Publications of the Week Inhibition of Hedgehog Signaling Does Not Mitigate Polycystic Kidney Disease Severity in a Pkd1 Mutant Mouse Model Gombart, S., et al. | October 14, 2025 Autosomal dominant polycystic kidney disease (ADPKD) is a monogenic disorder caused by mutations in PKD1…karnottOctober 14, 2025 Read More
Publications of the Week Fusobacterium sphaericum Sp. Nov., Isolated From a Human Colon Tumor Adheres To Colonic Epithelial Cells and Induces IL-8 Secretion Zepeda-Riveraa, M., et al. | October 10, 2025 Cancerous tissue is a largely unexplored microbial niche that provides a unique environment for the…karnottOctober 10, 2025 Read More
Publications of the Week Breast Milk IgG Engages the Mouse Neonatal Immune System To Instruct Responses to Gut Antigens Shenoy, M., et al. | October 1, 2025 Mammals must initiate regulatory mechanisms to limit inflammatory responses to components of food and the…karnottOctober 1, 2025 Read More
Publications of the Week Progression To Rheumatoid Arthritis in At-Risk Individuals Is Defined by Systemic Inflammation and by T and B Cell Dysregulation Science Translational Medicine | September 29, 2025 Individuals who go on to develop rheumatoid arthritis (RA) experience a stage of disease development…karnottSeptember 29, 2025 Read More
Publications of the Week Genetic and Epigenetic Screens in Primary Human T Cells Link Candidate Causal Autoimmune Variants to T Cell Networks Ho, C., et al. | September 25, 2025 Genetic variants associated with autoimmune diseases are highly enriched within putative cis-regulatory regions of CD4+…karnottSeptember 25, 2025 Read More
Publications of the Week Preventing Hypocontractility-Induced Fibroblast Expansion Alleviates Dilated Cardiomyopathy Bretherton, R., et al. | September 16, 2025 Cardiomyocyte hypocontractility underlies inherited dilated cardiomyopathy (DCM). Yet, whether fibroblasts modify DCM phenotypes remains unclear…karnottSeptember 16, 2025 Read More
Publications of the Week Early and Opposing Neutrophil and CD4 T Cell Responses Shape Pulmonary Tuberculosis Pathology Gern, B., et al. | September 10, 2025 Pulmonary Mycobacterium tuberculosis (Mtb) infection results in a variety of heterogeneous lesion structures, from necrotic…karnottSeptember 10, 2025 Read More
Publications of the Week PhoCoil: A Photodegradable and Injectable Single-Component Recombinant Protein Hydrogel for Minimally Invasive Delivery and Degradation Gregorio, N., et al. | September 4, 2025 Hydrogel biomaterials offer great promise for three-dimensional cell culture and therapeutic delivery. Despite many successes,…karnottSeptember 4, 2025 Read More
Publications of the Week Genetically Encoded Interpenetrating Polymer Networks As Injectable Biomaterials for Controlled Therapeutic Protein Delivery Ross, M., et al. | August 25, 2025 Though recombinant protein therapeutics hold great potential in treating many diseases, their intravenous delivery introduces…karnottAugust 25, 2025 Read More
Publications of the Week Dendritic atoh1a+ Cells Serve As Merkel Cell Precursors During Skin Development and Regeneration Craig, E., et al. | August 20, 2025 Sensory cells often adopt specific morphologies that aid in the detection of external stimuli. Merkel…karnottAugust 20, 2025 Read More