The Institute for Catalan Studies (IEC), based in Barcelona, Spain, has named UW Professor of Bioengineering Albert Folch as a member of its Science and Technology Section. Folch was recognized with the honor during a Plenary session June 15, along with three other new fellows in the Science and Technology Section and the Historical-Archaeological Section. The Institute for Catalan Studies is a national…
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The microRNAs are non-coding RNAs which post-transcriptionally regulate the expression of many eukaryotic genes, and whose dysregulation is a driver of human disease. Here we report the discovery of a very slow (0.1 s−1) conformational rearrangement at the Dicer cleavage site of pre-miR-21, which regulates the relative concentration of readily- and inefficiently-processed RNA structural states. We show that this dynamic switch is affected by…
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Statins are one of the most prescribed drugs in the developed world and have proven to be effective in lowering cholesterol levels and decreasing the risks of heart attack and stroke. However, like antibiotics, there is a flip side to their use. Side effects of statin use, for example, include an increased risk of developing type 2 diabetes. ISB Assistant…
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Fred Hutchinson Cancer Center is leveraging Amazon’s machine learning expertise to collaborate on an early-stage clinical trial testing an anti-cancer vaccine in patients with certain types of breast cancer or melanoma. The trial was posted on a government clinical trial database in October and will explore the safety of the vaccine, which will be personalized for patients with late-stage melanoma or metastatic…
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Read the Publication This week we profile a recent publication in The Journal of Infectious Diseases from Dr. Zoe Moodie (left) and the laboratory of Dr. Juliana McElrath (right) at Fred Hutch. Can you provide a brief overview of your lab’s current research focus? The McElrath laboratory applies multi-disciplinary and cross-platform approaches to their studies, which encompass the following research…
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The Institute for Protein Design is an innovation factory. Since launching a decade ago, the University of Washington institution has grown to about 200 researchers and spun out eight startups wielding protein-design software to forge new drugs, vaccines, and enzymes. IPD spinouts have collectively raised more than $1 billion and helped fuel a biotech boom in Seattle, where they have all landed.…
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Seattle’s Life Sciences Boom

Seattle remains a major hub for talent in life sciences research — a burgeoning industry that faces an intense labor crunch nationwide amid rapid growth — according to a recent report published by the investment management firm CBRE. Driving the news: Seattle came in No. 9 in CBRE’s ranking of life sciences clusters, based on cities’ jobs, local wages, cost…
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While there are routine reminders to eat fiber, whole foods, the right vegetables and the right carbohydrates, one important topic is typically left out of the conversation on a diet for a healthy gut, said Dr. Chris Damman, a gastroenterologist with the University of Washington School of Medicine. He studies the effect of nutrition on health by way of the…
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ISB Honors Researchers Who Give Back to STEM Education

ISB Education’s mission is to ensure quality STEM education is a reality for every student. The team carries this out by working with every part of the education system – teachers, administrators, students, and importantly, scientists and other STEM professionals. ISB’s own scientists selflessly share their time and expertise to make this mission a reality. Since 2019, we have recognized…
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DNA Typewriter Taps Out a Record Inside Cells

To test their DNA typewriter, scientists sought to hide well-known phrases inside cells. But this invention’s most powerful application may lie in documenting the biological events that unfold within the boundaries of normal and diseased cells. While developing a new system for recording within cells, geneticist Jay Shendure and his team decided to give it a test run by using it to…
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