Chinook Therapeutics, Inc. (NASDAQ: KDNY), a biopharmaceutical company focused on the discovery, development and commercialization of precision medicines for kidney diseases, today announced that dosing has been initiated in a phase 1 clinical trial evaluating CHK-336 in adult healthy volunteers. CHK-336 is an oral small molecule lactate dehydrogenase A (LDHA) inhibitor with liver-targeted tissue distribution being developed for the treatment of patients with primary hyperoxaluria (PH) and secondary hyperoxaluria due to increased endogenous oxalate production.
“The initiation of the phase 1 clinical trial of CHK-336 is an important milestone for Chinook as it is our first internally discovered program, and has a differentiated profile as an oral small molecule with potential to be a first-in-class therapy for patients with multiple types of hyperoxalurias,” said Andrew King, D.V.M., Ph.D., chief scientific officer of Chinook. “CHK-336 exemplifies Chinook’s commitment to discovering and developing novel precision medicines for rare, severe chronic kidney diseases with defined genetic and molecular drivers.”
