Benaroya Research Institute

Benaroya Research Institute at Virginia Mason (BRI) is an internationally-recognized non-profit medical research institute affiliated with the Virginia Mason Health System.

BRI works to advance the science that will predict, prevent, reverse and cure diseases of the immune system, to achieve its vision of a healthy immune system for every individual. Our scientific approach is to discover, translate, integrate and intervene – accelerating translation of today’s lab discoveries into tomorrow’s clinical interventions.  The institute’s core values of persistent inquiry; innovation and agility; collaboration; and integrity and respect are foundational to our work.

A leader of collaborative initiatives such as the Immune Tolerance Network and Type 1 Diabetes TrialNet, BRI frequently partners with global research institutes, pharmaceutical and biotech companies to translate discoveries into clinical therapies.

Visit or follow BRI’s Autoimmune Life Blog, Facebook, Instagram, LinkedIn or Twitter to learn more.

Position #: 2020-1650
Title: Staff Scientist
Department: Long Lab

Status: Full time


The Long Lab is a translational immunology lab focused on better understanding underlying mechanisms of autoimmune disease, patient variability, and response to therapy.  Currently, we are primarily focused on three, inter-related projects in the setting of T1D: 1) Causes and consequences of reduced response to IL-2, 2) Cellular definition and stability of CD8 T cell exhaustion associated with response to therapy, and 3) identification of biomarkers of disease severity.

Each of these projects use human samples, are collaborative in context working with the diabetes team, genomics and systems immunology, and use the resources of the BRI Human Immunophenotyping (HIP) Core, supervised by Dr. Alice Long.


The Staff Scientist conducts independent biomedical research relevant to defining mechanisms underlying CD8 T cell exhaustion in the context of type 1 diabetes (T1D).

Duties include:

  •  Design and perform experiments and analysis relevant to cellular, molecular and functional definition of CD8 ‘exhausted’ cells found in T1D (Long,, Sci Imm, Wiedeman,, JCI) and molecular mechanisms that underlie stability and function of these cells at different stages of disease
    • Work with the BioInformatics team at BRI to design and perform experiments
    • Integrate data from multiple platforms and collaborative efforts to test hypotheses about the ontogeny, stability and survival of exhausted cells.
  • Collaborate with leaders in the field of autoimmunity
  • Publish papers, write grants and present findings at meetings
  • Supervise support staff in the lab


  • The Staff Scientist is a team-player who welcomes challenges and wants to grow as a translational biologist, bringing their unique perspective to the field.
  • Requires a Ph.D. in Immunology or a related field, at least 3 years post-doctoral experience and experience in tissue culture, cellular and molecular techniques.
  • Prefer experience with cytometry and large data-sets.

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All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, disability or protected veteran status.



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