Blood Cancer Awareness Month in September provides an opportunity to remind the public about the urgent need to support research to find cures, and The Leukemia & Lymphoma Society (LLS) is marking the occasion with a reinvigorated focus on helping children with cancer live better, longer lives. LLS announced today it has more than doubled its funding of research focused…
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If you want a glimpse at medicine’s track record against Alzheimer’s, look no further than the numbers: Pharmaceutical companies have recorded a 99 percent failure rate against the disease, spending billions of dollars on each failed drug candidate. A new effort backed by genomics pioneer Dr. Lee Hood wants to fight Alzheimer’s without developing any drugs at all. Instead, Hood and his collaborators are employing wellness…
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Through the amfAR Research Consortium on HIV Eradication (ARCHE), a grant program that fosters collaboration among teams of scientists, amfAR has awarded new grants totaling $1.16 million to advance a pair of innovative research studies attacking HIV from very different angles. Keith Jerome, Ph.D., of the University of Washington, Seattle, was awarded $344,000 for a project that aims to advance…
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The Justice Department said Monday it would move forward to expand the number of marijuana growers for federally authorized cannabis research. The long-awaited move comes after researchers filed court papers asking a judge to compel the Drug Enforcement Administration to process the applications to grow research pot. The DEA began accepting applications to grow marijuana for federally approved research about…
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As it closes in on one of the most valuable land deals in Seattle history, Alexandria Real Estate Equities is betting that biotech can thrive in a real estate market dominated by big tech. The real estate firm recently reached an agreement with the city of Seattle to buy the Mercer Mega Block, a trio of development sites that lie between Amazon’s campus and…
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How did the first cells on Earth arise? In a minimal cell, a membrane separates proteins and RNA from the surrounding aqueous environment. Cell-like membranes spontaneously assemble from simple prebiotic surfactants called fatty acids. However, fatty acid membranes are unstable in solutions containing salts that were likely present in environments of the early Earth. We find that amino acids, the…
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Acute myeloid leukemia (AML) is commonly treated with allogeneic hematopoietic cell transplantation (HCT). Donor T cells arising from the graft can prevent relapse by targeting leukemia cells. These T cells can bind to antigens expressed by the leukemia cells presented on the cell surface by a major histocompatibility complex (MHC) and eliminate the cancer cells. However, many antigens presented by…
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A drug long used to treat HIV, when paired with chemotherapy and radiotherapy, appears to enhance survival for patients with inoperable non-small cell lung cancer, according to findings published Aug. 22 in JAMA Oncology. The study’s lead author is Dr. Ramesh Rengan, professor and interim chair of radiation oncology at the University of Washington School of Medicine. The research began when he was at…
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Myelodysplastic syndromes (MDS) is a form of blood cancer that is caused by a range of failures of the bone marrow to produce normal functional blood cells. Through reprogramming patient blood cells, researchers recently found a new pathway to study the progression and appropriate treatment of this disease. Bone marrow is responsible for manufacturing healthy blood cells, by originally producing stem cells…
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By using single-cell analysis to measure metabolic activities in rare disseminated tumor cells taken from non-small cell lung cancer (NSCLC) patients, ISB researchers and their collaborators can accurately predict how patients will respond to various cancer therapies, and how treatments will impact a patient’s physiological performance and survival. Additionally, researchers pinpointed the molecular basis underlying these metabolic states and identified…
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