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Interleukin-4 Downregulates Transcription Factor BCL6 to Promote Memory B Cell Selection in Germinal Centers

By May 2, 2024No Comments

Researchers showed that IL-4 cytokine signaling in GC B cells directly downregulated the transcription factor BCL6 via negative autoregulation to release cells from the GC program and to promote MBC formation. This selection event required additional survival cues and could therefore result in either GC exit or death.