A recent study examined how markers of inflammation and angiogenesis in patients with pulmonary arterial hypertension were related to clinical outcomes across disease subtypes.
This was a translational retrospective study that explored how cytokine levels were associated with mortality, and how the strength of those connections depended on specific disease subtypes.
Patients with connective tissue disease-associated pulmonary hypertension generally had an elevated cytokine profile compared to other subtypes. Some of these cytokine elevations were associated with higher rates of patient mortality. In some cases, cytokines were associated with mortality in the connective tissue disease subtyp
