Noncoding variants are critical to our understanding of the genetic basis of diseases and disorders…
karnottApril 8, 2026
A Common 19 BP APOE Enhancer Deletion Is Protective Against Alzheimer’s Disease in African Americans
The APOE-ε4/ε4 genotype is the strongest genetic risk factor for sporadic Alzheimer’s disease, though the…
Enhancing regulatory T cell (Treg) function offers a compelling therapeutic strategy for autoimmune disease. Engineered…
karnottMarch 25, 2026
The interactions between lytic phages and their hosts are typically studied in bulk culture, which…
karnottMarch 23, 2026
Nanoparticle drug delivery systems have significant potential to transform precision medicine due to their ability…
karnottMarch 9, 2026
Identity-by-descent (IBD) mapping provides complementary signals to genome-wide association studies (GWASs) when multiple causal haplotypes…
karnottMarch 6, 2026
The androgen receptor (AR) is a critical driver of prostate cancer (PCa). Here, to study…
karnottFebruary 25, 2026
Effective antitumor immunity ultimately depends on the priming and activation of tumor-specific cytotoxic CD8+ T…
karnottFebruary 17, 2026
Epistatic interactions present a major challenge in accurate genotype–phenotype correlation. Here, we combined high-throughput yeast…
karnottFebruary 11, 2026
RNA-driven protein aggregation leads to cellular dysregulation and contributes to the development of diseases and…
karnottFebruary 2, 2026
