One of the interests of our lab is how the malaria parasite is regulated in the liver. Some conventional immune responses have been shown to be partially effective against the malaria parasite, but some malaria parasites are still able to develop and go on to cause disease and death. Boosting our natural ability to fight the malaria parasite while it is still in the liver could eliminate the symptoms of the disease, and subsequent transmission. In our recent publication, “Liver stage malaria infection is...
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The Hippo pathway is involved in regulating contact inhibition of proliferation and organ size control and responds to various physical and biochemical stimuli. It is a kinase cascade that negatively regulates the activity of cotranscription factors YAP and TAZ, which interact with DNA binding transcription factors including TEAD and activate the expression of target genes. In this study, we show…
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Naturally occurring RNAs are known to exhibit a high degree of modularity, whereby specific structural modules (or motifs) can be mixed and matched to create new molecular architectures. The modular nature of RNA also affords researchers the ability to characterize individual structural elements in controlled synthetic contexts in order to gain new and critical insights into their particular structural features…
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T cell-mediated immune memory provides the host with the capacity to rapidly and efficiently respond to pathogen re-encounter, often without symptoms or disease. In addition to conventional memory T cell responses that are pathogen-specific, there also exist a subset of unconventional memory T cells that share many of the characteristics of conventional memory T cells without the initiating requirement of cognate antigen recognition. Here, we demonstrate a mechanism whereby regulatory T cells limit the...
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Understanding the structure–function relationships between diverse cell types in a complex organ environment requires detailed in situ reconstruction of cell-associated molecular properties in the context of 3D, macro-scale tissue architecture. We recently developed clearing-enhanced 3D (Ce3D), a simple and effective method for tissue clearing that achieves excellent transparency; preserves cell morphology, tissue architecture, and reporter molecule fluorescence; and is robustly…
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Synthetic Bistability and Differentiation in Yeast

Engineered systems that control cellular differentiation and pattern formation are essential for applications like tissue engineering, biomaterial fabrication, and synthetic ecosystems. Synthetic circuits that can take on multiple states have been made to engineer multicellular systems. However, how to use these states to drive interesting cellular behavior remains challenging. Here, we present a cellular differentiation program involving a novel synthetic…
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Read the Publication This week we profile a recent publication in Nature Communications from the laboratory of Dr. Luis Ceze at the University of Washington School of Computer Science and Engineering. Can you provide a brief overview of your lab’s current research focus? Our lab explores the intersection of computing and biotech for new applications. Our current flagship project is…
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Our lab has been instrumental in developing "nanopore sequencing", a technology that can electronically read the sequence of DNA molecules. Nanopore sequencing has several advantages over existing DNA sequencing methods. Nanopore sequencing can directly read long pieces of DNA, while conventional methods must piece the DNA’s sequence together from short fragments of DNA. Nanopore’s long reads enable scientists to understand parts of the genome that cannot be read using other methods. Additionally, nanopore sequencing has the potential to be faster...
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The Greninger lab is interested in genomic and proteomic informed approaches to infectious diseases.  That means we need some viral genomes to understand what we’re dealing with, i.e., diversity, evolution, recombination, etc, before moving on to making sure the genes are in the right place before we can get to more fun functional studies.   For the last 3 years, we’ve focused on HSV-1, HSV-2, HHV-6, and the human parainfluenzaviruses and coronaviruses because these were relatively undersequenced and honestly understudied relative to their burden.  This story is straight out of the genomic surveillance of HSV-1 and HSV-2...
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Cell-autonomous Wnt signaling has well-characterized functions in controlling stem cell activity, including in the prostate. While niche cells secrete Wnt ligands, the effects of Wnt signaling in niche cells per se are less understood. Here, we show that stromal cells in the proximal prostatic duct near the urethra, a mouse prostate stem cell niche, not only produce multiple Wnt ligands but also exhibit…
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