How Clams Provide Clues into Cancer Evolution

The key to learning about cancer evolution in humans may be found by studying a surprising organism: the clam. PNRI scientist Dr. Michael Metzger seeks to understand the principles of how cancer evolves and how some organisms can resist cancer by looking for discovery in an unexpected place through studying transmissible cancers in bivalves: mussels, oysters, cockles, scallops, and clams. What is…
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Your Questions Answered about New Therapy to Delay T1D

Scientists at the Benaroya Research Institute (BRI) and TrialNet, a global type 1 diabetes (T1D) research consortium, have spent decades working to answer a bold question: Can we stop T1D before it starts? The FDA recently approved a therapy that marks a huge milestone in preventing T1D. This therapy, teplizumab, can delay T1D for a median of two years. “Not only is this…
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Seattle vaccine startup Curevo, which is developing a vaccine against shingles, raised $26 million. The funding comes on the heels of $60 million raised in February to advance the company’s clinical trial for its shot against shingles, a painful condition caused by reactivation of the virus that causes chicken pox. The startup aims to develop a shingles vaccine with a better safety profile…
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A recent study examined how markers of inflammation and angiogenesis in patients with pulmonary arterial hypertension were related to clinical outcomes across disease subtypes. This was a translational retrospective study that explored how cytokine levels were associated with mortality, and how the strength of those connections depended on specific disease subtypes. Patients with connective tissue disease-associated pulmonary hypertension generally had an…
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Seattle biotech giant Seagen has appointed a new CEO, David Epstein, a former executive at Novartis. Epstein also joined the company’s board of directors. Epstein take the helm of the company six months after Seagen co-founder and longtime CEO Clay Siegall resigned from the role in the wake of allegations of domestic abuse and an incident at his home where he was arrested. Siegall, who…
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If an epilepsy patient needs brain surgery, their brain surgeon often extracts a piece of tissue the size of a sugar cube from the outermost layer to access the regions responsible for the seizures. This excised lump is typically discarded as medical waste since it is far from the diseased site. But to neuroscientists like Jonathan Ting, Ph.D., this brain nugget…
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A new study shows that when an experimental cancer medication is split in half, the molecule becomes safer and more effective. Scientists at the University of Washington School of Medicine were looking for ways to improve a promising cancer drug called Neo-2/15. This protein was created to mimic the function of Interleukin-2, or IL-2, which is a natural molecule that can…
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Scientists for the first time have used CRISPR to substitute a gene to treat patients with cancer. The remarkable findings were published in the journal Nature and presented at the Society for Immunotherapy of Cancer (SITC) 2022. Cancer treatments, while targeted at cancer cells, can often also impact healthy tissues and lead to serious side effects. The reported approach first identifies T cells…
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Seattle biotech startup Bonum Therapeutics raised $93 million less than two months after its parent company Good Therapeutics was bought for $250 million by Roche, with the potential for milestone payments. Bonum founder and CEO John Mulligan hopes to repeat the success of Good Therapeutics by using the same platform technology and potentially leveraging a similar future buyout structure. Big pharma companies typically buy an entire…
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If an epilepsy patient needs brain surgery, their brain surgeon often extracts a piece of tissue the size of a sugar cube from the outermost layer to access the regions responsible for the seizures. This excised lump is typically discarded as medical waste since it is far from the diseased site. But to neuroscientists like Jonathan Ting, Ph.D., this brain nugget…
Read More