This week on Founded & Funded, Partner Chris Picardo is talking with A-Alpha Bio Co-founder and CEO David Younger for our first Intelligent Application 40 Spotlight episode of 2023. We announced the 2022 IA40 winners in October, and A-Alpha was the first biotech company to make the list, which was no surprise to us. As one of our portfolio companies, we know the work David and…
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A study of kidney organoids in a novel lab environment might have downstream implications for the treatment of polycystic kidney disease (PKD), an incurable condition that affects more than 12 million people worldwide. One key discovery of the study: Sugar appears to play a role in the formation of fluid-filled cysts that are PKD’s hallmark. In people, these cysts grow big…
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The Interior Design of Our Cells

Scientists have just debuted a new way to see how cells organize themselves. Working with hundreds of thousands of high-resolution images, the team at the Allen Institute for Cell Science, a division of the Allen Institute, put numbers on the internal organization of human cells — a biological concept that has to date proven exceptionally difficult to quantify. Through that…
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In November, researchers reported the drug lecanemab slowed the progression of Alzheimer’s disease. The effect was modest, but it has generated tremendous excitement because it was the first time a drug had been shown to be able to affect the course of this relentless, incurable disease. The drug, lecanemab, is a manufactured antibody that helps clear an abnormal protein called…
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Scientists in aging research today report a novel experimental approach that slowed the rate of physical decline and lengthened the lives of roundworms commonly used in biological studies, C. elgans. Their findings are described in the Dec. 30 edition of Nature Aging, a scientific journal in the Springer Nature group. The lead author is Brandon J. Berry, a postdoctoral fellow in the laboratory of…
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Researchers at the Benaroya Research Institute (BRI) and colleagues have published findings today in The Lancet Planetary Health concluding that in the absence of viral infection, elevated air quality index values are associated with asthma exacerbations and lowered lung function in children living in low-income urban neighborhoods. “Until now, the mechanism for how air pollution exacerbates asthma has been poorly understood,” said Matt Altman,…
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A Promising New Approach to Stopping Type 1 Diabetes

What if the cure to type 1 diabetes (T1D) is hiding in your own cells? A team of researchers from BRI and Seattle Children’s Research Institute have been asking this question for years – and it led them to develop a new type of therapy that could someday become a groundbreaking treatment for T1D and other autoimmune diseases. T1D starts…
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When it comes to colorectal cancer, we’re all at risk at least a little, says Ulrike “Riki” Peters, PhD, MPH, a molecular and genetic epidemiologist with Fred Hutchinson Cancer Center. “Many people have average risk, some people have much lower risk and some are at really high risk. But people generally wouldn’t know if they’re at high risk,” said Peters, who…
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The holiday break is a time to pause and gather with family and friends, a time for reflection, a time for rest. But the Fred Hutch campus is not really at rest. A few hearty souls are at work. Mostly out of sight — you’d miss them if you weren’t looking closely, but they are here keeping buildings secure, seeing…
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