The National Institutes of Health has awarded a $6.5 million, five-year grant to the University of Washington and partner institutions to establish the Center for Reproducible Biomedical Modeling. The center’s primary goal is to develop more effective predictive models of biological systems, which are used in research and medicine. “We are delighted that the NIH has made this award,” said Herbert Sauro,…
Seattle Children’s Research Institute is launching a clinical trial that will examine a new kind of cancer-fighting treatment. The treatment is a type of CAR T immunotherapy, which reprograms a person’s immune cells to find and destroy cancer. CAR T therapies have found early success in blood cancers, including leukemia and lymphoma, but have run into obstacles when it comes…
Syphilis research has been severely limited by the necessity to propagate Treponema pallidumin vivo in rabbits. After decades of erroneous or irreproducible reports of cultivation of T. pallidum, the recent very convincing report of its successful long-term in vitro propagation opens numerous opportunities for development of genetictools for studying pathogenesis and protein function, antigenic variation, and surface exposure of antigens. The possibility of more rapid isolation of…
Scientists have completed a major effort to map the regulatory landscape of the mouse genome at a single-cell resolution. The team applied a special assay that they had previously developed to profile a genomic feature called chromatin accessibility. The researchers were interested in how the DNA winding, wrapping and packaging into what is termed chromatin influences what genetic information is…
More than a dozen area tech and biotech companies are supporting Fred Hutch Obliteride this year to help accelerate the lifesaving work at Fred Hutchinson Cancer Research Center. Amazon, Microsoft, Seattle Genetics, Juno, Blue Nile and Lyft are a few of the companies helping sponsor the event and have rallied large teams of employees to participate and fundraise. Other companies including Adaptive Technologies,…
The Damon Runyon Cancer Research Foundation has named Fred Hutchinson Cancer Research Center’s Dr. Jay F. Sarthy as one of five outstanding young scientists to receive the prestigious Damon Runyon-Sohn Pediatric Cancer Fellowship Award. He will receive $231,000 over four years to study pediatric brain cancers. Under the mentorship of geneticist Dr. Steven Henikoff and pediatric neuro-oncologist Dr. Jim Olson of the Hutch, Sarthy will aim…
In this study, we tested whether iodide would reduce heart damage in rat and pig models of acute myocardial infarction as a risk analysis for a human trial. Acute myocardial infarction was induced by temporary ligation of the coronary artery followed by reperfusion. Iodide was administered orally in rats or IV in rats and pigs just prior to reperfusion. Damage was assessed by blood…
Five years ago, IDRI (Infectious Disease Research Institute) moved into a state-of-the-art lab at 1616 Eastlake Avenue East, which is owned and operated by Alexandria Real Estate Equities, Inc. (NYSE: ARE), in the heart of Seattle’s growing South Lake Union life sciences hub. Today, the IDRI-Alexandria partnership continues as IDRI is hosts a summer intern from the University of Washington’s…
Grab your litter scoopers, folks — there might just be valuable scientific data in your cat’s poop. That was certainly the case for Lil Bub, one of the original internet cat celebrities. These days, Bub is using her fame to further a huge host of causes, including learning more about the bacteria floating around inside animal’s digestive systems. Phase Genomics, a Seattle-based…
Dr. Stanley Gartler was born on June 9, 1923, in Los Angeles, California to Romanian immigrant parents. During WWII, he flew combat with the 9th Air Force as a radio operator and machine gunner. Having an early interest in agriculture, Gartler worked on a farm after earning his undergraduate degree at UCLA and studied genetic plant breeding in graduate school…
