BBI’s Dr. Danny Miller and the UW’s Nanopore Sequencing Core are providing both targeted and whole genome long read sequencing on the Oxford Nanopore platform to assist other researchers with their projects. “As new DNA and RNA sequencing technologies are developed that provide a more comprehensive view of genetic variation, it is imperative that researchers and clinicians have access to…
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Progress against Peanut Allergies

One question inspired Erik Wambre, PhD, to dedicate his career to allergy research. “Why can most people eat peanuts without a problem, but some people have a serious reaction to just a small amount?” he says. “What makes one person allergic and not another?” Dr. Wambre’s research focuses on what causes allergies and how to stop them — including a…
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Read the Publication This week we profile a recent publication in Leukemia from Dr. George Laszlo (pictured, left) and the laboratory of Dr. Roland Walter (right) at Fred Hutch. Can you provide a brief overview of your lab’s current research focus? Our translational research is focused on acute myeloid leukemia (AML). We are particularly interested in improving antibody-based therapies, both…
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amfAR, The Foundation for AIDS Research, has awarded more than half a million dollars in funding across four research projects pursuing inventive approaches to the treatment and cure of HIV. “These grants and fellowships reflect the vibrancy of HIV research and the wide range of innovative strategies being pursued to end the epidemic,” amfAR’s Chief Executive Officer Kevin Robert Frost…
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The Washington Entrepreneurial Research Evaluation and Commercialization Hub (WE-REACH) is pleased to announce a product concept award for Dr. Anindya Roy and his team at the UW Medicine Institute for Protein Design, including Drs. Jake Kraft and Hua Bai. They are developing a novel binder protein in an aerosolized delivery system to treat idiopathic pulmonary fibrosis (IPF). IPF is a…
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Among the newly elected members of the American Academy of Arts & Sciences are four researchers from the UW School of Medicine and the Fred Hutchinson Cancer Center. They are Caroline “Carrie” Haywood, the Gerald and Lyn Grinstein Professor of Microbiology; and Rachel Klevit, professor of biochemistry and holder of the Edmond H. Fischer/Washington Research Foundation Endowed Chair in Biochemistry, both…
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Umoja Biopharma, Inc., an immuno-oncology company pioneering off-the-shelf, integrated therapeutics that reprogram immune cells in vivo for patients with solid and hematologic malignancies, announced today the Seattle Children’s activation of the Phase 1 ENLIGHTen clinical trial in patients with osteosarcoma to assess the safety and tolerability of autologous “universal” CAR T cells when administered with UB-TT170, the Company’s proprietary small molecule fluorescein…
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Two Fred Hutchinson Cancer Research Center investigators have been elected to the American Academy of Arts and Sciences. Evolutionary biologist Dr. Harmit Malik and molecular biologist Dr. Steven Henikoff were honored for their innovative contributions to our understanding of fundamental biological processes. Malik studies how conflicts between genes with opposing functions shape how genes evolve, while Henikoff focuses on the structure, function and evolution of…
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The Benaroya Research Institute (BRI) announced new research grants, including an $11.4 million-dollar U19 grant to study respiratory viral infections in vulnerable populations and a competitive $3.9M Research Project Grant (R01), both funded by the National Institutes of Health (NIH). All grants awarded to BRI in Q1 2022 totaled more than $17.1 million dollars. The NIH-funded U19 grant program supports…
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The authors show that a commonly occurring type of somatic mutation, loss of heterozygosity (LOH), can be detected at the single-cell level by scRNA-seq. Consequently, in one fell swoop, they show it is possible using scRNA-seq to both identify a cell based on its gene expression signature and infer its lineage based on LOH events shared with other cells. They further show that in females, we can register the branches of the resulting phylogeny to the time in development, around gastrulation, when X-chromosome activation takes place.
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