Why COVID-19 Makes It Harder To Predict This Year’s Flu Season

Before COVID-19, having the sniffles or a mild headache was rarely cause for concern. Now, it’s common practice to stay home at the first sign of a cold. This is one of the reasons that there was very low flu activity during last year’s flu season. But will that trend continue this year? “We saw very little influenza activity last year,…
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Deep Learning Reveals How Proteins Interact

A team led by scientsts in the Baker lab has combined recent advances in evolutionary analysis and deep learning to build three-dimensional models of how most proteins in eukaryotes interact. This breakthrough has significant implications for understanding the biochemical processes that are common to all animals, plants, and fungi. This open-access work appears in Science. Proteins are the workhorses of all…
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Kate Drabinski was hardly a stranger to breast cancer. Two of her aunts and her mother had all gone through it. Still, “nobody ever suggested genetic testing,” said the 46-year-old gender and women’s studies teacher from Baltimore, Maryland. Her primary care doctor did suggest regular mammograms, though, so she began getting them at age 37. Five years later, when she was diagnosed…
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SK bioscience (CEO Jae-yong Ahn) announced on November 4th that the company has confirmed a positive immune response and safety in the final analysis result of the phase I/II clinical trial of the COVID-19 vaccine candidate, ‘GBP510,’ co-developed with the Institute for Protein Design at the University of Washington in the U.S and adjuvanted with GlaxoSmithKline’s (GSK) pandemic adjuvant system. SK…
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A molecular study published today in Science reveals how the mutations in delta and kappa variants of the pandemic coronavirus help the variants avoid recognition by antibodies. Most vaccine developers have concentrated on targeting the spike glycoprotein on the surface of the pandemic coronavirus. The spike glycoprotein comprises an N-terminal domain, that enhances cell binding, and a receptor binding domain that engages with…
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Dendritic and axonal morphology reflects the input and output of neurons and is a defining feature of neuronal types1,2, yet our knowledge of its diversity remains limited. Here, to systematically examine complete single-neuron morphologies on a brain-wide scale, we established a pipeline encompassing sparse labelling, whole-brain imaging, reconstruction, registration and analysis. We fully reconstructed 1,741 neurons from cortex, claustrum, thalamus,…
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Undergraduate Students on the Hunt for Cancer Killing Molecules

Years ago, a postdoc in the Ruohola-Baker Lab wrote a paper describing a biological mechanism in fruit flies that protects stem cells from apoptosis – in other words, that prevents cell death. The author suggested a systematic drug screen for molecules that might subvert this protective mechanism and induce cell death. Such a drug would be a powerful tool in the fight against cancer. Scientists have…
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Inventprise, a biotechnology company specializing in novel, affordable and highly impactful vaccines, announced today that the Bill & Melinda Gates Foundation, a global non-profit organization, has made a program-related investment in the company’s continued development of IVT-25, an investigational pneumococcal conjugate vaccine designed to prevent pneumococcal bacterial infections. Pneumonia remains the single largest infectious cause of death in children worldwide.…
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Leukemias from both an adult and a child may look the same under a microscope. They may have the same name. But take a deeper look at the molecular engines that make them go, and it becomes clear that they’re completely different diseases. Understanding those distinctions, knows Dr. Soheil Meshinchi, is absolutely critical to giving patients the right treatment. The Fred Hutchinson…
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The Allen Institute today announced six new Next Generation Leaders, members of a unique neuroscience advisory panel made up of early-career researchers. Now in its eighth year, the Next Generation Leaders Council advises neuroscience research efforts at the Allen Institute: the Allen Institute for Brain Science, the MindScope Program, and the newly launched Allen Institute for Neural Dynamics. Next Generation…
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