Publications of the Week Alveolar Macrophages Provide an Early Mycobacterium tuberculosis Niche and Initiate Dissemination Cohen, S.B., et al. | September 14, 2018 Mycobacterium tuberculosis (Mtb) infection is initiated in the distal airways, but the bacteria ultimately disseminate to…sciencecitySeptember 14, 2018 Read More
Publications of the Week Human T Cell Receptor Occurrence Patterns Encode Immune History, Genetic Background, and Receptor Specificity DeWitt, W.S., et al. | September 10, 2018 High-throughput DNA sequencing has enabled deep profiling of the set of receptors that T and…sciencecitySeptember 10, 2018 Read More
Publications of the Week Cas9 Immunity Creates Challenges for CRISPR Gene Editing Therapies Crudele, J.M., et al. | September 5, 2018 Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 is a genome-editing technology1,2 that utilizes archaeal and bacterial…sciencecitySeptember 5, 2018 Read More
Publications of the Week Early Cellular Innate Immune Responses Drive Zika Viral Persistence and Tissue Tropism in Pigtail Macaques O'Connor, M.A., et al. | September 3, 2018 The immunological and virological events that contribute to the establishment of Zika virus (ZIKV) infection…sciencecitySeptember 3, 2018 Read More
Publications of the Week An Assay for De Novo Kinetochore Assembly Reveals a Key Role for the CENP-T Pathway in Budding Yeast Lang, J., et al. | August 31, 2018 Chromosome segregation depends on the kinetochore, the machine that establishes force-bearing attachments between DNA and…sciencecityAugust 31, 2018 Read More
Publications of the Week Viral Genetic Diversity and Protective Efficacy of a Tetravalent Dengue Vaccine in Two Phase 3 Trials Juraska, M., et al. | August 29, 2018 Two phase 3 placebo-controlled trials of the CYD-TDV vaccine, evaluated in children aged 2-14 y…sciencecityAugust 29, 2018 Read More
Publications of the Week Deep Mutational Scanning of Hemagglutinin Helps Predict Evolutionary Fates of Human H3N2 Influenza Variants Lee, J.M., et al. | August 24, 2018 Human influenza virus rapidly accumulates mutations in its major surface protein hemagglutinin (HA). The evolutionary…sciencecityAugust 24, 2018 Read More
Publications of the Week Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module Hsu, P.L., et al. | August 22, 2018 The SET1/MLL family of histone methyltransferases is conserved in eukaryotes and regulates transcription by catalyzing…sciencecityAugust 22, 2018 Read More
Publications of the Week Single-Molecule Analysis of a Viral Fusion Protein Illuminates a Fusion-Active Intermediate State Benhaim, M. and Lee, K.K. | August 20, 2018 The influenza virus hemagglutinin (HA) fusion glycoprotein mediates viral entry into host cells through its…sciencecityAugust 20, 2018 Read More
Publications of the Week B Cell Adaptor for PI3-Kinase (BCAP) Modulates CD8+ Effector and Memory T Cell Differentiation Singh, M.D., et al. | August 17, 2018 CD8+ T cells respond to signals via the T cell receptor (TCR), costimulatory molecules, and immunoregulatory…sciencecityAugust 17, 2018 Read More