Publications of the Week Signaling and Transcriptional Dynamics Underlying Early Adaptation to Oncogenic BRAF InhibitionFlower, C., et al. | March 27, 2025A major contributor to poor sensitivity to anti-cancer kinase inhibitor therapy is drug-induced cellular adaptation,…karnottMarch 27, 2025 Read More
Publications of the Week Interneuron-Specific Dual-AAV SCN1A Gene Replacement Corrects Epileptic Phenotypes in Mouse Models of Dravet SyndromeMich, J., et al. | March 25, 2025Dravet syndrome (DS) is a severe and difficult-to-treat epileptic syndrome usually caused by a loss-of-function…karnottMarch 25, 2025 Read More
Publications of the Week Safety and Efficacy of Acalabrutinib Plus Bendamustine and Rituximab in Patients With Treatment-Naïve or Relapsed/Refractory Mantle Cell Lymphoma: Phase Ib TrialPhillips, T., et al. | March 18, 2025This multicenter, open-label, phase Ib study (ACE-LY-106) assessed the safety and efficacy of acalabrutinib, bendamustine,…karnottMarch 18, 2025 Read More
Publications of the Week RNA Polymerase II at Histone Genes Predicts Outcome in Human CancerHenikoff, S., et al. | March 12, 2025Cancer often exhibits genome-wide hypertranscription, but the mechanisms driving this phenomenon remain unclear. To understand…karnottMarch 12, 2025 Read More
Publications of the Week Layer-by-Layer Functionalized Gauze With Designed α-Sheet Peptides Inhibits E. coli and S. aureus Biofilm FormationNick, S., et al. | March 6, 2025Microbial biofilms on wounds lead to longer hospital stays, mechanical debridement, and higher mortality. Amyloid…karnottMarch 6, 2025 Read More
Publications of the Week De Novo Designed Hsp70 Activator Dissolves Intracellular CondensatesZhang, J., et al. | February 26, 2025Cells constantly use and recycle their proteins in a process called protein quality control (PQC).…karnottFebruary 26, 2025 Read More
Publications of the Week Metagenomic Estimation of Dietary Intake From Human StoolDiener, C., et al. | February 21, 2025Dietary intake is tightly coupled to gut microbiota composition, human metabolism and the incidence of…karnottFebruary 21, 2025 Read More
Publications of the Week Multiplex Generation and Single-Cell Analysis of Structural Variants in Mammalian GenomesPinglay, S., et al. | February 20, 2025The structural variants (SVs) present in mammalian genomes include deletions, insertions, inversions, duplications, translocations, extrachromosomal…karnottFebruary 20, 2025 Read More
Publications of the Week APMAT Analysis Reveals the Association Between CD8 T Cell Receptors, Cognate Antigen, and T Cell Phenotype and PersistenceXie, J., et al. | February 12, 2025Elucidating the relationships between a class I peptide antigen, a CD8 T cell receptor (TCR)…karnottFebruary 12, 2025 Read More
Publications of the Week Tissue-Resident Memory CD8 T Cell Diversity Is Spatiotemporally ImprintedReina-Campos, M., et al. | February 5, 2025This week, we profile a recent publication in Nature by Dr. Maximilian Heeg’s (pictured) lab…karnottFebruary 5, 2025 Read More