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Proteogenomic Analysis of Chemo-Refractory High-Grade Serous Ovarian Cancer

By August 7, 2023No Comments

To improve the understanding of chemo-refractory high-grade serous ovarian cancers (HGSOCs), scientists characterized the proteogenomic landscape of 242 (refractory and sensitive) HGSOCs, representing one discovery and two validation cohorts across two biospecimen types (formalin-fixed paraffin-embedded and frozen). They identified a 64-protein signature that predicts with high specificity a subset of HGSOCs refractory to initial platinum-based therapy and is validated in two independent patient cohorts. They detected significant association between lack of Ch17 loss of heterozygosity (LOH) and chemo-refractoriness.