and Vaccine Responsiveness Chander, A., et al. | August 31, 2026 Infections are the most common cause of non-relapse mortality in multiple myeloma (MM), but the…karnottAugust 31, 2026 Read More