Supercharging Antibodies for Better Medicine

Form follows function in the latest chapter of a fruitful collaboration involving two University of Washington research centers – the Institute for Stem Cell and Regenerative Medicine (ISCRM) and the Institute for Protein Design (IPD). In this case, the integration of form and functions refers to a technology in which computer-designed proteins drive the assembly of antibody proteins into well-defined structures known…
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 Outpace Bio raised a $30 million Series A investment round to design custom cell and gene-based therapies. Founded in November, the Seattle startup is developing software and hardware to manipulate how cells interact with diseases. Its initial work is focused on T cell therapies that fight solid tumors. The 18-person company also announced a partnership with San Francisco startup Lyell…
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Scientists at Fred Hutchinson Cancer Research Center have found laboratory evidence that patients who have been infected with the COVID-19 virus and are subsequently vaccinated against it mount a stronger immune defense than those who were vaccinated but never infected with the virus. In a paper posted online on March 25 by the journal Science, a Fred Hutch team led by Drs. Leo…
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Omics Made Easier

Omes and omics are proliferating these days: Genomics. Proteomics. Metabolomics. But what are they? What’s the point of ome-ing everything? An “ome” is a totality. So a genome is all the DNA, including the genes, in a cell or organism. All of our proteins make up our proteome. Omic technologies allow researchers to see a more-complete picture of the ome…
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The goal of personalized medicine is to match the right drugs to the right patients at the right time. Personalized medicine has been most successful in cases where there is a clear genetic linkage between a disease and a therapy. This is not the case with type 1 diabetes (T1D), a genetically complex immune-mediated disease of β-cell destruction. Researchers over…
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A new virus-based tool is lighting up the brain in glowing — and highly specific — colors. Two studies, led by researchers at the Allen Institute for Brain Science, a division of the Allen Institute, were published today in the journals Neuron and Cell Reports and describe modified viruses that can deliver fluorescent labels to a single cell type in the mouse, monkey or…
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Dr. Rachel Issaka is a gastroenterologist at Seattle Cancer Care Alliance (SCCA) and UW Medical Center and a health services researcher with the Fred Hutchinson Institute for Cancer Outcomes Research. She specializes in digestive issues associated with cancer or cancer treatment. Dr. Issaka’s research is dedicated to reducing racial disparities in colorectal cancer outcomes by developing novel ways to reach, screen, and ensure follow-up…
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ITHS Welcomes the 2021 Pilot Awardees

The Institute of Translational Health Sciences is pleased to announce the 2021 Pilot Award recipients. Applicants were selected from across a broad range of disciplines spanning the translational science spectrum, including basic research, clinical implementation, public health, and clinical and pre-clinical research. Investigators supported by the Pilot Program are expanding knowledge in rural health care delivery, tissue bioengineering, suicide prevention,…
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 Bristol Myers Squibb and bluebird bio, Inc. today announced that the U.S. Food and Drug Administration (FDA) has approved Abecma (idecabtagene vicleucel; ide-cel) as the first B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T cell immunotherapy for the treatment of adult patients with relapsed or refractory multiple myeloma after four or more prior lines of therapy, including an immunomodulatory agent, a…
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Researchers have developed experimental flu shots that protect animals from a wide variety of seasonal and pandemic influenza strains. The vaccine product is currently being advanced toward clinical testing. If proven safe and effective, these next-generation influenza vaccines may replace current seasonal options by providing protection against many more strains that current vaccines do not adequately cover. A study detailing how the…
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