Publications of the Week The Landscape of Alternative Polyadenylation in Single Cells of the Developing Mouse Embryo Agarwal, V., et al. | August 27, 2021 3′ untranslated regions (3′ UTRs) post-transcriptionally regulate mRNA stability, localization, and translation rate. While 3′-UTR…dcorriganAugust 27, 2021 Read More
Publications of the Week A Therapeutic Cancer Vaccine Delivers Antigens and Adjuvants to Lymphoid Tissues Using Genetically Modified T Cells Veatch, J.R., et al. | August 26, 2021 The authors showed that Tvax works by delivering antigens to lymphoid organs throughout the body…dcorriganAugust 26, 2021 Read More
Local News Seattle Biotech Firm Shape Therapeutics Inks Gene Therapy Deal with Roche Worth Up to $3B GeekWire | August 25, 2021 Shape Therapeutics has signed a deal potentially exceeding $3 billion with pharma giant Roche to support…dcorriganAugust 25, 2021 Read More
Local News Biotech Companies Fuel IPO Boom in Washington State over the Past Year GeekWire | August 24, 2021 In a region better known for its tech startups and legions of software engineers, it’s…dcorriganAugust 24, 2021 Read More
Local News New Computational Method Opens Window into Immune Cell Behavior Fred Hutch | August 24, 2021 Immune cells have many jobs to do: Some identify infected cells and eliminate them. Others…dcorriganAugust 24, 2021 Read More
Publications of the Week Endomembrane Targeting of Human OAS1 p46 Augments Antiviral Activity Soveg, F., et al. | August 23, 2021 Lead authors Frank Soveg and Johannes Schwerk identified a membrane-targeted gene, OAS1 p46, with strong…dcorriganAugust 23, 2021 Read More
Publications of the Week The Redox-Responsive Transcriptional Regulator Rex Represses Fermentative Metabolism and Is Required for Listeria monocytogenes Pathogenesis Halsey, C., et al. | August 20, 2021 In this work, we characterized the role of the redox-responsive transcriptional regulator Rex in Listeria…dcorriganAugust 20, 2021 Read More
Publications of the Week Massively Parallel Characterization of CYP2C9 Variant Enzyme Activity and Abundance Amorosi, C., et al. | August 20, 2021 Scientists only have accurate dosage advice for a small number of the most well-studied genetic…dcorriganAugust 20, 2021 Read More
Publications of the Week A Subpopulation of Microglia Generated in the Adult Mouse Brain Originate from Prominin-1 Expressing Progenitors Prater, K., et. al | August 19, 2021 Microglia maintain brain health and play important roles in disease and injury. Despite their known…dcorriganAugust 19, 2021 Read More
Local News Aptevo Therapeutics Announces APVO436 Monotherapy Is Active in Patients Who Have Relapsed Acute Myeloid Leukemia or Myelodysplastic Syndrome Aptevo Therapeutics | August 18, 2021 Aptevo Therapeutics Inc., a clinical-stage biotechnology company focused on developing novel immuno-oncology therapeutics based on…dcorriganAugust 18, 2021 Read More