Researchers at German institutions that have let their Elsevier subscriptions lapse while negotiating a new deal are hitting the paywall for the publisher’s most recent articles around 10,000 times a day, according to Elsevier — which publishes more than 400,000 papers each year. But at least some German libraries involved in negotiating access to Elsevier say they are making huge…
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Sustainable Squalene Replacement Needed for Pharma

IDRI (Infectious Disease Research Institute) is pleased to announce a $4.4 million, five-year grant from the National Institute of Allergy and Infectious Diseases (part of the U.S. National Institutes of Health) to discover sustainable alternatives  to shark squalene to use as vaccine adjuvants (grant number: R01AI135673). Funding is provided by a special bioengineering research grant aimed at bringing  engineering expertise to…
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Computer components designed to recognize images behave surprisingly like neurons in the brain, researchers at the University of Washington School of Medicine report. “We found that deep neural networks used for recognizing images actually have single units within them that respond in remarkably similar ways as do neurons within the visual system of the brain,” said lead author Dean A…
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More than two-thirds of people with an advanced form of a rare skin cancer are on track to survive at least two years after starting an immunotherapy drug on a landmark clinical trial, researchers reported Wednesday in the Journal of Clinical Oncology. That’s a profound shift for this deadly cancer, Merkel cell carcinoma, or MCC. Just a few years ago, patients with…
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Merkel cell polyomavirus (MCPyV) accounts for 80% of all Merkel cell carcinoma (MCC) cases through expression of two viral oncoproteins: the truncated large T antigen (LT-t) and small T antigen (ST). MCPyV ST is thought to be the main driver of cellular transformation and has also been shown to increase LT protein levels through the activity of its Large-T Stabilization…
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Q&A: A New Focus on Small Cell Lung Cancer

About 15 percent of lung tumors are small cell lung cancer. Treatment for this aggressive and deadly malignancy has remained nearly unchanged for decades. Recently, however, immunotherapy drugs have modestly extended patient survival. But researchers are trying to do more. Fred Hutchinson Cancer Research Center small cell lung cancer expert Dr. David MacPherson is working to understand the biology of the disease…
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ISCRM Labs Collaborate to Grow Heart Tissue In Vitro

Heart failure is the leading cause of death in the world. In the United States alone, hundreds of thousands of people succumb to the disease every year, while the costs of care and lost productivity drain more than $200 billion from the economy. Recent breakthroughs in stem cell research offer hope for new treatments that could help patients regrow muscle…
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Benjamin “Beno” Freedman has been named STEM CELLS’ Young Investigator of 2018 for his groundbreaking work with organoids in studying kidney structure and disease. The award was created to foster advancements in the fields of stem cells and regenerative medicine by honoring a young researcher who is principal author of a STEM CELLS paper that is deemed to have the most impact…
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Aided by Stem Cells, ISCRM Researchers Identify a Suspect in the Case of Infertility

Of all the mysteries surrounding the beginning of human life, one question has drawn particular interest from researchers at the Institute for Stem Cell and Regenerative Medicine (ISCRM). Simply put, for women who are unable to get pregnant, what is happening at the cellular level that is preventing life from taking hold? Finding an answer may bring joy to millions…
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Viewing images of diseased cells on a computer screen means limited detail and restricted angles, prohibiting researchers from fully analyzing specimens. So researchers from Benaroya Research Institute at Virginia Mason (BRI)—a Seattle-based research organization—are taking a different approach. For more than a year, BRI researchers have used virtual reality (VR) tools to conduct detailed experiments about autoimmune and immune system…
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