Viruses Linked to Type 1 Diabetes in High-Risk Children

Scientists have long suspected that viruses play a role in the development of Type 1 diabetes (T1D), although evidence has not been consistent enough to show a connection. Until now. The Hagopian lab at the Pacific Northwest Research Institute (PNRI) is part of a groundbreaking international study following more than 8,000 children with increased genetic risk for developing T1D, called the TEDDY…
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According to the National Institutes of Health, one in fifteen Americans suffer from an autoimmune disease. Common examples of this include type 1 diabetes, multiple sclerosis, Crohn’s disease, and rheumatoid arthritis. In the Pacific Northwest, there is a greater prevalence of multiple sclerosis, inflammatory bowel disease and type 1 diabetes.  The Sound Life Project is a partnership between the Benaroya Research Institute and the…
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Fine-Tuning CAR T-Cell Immunotherapy to Benefit More Kids

Chimeric antigen receptor (CAR) T-cell immunotherapy, which reprograms a child’s white blood cells so they can seek out and destroy cancer cells, is making a difference in children’s lives. Currently, Seattle Children’s has multiple trials open that could benefit children and young adults with relapsed or refractory cancers. In October, Seattle Children’s opened a new pediatric research facility, Building Cure, to accelerate discoveries…
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Flu season is here, and everyone should be thinking about how to stay healthy as the risk of getting the flu gets higher. Last flu season, our region experienced two waves of flu causing hospitalizations and severe illness for thousands of local residents. This year, the Seattle Flu Study is inviting the Seattle community to join them in finding new…
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For years, leukemia doctors have been plagued by a toxic trade-off: A bull’s-eye for certain cancer-killing drugs also appears on some normal blood stem cells. Hitting the mark means harming healthy and diseased cells alike. Scientists at Fred Hutchinson Cancer Research Center want to get rid of that trade-off altogether. Their strategy: remove the bull’s-eye from normal cells while leaving…
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Researchers at Seattle’s Fred Hutchinson Cancer Research Center have demonstrated the effectiveness of a new method for getting immune cells to fight solid tumors — by spreading them like jam onto ultra-thin sheets of metal mesh, and then laying the mesh onto the tumors. So far, the technique for delivering genetically engineered T cells has been used only on mice — but…
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Embracing Diversity in a Team-Science World

As I prepare to leave my post as leader of Fred Hutchinson Cancer Research Center, my thoughts are turning more than ever toward the next generation of scientists. They will shape our future in a field that is being transformed daily by new discoveries and new technologies. They will work the laboratory benches, crunch the data and envision bold new ways to…
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A common virus that is harmless to most individuals may produce an important biomarker in determining the prognosis of brain cancer patients, according to a recent study published by a student researcher at the University of Cincinnati. Patients with glioblastomas or malignant brain tumors, face a difficult future. The disease is fatal, and only about 5 percent of patients are…
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These Small Proteins Reveal a New Kind of Brain Diversity

Stephen Smith, Ph.D., had been waiting for a certain kind of dataset for a long time. The Allen Institute neuroscientist has a driving interest in brain diversity — not in the sense of how one person’s brain is different from another’s, but in the rich and incredible variation within a single brain. There are a lot of different ways to explore this…
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Drug Discovery Gains Powerful Single Cell Transcriptional Profiling Tool

A foundation of the drug discovery process—high throughput screening—is fraught with limitations. A new technique, sci-Plex, uses nuclear hashing to profile and quantify gene expression in single cells in response to thousands of independent perturbations at single-cell resolution. The technology holds promise for drug discovery of drugs for cancer, infection, prenatal medicine, and other research. “Earlier this year, we reached…
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