Seattle vaccine startup Curevo, which is developing a vaccine against shingles, raised $26 million. The funding comes on the heels of $60 million raised in February to advance the company’s clinical trial for its shot against shingles, a painful condition caused by reactivation of the virus that causes chicken pox. The startup aims to develop a shingles vaccine with a better safety profile…
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Fred Hutchinson Cancer Center cell biologist Susan Parkhurst, PhD, was named the second Mark Groudine Endowed Chair for Outstanding Achievements in Science and Service. Established by an anonymous donor in 2016, the chair recognizes the scientific achievements and administrative contributions to Fred Hutch of both Parkhurst and Mark Groudine, MD, PhD. Parkhurst studies the cytoskeleton, the internal meshwork that helps regulate cell shape…
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This year 37 UW School of Medicine faculty members and scientists affiliated with UW Medicine have been named to the Clarivate Highly Cited Researchers™ list. The list was released today, Nov. 15. Both quantitative and qualitative methods are used to identify individuals from across the globe who have demonstrated significant and broad influence in their chosen area of research. The preliminary list of Highly…
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BBI Scientific Director Dr. Jay Shendure acknowledged ‘incredible support of CoMotion and UW Medicine, as well as my department, the Brotman Baty Institute, and my colleagues.’ Photo courtesy Matt Hagen Several dozen friends, family members, and supporters attended an event September 13 honoring BBI’s Scientific Director Dr. Jay Shendure, who was named “Inventor of the Year” by UW Medicine and UW’s…
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Methods for acquiring spatially resolved omics data from complex tissues use barcoded DNA arrays of low- to sub-micrometer features to achieve single-cell resolution. However, fabricating such arrays (randomly assembled beads, DNA nanoballs, or clusters) requires sequencing barcodes in each array, limiting cost-effectiveness and throughput. Here, we describe a vastly scalable stamping method to fabricate polony gels, arrays of ∼1-micrometer clonal…
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A recent study examined how markers of inflammation and angiogenesis in patients with pulmonary arterial hypertension were related to clinical outcomes across disease subtypes. This was a translational retrospective study that explored how cytokine levels were associated with mortality, and how the strength of those connections depended on specific disease subtypes. Patients with connective tissue disease-associated pulmonary hypertension generally had an…
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Seattle biotech giant Seagen has appointed a new CEO, David Epstein, a former executive at Novartis. Epstein also joined the company’s board of directors. Epstein take the helm of the company six months after Seagen co-founder and longtime CEO Clay Siegall resigned from the role in the wake of allegations of domestic abuse and an incident at his home where he was arrested. Siegall, who…
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If an epilepsy patient needs brain surgery, their brain surgeon often extracts a piece of tissue the size of a sugar cube from the outermost layer to access the regions responsible for the seizures. This excised lump is typically discarded as medical waste since it is far from the diseased site. But to neuroscientists like Jonathan Ting, Ph.D., this brain nugget…
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A new study shows that when an experimental cancer medication is split in half, the molecule becomes safer and more effective. Scientists at the University of Washington School of Medicine were looking for ways to improve a promising cancer drug called Neo-2/15. This protein was created to mimic the function of Interleukin-2, or IL-2, which is a natural molecule that can…
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Scientists for the first time have used CRISPR to substitute a gene to treat patients with cancer. The remarkable findings were published in the journal Nature and presented at the Society for Immunotherapy of Cancer (SITC) 2022. Cancer treatments, while targeted at cancer cells, can often also impact healthy tissues and lead to serious side effects. The reported approach first identifies T cells…
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