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A Seesaw Between Transcription and Translation Restrains Bladder Carcinogenesis

By June 23, 2023No Comments

What is it that makes a good story, one that catches your attention and refuses to let go? Does it include a peculiar mystery? A well-motivated conflict which craves resolution? A catchy hook? A recent study from the Hsieh Lab in the Human Biology Division at Fred Hutch, led by postdoctoral associate Dr. Sujata Jana, checks all of these boxes.

The Hsieh Lab broadly studies the interplay between transcriptional and translational regulation in cancer, with a particular focus on cancers of the genitourinary system. Their latest work, published in Cancer Cell, took aim at a mysterious protein called ARID1A—a chromatin-remodeling component that had recently been identified as a tumor suppressor commonly mutated in bladder cancers.