For children battling through a diagnosis of relapsed leukemia, moving away from standard chemotherapy and onto newer, safer treatments is something many families are hopeful for. Seattle Children’s is actively working to identify, validate and innovate how children with pediatric acute leukemia, including acute myeloid leukemia and other high-risk leukemias, are treated through a collaborative master screening clinical trial led…
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Seattle-based Precision Oncology company SEngine Precision Medicine has now raised a total of $19M, following the recent closing of a $10M Series A2, as it continues to commercialize a platform that matches cancer patients to the right drug and also drives drug discovery. The Series A2 round was led by the Washington Research Foundation along with Alethea Fulcrum Fund, Vincere…
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More than 2 years in the making, a massive bill that Congress completed this week aims high: It envisions a 5-year, $280 billion investment to keep the United States ahead of China in a global competition for technological preeminence. The CHIPS and Science Act, passed yesterday by the House of Representatives and on Wednesday by the Senate, will result in…
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A new study shows how mutation of the ADAR1 gene sets off biochemical pathways that produce an autoimmune response that harms the developing brain and other areas of the body. The ADAR gene contains instructions for making proteins used by the immune system. Normally, the body’s immune system fights off pathogens, foreign bodies, and cancers. An RNA-editing enzyme produced by…
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Translational breast cancer researcher Dr. Cyrus Ghajar, epidemiologist Dr. Christopher Li, and immunotherapy expert Dr. Stanley Riddell of Fred Hutchinson Cancer Center have received a four-year, $25 million grant from the U.S. Department of Defense to learn how to kill metastatic cancer’s deadly seeds before they can sprout. The new Transformative Breast Cancer Consortium Award, specifically designed to fund high-risk/high-reward…
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Read the Publication This week we profile a recent publication in Blood Advances from the laboratory of Dr. Carol Miao (pictured, front row, left) at UW, Seattle Children’s, and Fred Hutch. Can you provide a brief overview of your lab’s current research focus? My lab focuses on investigating potentially clinically translatable approaches for hemophilia treatment. The goal is to develop…
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Pancreatic ductal adenocarcinoma (PDAC) typically presents as metastatic disease at diagnosis and remains refractory to treatment. Next generation sequencing efforts have described the genomic landscape, classified molecular subtypes, and confirmed frequent alterations in major driver genes, with coexistent alterations in KRAS and TP53 correlating with the highest metastatic burden and poorest outcomes. However, translating this information to guide therapy remains…
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The news: Single cell analysis startup Ozette Technologies, with deep roots in the Seattle academic and startup community, has raised $26 million. The company’s tools enable its academic and biopharma partners to pinpoint and quantify immune cell types from massive datasets. The tools support clinical trials and other research. The background: Ozette spun out of Fred Hutchinson Cancer Center in…
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Alzheimer’s disease wreaks unmistakable havoc in the brain. If you compare the brain of someone who has died from neurodegenerative disease to that of a healthy person, you can’t miss the difference: In the case of severe Alzheimer’s, the brain will be noticeably smaller, with large gaps where pieces would normally nestle close together. This shrinkage, termed brain atrophy, is…
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Curi Bio, a leading developer of human stem cell-based platforms for drug discovery, announced the commercial launch of the Mantarray™ platform for human-relevant 3D heart and skeletal engineered muscle tissue (EMT) contractility analysis. Curi’s Mantarray platform enables the discovery of new therapeutics by providing parallel analysis of 3D EMTs with adult human-like functional profiles of healthy and disease models. Over…
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