The study of a protein, critical in causing asthma, allergies and other diseases, has led scientists at Benaroya Research Institute at Virginia Mason (BRI) to discover a new strategy for stopping breast cancer. BRI researchers Emma Kuan, PhD, and Steven Ziegler, PhD, have pinpointed how the protein, called thymic stromal lymphopoietin (TSLP), helps breast cancer tumors survive and grow. Even more significant,…
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The measles outbreak has U.S. Surgeon General Jerome M. Adams, M.D., M.P.H., visiting Washington state to get a better understanding of the problem here. “I appreciate what you do each and every day,” Adams said to staff at Seattle’s Odessa Brown Children’s Clinic on Thursday. outbreak. “Did you gain any insight on what’s causing so many parents there to opt out?” KIRO7’s Deedee…
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In rodent models of type 2 diabetes (T2D), sustained remission of diabetic hyperglycemia can be induced by a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1). To identify the brain area(s) responsible for this effect, we first used immunohistochemistry to map the hypothalamic distribution of phosphoERK (pERK1/2), a marker of MAP kinase-ERK signal transduction downstream of FGF receptor…
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Aga Khan University and Fred Hutch Join in Global Collaboration

The Aga Khan University and Fred Hutchinson Cancer Research Center this week expressed their shared commitment in working together to improve the prevention, diagnosis and treatment of cancer and related diseases in low- and middle-income countries. President Firoz Rasul of Aga Khan University and President and Director of Fred Hutch, Dr. Gary Gilliland, signed a memorandum of understanding which aims to foster joint international scientific…
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A first-of-its-kind nanoparticle vaccine candidate for respiratory syncytial virus has been designed in an international research effort. RSV is second only to malaria as a cause of infant mortality worldwide. The new vaccine elicits potent neutralizing antibodies against RSV in both mice and monkeys. The animal research findings, reported March 7 in the journal Cell, pave the way for human clinical trials.…
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Have you ever jumped in fear, and then a split second later realized that a spider (or a spider-shaped shadow) was at the edge of your vision? Your brain enables different kinds of responses to visual information. There’s the conscious response to what you see, which is what allows you to read and understand words, check the weather through a…
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Dr. Adam Dingens, a postdoctoral HIV researcher at Fred Hutchinson Cancer Research Center, is among 13 recipients of the institution’s 2019 Harold M. Weintraub Graduate Student Award, which recognizes outstanding achievement in graduate studies in the biological sciences. Nominations for this prestigious award are solicited internationally. This year’s 13 awardees come from academic institutions around the United States, including Johns Hopkins…
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Avoidance of innate threats is often in conflict with motivations to engage in exploratory approach behavior. The neural pathways that mediate this approach-avoidance conflict are not well resolved. Here we isolated a population of dopamine D1 receptor (D1R)-expressing neurons within the posteroventral region of the medial amygdala (MeApv) in mice that are activated either during approach or during avoidance of…
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Can an emotion shorten your lifespan? Absolutely, says former U.S. surgeon general Dr. Vivek Murthy. Something that millions of us feel every single day has now become a pervasive medical condition, and it’s linked to arthritis, diabetes, dementia and heart disease. We’re talking about loneliness, a condition that makes you 50 percent more likely to die prematurely. Murthy warns that…
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Metagenomic sequencing is a promising approach for identifying and characterizing organisms and their functional characteristics in complex, polymicrobial infections, such as airway infections in people with cystic fibrosis. These analyses are often hampered, however, by overwhelming quantities of human DNA, yielding only a small proportion of microbial reads for analysis. In addition, many abundant microbes in respiratory samples can produce large…
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