Dr. Trevor Bedford, an infectious disease scientist at Fred Hutchinson Cancer Research Center, was selected as a recipient of the 2021 MacArthur Fellowship. Also known as the MacArthur “genius grant,” the honor is awarded annually by the John D. and Catherine T. MacArthur Foundation and provides $625,000 in “no-strings-attached” funding over five years to allow recipients to pursue creative, intellectual and professional…
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As Prostate Cancer Awareness Month comes to a close, researchers want to circulate the message that some gene mutations linked to breast and ovarian cancer are also associated with prostate cancer. Both sexes have the same risk for inherited gene mutations, such as BRCA1/2 and PALB2, and the same chances of passing the mutation to their children. Yet women were 10 times…
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Astellas Pharma Inc. and Seagen Inc. announced that Japan’s Ministry of Health, Labour and Welfare (MHLW) has approved PADCEV®(enfortumab vedotin) for radically unresectable urothelial carcinoma that has progressed after anti-cancer chemotherapy. The New Drug Application received priority review. Radically unresectable urothelial carcinoma is urothelial cancer that cannot be treated by surgical removal of the urinary bladder or the kidney and…
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Dr. Berger Wins Additional WRF Translational Funding

Washington Research Foundation (WRF) has awarded a $700,000 phase three technology commercialization grant to Stephanie Berger, Ph.D., to support the development of an oral biologic for inflammatory bowel disease (IBD). Berger, a translational investigator at the Institute for Protein Design, received two previous grants totaling $300,500 from WRF for this work. IBD affects roughly three million people in the United…
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President Biden announced 30 of America’s most distinguished leaders in science and technology as members of his President’s Council of Advisors on Science and Technology (PCAST). A direct descendant of the scientific advisory committee established by President Eisenhower in 1957 in the weeks after the launch of Sputnik, PCAST is the sole body of external advisors charged with making science, technology,…
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Heart failure remains a significant cause of morbidity and mortality following myocardial infarction. Cardiac remuscularization with transplantation of human pluripotent stem cell-derived cardiomyocytes is a promising preclinical therapy to restore function. Recent large animal data, however, have revealed a significant risk of engraftment arrhythmia (EA). Although transient, the risk posed by EA presents a barrier to clinical translation. We hypothesized…
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Three Seattle scientists who have been studying the coronavirus have been selected among hundreds for national biomedical funding that offers millions of dollars toward their research, positioning them for possible scientific breakthroughs down the road. Trevor Bedford, Frederick Matsen IV and David Veesler are among 33 researchers recognized this year by the Howard Hughes Medical Institute (HHMI), the largest private biomedical research…
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In the neocortex, subcerebral axonal projections originate largely from layer 5 (L5) extratelencephalic-projecting (ET) neurons. The unique morpho-electric properties of these neurons have been mainly described in rodents, where retrograde tracers or transgenic lines can label them. Similar labeling strategies are infeasible in the human neocortex, rendering the translational relevance of findings in rodents unclear. We leveraged the recent discovery…
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One of your key points was that the “missense variants of unknown significance (VUS) represent a large and growing problem.” Why is this and how does your answer relate to the “bold prediction” of the seminar, “The clinical relevance of all encountered genomics will be readily predicable, rendering the diagnostic designation VUS obsolete? VUS are a large and growing problem…
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