ISB Marking 20th Anniversary with Year-Long Celebration

In 2000, Drs. Lee Hood, Ruedi Aebersold and Alan Aderem created ISB as the first-ever institute dedicated to systems biology. For the past two decades, our scientists have been on the ground floor on many important research areas — aging and wellness, computational biology, brain diseases, and many chronic and infectious diseases, to name a few. Furthermore, ISB has improved…
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The University of Washington recently launched a science technology master’s degree that has quickly gained traction with undergraduates looking to get careers in research and technology. Though the application deadline is still more than a month out, the University of Washington’s continuing education and professional development branch Continuum College has offered 22 students a slot in its master of science in applied…
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The holiday season is upon us, and as research begins to slow towards the end of the year, we too will be taking a short break to prepare for the new year ahead. The Science in Seattle website will be dark for the remainder of the holiday season, but will return as your source for local life science news on…
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U.S. scientists who violate government rules on disclosing foreign research ties should be investigated for research misconduct, says an independent group of prominent scientists asked to examine the threat of foreign influences on the U.S. research enterprise. Although the report concludes that the threat is real, it says the government should not impose new restrictions on the pursuit of basic research in…
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Dr. Raphael Gottardo is the scientific director at the Fred Hutchinson Cancer Research Center, an organisation which looks for new ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Dr. Gottardo has a PhD in statistics, focusing on the overlap between biology, statistics and computational skills. This has put him in good stead for his role at…
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In the wake of recent disappointments over clinical trials targeting amyloid plaque build-up in Alzheimer’s disease, researchers are focusing more attention on misfolded tau protein, another culprit in brain diseases that cause dementia. New research published in Science Translational Medicine finds that targeting abnormal tau through the suppression of a gene called MSUT2 (mammalian suppressor of tauopathy 2) shows promise. Tau, like amyloid protein, is…
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The authors evaluated the effects of four specific antibiotics in healthy female rhesus macaques. All antibiotics disrupted the microbiome, including reduced abundances of fermentative bacteria and increased abundances of potentially pathogenic bacteria. This study demonstrates the importance of considering the necessity of antibiotic use for each occasion.
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Research is beginning at Virginia Mason that will assess the accuracy of a breath test for detecting esophageal cancer, one of the fastest growing and deadliest cancers in the United States. The project, supported by a grant from the Salgi Esophageal Cancer Research Foundation, is led by Donald Low, MD, who specializes in esophageal and thoracic surgery, along with George Hanna, PhD, of St.…
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Immunotherapy with the adoptive transfer of T cells redirected with CD19-specific chimeric antigen receptors (CARs) for B-lineage acute lymphoblastic leukemia (ALL) can salvage >80% of patients having relapsed/refractory disease. The therapeutic index of this emerging modality is attenuated by the occurrence of immunologic toxicity syndromes that occur upon CAR T-cell engraftment. Here, we report on the low incidence of severe…
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A new survey of the activity of nearly 60,000 neurons in the mouse visual system reveals how far we have to go to understand how the brain computes. Published today in the international journal Nature Neuroscience, the analysis led by researchers at the Allen Institute reveals that more than 90% of neurons in the visual cortex, the part of the brain that…
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