Publications of the Week Zebrafish Cutaneous Injury Models Reveal That Langerhans Cells Engulf Axonal Debris in Adult Epidermis Peterman, E., et al. | January 2, 2024 Somatosensory neurons extend enormous peripheral axons to the skin, where they detect diverse environmental stimuli.…karnottJanuary 2, 2024 Read More
Publications of the Week Targeting the Fibroblast Growth Factor Pathway in Molecular Subtypes of Castration-Resistant Prostate Cancer Labrecque, M., et al. | December 14, 2023 Androgen receptor (AR) pathway inhibition remains the cornerstone for prostate cancer therapies. However, castration-resistant prostate…karnottDecember 14, 2023 Read More
Publications of the Week A First-in-Human, Open-Label Phase 1b and a Randomised, Double-Blind Phase 2a Clinical Trial in Recent-Onset Type 1 Diabetes with AG019 As Monotherapy and in Combination with Teplizumab Mathieu, C., et al. | December 13, 2023 We hypothesised that islet beta cell antigen presentation in the gut along with a tolerising…karnottDecember 13, 2023 Read More
Publications of the Week A Standard Workflow for Community-Driven Manual Curation of Strongyloides Genome Annotations Bryant, A., et al. | December 8, 2023 Advances in the functional genomics and bioinformatics toolkits for Strongyloides species have positioned these species as genetically…karnottDecember 8, 2023 Read More
Publications of the Week Expression of the Vesicular GABA Transporter within Neuromedin S+ Neurons Sustains Behavioral Circadian Rhythms Bussi, I.L., et al. | December 5, 2023 The suprachiasmatic nucleus (SCN) of the hypothalamus is the site of a central circadian clock…sciencecityDecember 5, 2023 Read More
Publications of the Week Flipped C-Terminal Ends of ApoA1 Promote ABCA1-Dependent Cholesterol Efflux by Small HDLs He, Y., et al. | December 1, 2023 Cholesterol efflux capacity (CEC) predicts cardiovascular disease independently of high-density lipoprotein (HDL) cholesterol levels. Isolated…sciencecityDecember 1, 2023 Read More
Publications of the Week Multi-Omic Analysis of Human Kidney Tissue Identified Medulla-Specific Gene Expression Patterns Haug, S., et al. | November 29, 2023 The kidney medulla is a specialized region with important homeostatic functions. It has been implicated…sciencecityNovember 29, 2023 Read More
Publications of the Week T Cell Receptor Sequences Are the Dominant Factor Contributing to the Phenotype of CD8+ T Cells with Specificities Against Immunogenic Viral Antigens Chen, D., et al. | November 24, 2023 This week, Science in Seattle profiles Dr. Jim Heath (pictured). Dr. Heath is President and…karnottNovember 24, 2023 Read More
Publications of the Week Probing Cerebral Malaria Inflammation in 3D Human Brain Microvessels Howard, C., et al. | November 23, 2023 Sequestration of Plasmodium falciparum-infected erythrocytes (IEs) in the brain microcirculation is a hallmark of cerebral…karnottNovember 23, 2023 Read More
Publications of the Week Embryo-Scale Reverse Genetics at Single-Cell Resolution Saunders, L., et al. | November 22, 2023 The maturation of single-cell transcriptomic technologies has facilitated the generation of comprehensive cellular atlases from…karnottNovember 22, 2023 Read More