In an article published today in the journal Nature Communications, Benaroya Research Institute (BRI) scientists led by Peter Linsley, PhD and Karen Cerosaletti, PhD examined islet antigen reactive (IAR) T cells and compared T cell receptor (TCR) junction sequences in at-risk, type 1 diabetes (T1D) and healthy control patients. They found a significant fraction of IAR TCRs circulating in peripheral blood that share matching TCR alpha (TRA) chains with pancreatic infiltrating T cell (PIT) TCRs, and vice versa.
