CD4+ T helper (Th) cells play a central role in orchestrating protective immunity but also in autoimmunity. Multiple Sclerosis (MS) is a human autoimmune disease of the central nervous system (CNS) characterized by the infiltration of inflammatory lymphocytes and myeloid cells into the brain and spinal cord, leading to demyelination, axonal damage, and progressive loss of motor functions. The release of…
Read More

Standard Myeloma Treatment Reveals Itself as an Immunotherapy

New research suggests that doctors may have had an incorrect understanding of how a standard treatment for an incurable blood cancer works to prolong lives. The therapy, based around high doses of chemotherapy or radiation, looks like it may actually be an immunotherapy — that is, a treatment that stimulates the patients’ own immune systems to help fight their cancers.…
Read More
UW Medicine researchers are exploring a potential new approach to treating the common childhood cancer acute lymphocyte  leukemia, or ALL. ALL, a blood cancer, represents approximately 25 percent of cancer diagnoses in the newborn to 15-year-old age range. More than 3,000 new cases of ALL are diagnosed every year in the United States, and the incidence is rising. Matt Hart, a postdoc  in…
Read More
Each morning, 8-year-old Erin Cross springs out of bed excited to go to school. A third grader in Chester, England, she loves science and math, and imagines a future as a researcher making “potions” in a lab. She loves cracking jokes, rugby and playing make-believe games with her friends on the playground. For Erin, who spent most of her life…
Read More

Major NIH-CASIS Grant for Team Led by Dr. Deok-Ho Kim

An interdisciplinary team led by ISCRM Faculty Member Deok-Ho Kim has been awarded a new NIH-CASIS Tissue Chips in Space UG3/UH3 grant to support research that aims to improve our understanding of how extended periods in microgravity affect the functional capacity of human myocardial tissue and that could have significant impact on the development of deep space missions in the…
Read More
Bacteria causing chronic infections are generally observed living in cell aggregates suspended in polymer-rich host secretions, and bacterial phenotypes induced by aggregated growth may be key factors in chronic infection pathogenesis. Bacterial aggregation is commonly thought of as a consequence of biofilm formation; however the mechanisms producing aggregation in vivo remain unclear. Here we show that polymers that are abundant…
Read More
ResearchGate, a popular networking platform where scientists can post their published work, has a complicated relationship with academic publishers. A number of them have accused the site of illicitly disseminating copyrighted work, and two of these—Elsevier and the American Chemical Society—filed a lawsuit in Germany last year to try to force ResearchGate to change its practices. The pair has now escalated the…
Read More
UW Medicine and Seattle Children’s announced Oct. 9 that Dr. Leslie R. Walker-Harding has been named chair of the UW School of Medicine Department of Pediatrics, associate dean for the UW School of Medicine and senior vice president/chief academic officer for Seattle Children’s. Walker-Harding will assume her new position on Feb. 15, 2019. Walker-Harding is currently a professor and chair…
Read More
Diabetes is a major public health concern that increases the risk of cardiovascular disease and is a leading cause of blindness, amputation and kidney failure.  The mission of the Morton laboratory is to understand the role of the brain in the control of blood sugars and determine how defects in this system contribute to insulin resistance and diabetes.  Specifically, our laboratory, in collaboration with Dr. Michael Schwartz at the University of Washington (UW), examines how the brain senses and responds to...
Read More
Seattle researchers are addressing government concerns about viral outbreaks in the United States through the development of the flu patch. This unique method of delivering vaccinations makes healthcare more accessible to Americans and potentially people around the world. The Infectious Disease Research Institute (IDRI), a Seattle-based nonprofit that produces diagnostic tools and vaccines to solve global health challenges, was approached…
Read More