Cracking the Code of Addiction

Reward is essential for life. Our brains flood with feel-good chemicals when we learn, eat, have sex. But these essential brain circuits are hijacked in drug addiction. Neuroscientists at the Allen Institute and the University of North Carolina are working to crack the biology of reward and addiction. Hear about their work and their hopes for the future of treating…
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We were delighted to have Alpenglow CEO Nick Reder, MD MPH participate in this recent interview with Sebastien Latapie, Principal at Dynamk Capital.  3D spatial biology is an exciting new space and Dynamk wanted to learn more about how Alpenglow is using its technology to accelerate drug discovery.  Hear about the motivation for developing the technology, the advantages of 3D…
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Florence Chardon and Moez Dawood, two BBI researchers based in Dr. Lea Starita’s lab, recently presented on their work at the international conference, “CRISPR and Beyond” in the U.K. Here are some of their reflections.  At the CRISPR and Beyond conference, I presented on my and Troy McDiarmid’s (a postdoctoral fellow in Jay Shendure’s lab) work using CRISPR activation to…
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Around half of your brain is made up of cells that are not neurons. Among those are octopus-like microglia, which act as the brain’s janitor and paramedic, consuming dead cells, pathogens and harmful protein clusters that cause disease. These shape-shifting cells, the primary immune cells in the brain, are closely related to blood cells. Their tentacle-like arms can move around…
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Developing a Neuromuscular Modeling System

Over the last two years, researchers at the Institute for Stem Cell and Regenerative Medicine (ISCRM) have been using skeletal muscle derived from induced pluripotent stem cells (iPSC) to study how neuromuscular diseases develop and to test potential therapeutics. However, there is an important shortcoming. Current approaches do not provide a full picture of neurodegenerative diseases like amyotrophic lateral sclerosis (ALS), Charcot-Marie-Tooth…
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The Bezos family has committed $710.5 million over the next decade to accelerate Fred Hutchinson Cancer Center’s multifaceted approach to scientific discovery. The gift supports the organization’s efforts to dramatically accelerate the pace and breadth of medical breakthroughs in cancer and infectious disease by tapping the full potential of today’s science. Organizational leaders expect these efforts to require $3 billion…
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What are multi-omics? Why does our microbiome matter? What’s the difference between genetics and genomics? What is a digital twin? ISB and Seattle Science Foundation have partnered to create videos answering questions like these and more, showcasing ISB scientists and their work. We have created a playlist on our YouTube channel collecting all six videos in the series. Watch each…
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TwinStrand Biosciences’ co-founder Jesse Salk has stepped down from the CEO role, according to a statement issued by the Seattle biotech company Friday. Salk will remain as chief scientific officer and a member of the board. Healthcare industry veteran Chad Brown, a former exec at Nanostring and Qiagen, has stepped in as interim CEO. Brown is also a board member at TwinStrand.
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Like many autoimmune diseases, Type 1 diabetes stems from effector T cells gone rogue. The immune cells launch an attack on the insulin-producing beta islet cells in the pancreas, leaving patients without the ability to process glucose. As a result, patients require lifelong insulin treatment. With the advent of T-cell therapies, scientists have been looking to the body’s own defense…
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Levels of key immune-signaling molecules in the vagina “undergo clear and consistent” fluctuations during the menstrual cycle, a UW Medicine-led team reports in a study published today in the journal BMC Medicine. The findings might help researchers better understand the immune system’s role in fertility, and guide scientists’ efforts to develop vaccines and treatments for infectious disease. A meta-analysis of…
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