Publications of the Week Merkel Cell Polyomavirus-Specific and CD39+CLA+ CD8 T Cells As Blood-Based Predictive Biomarkers for PD-1 Blockade in Merkel Cell CarcinomaRyu, H., et al. | February 15, 2024Merkel cell carcinoma is a skin cancer often driven by Merkel cell polyomavirus (MCPyV) with…karnottFebruary 15, 2024 Read More
Publications of the Week Impact of Rabbit Anti-Thymocyte Globulin (ATG) Exposure on Outcomes After Ex Vivo T-Cell-Depleted Hematopoietic Cell Transplantation in Pediatric and Young Adult PatientsLakkaraja, M., et al. | February 14, 2024Traditional weight-based dosing of rabbit anti-thymocyte globulin (rATG) used in allogeneic hematopoietic cell transplantation (HCT)…karnottFebruary 14, 2024 Read More
Publications of the Week Single-Nucleoid Architecture Reveals Heterogeneous Packaging of Mitochondrial DNAIsaac, R., et al. | February 12, 2024Cellular metabolism relies on the regulation and maintenance of mitochondrial DNA (mtDNA). Hundreds to thousands…karnottFebruary 12, 2024 Read More
Publications of the Week De Novo Design of Modular Protein Hydrogels with Programmable Intra- and Extracellular ViscoelasticityMout, R., et al. | February 7, 2024When researchers want to study how COVID makes us sick, or what diseases such as…karnottFebruary 7, 2024 Read More
Publications of the Week Reversible, Tunable Epigenetic Silencing of TCF1 Generates Flexibility in the T Cell Memory DecisionAbadie, K., et al. | February 6, 2024The immune system encodes information about the severity of a pathogenic threat in the quantity…karnottFebruary 6, 2024 Read More
Publications of the Week Efficient and Sustained FOXP3 Locus Editing in Hematopoietic Stem Cells as a Therapeutic Approach for Ipex SyndromeSingh, S., et al. | February 5, 2024Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic disorder caused by mutations in…karnottFebruary 5, 2024 Read More
Publications of the Week LITAF Protects Against Pore-Forming Protein–Induced Cell Death by Promoting Membrane RepairStefani, C., et al. | January 31, 2024This week, Science in Seattle profiles Drs. Adam Lacy-Hulbert (pictured, right) and Caroline Stefani (left).…karnottJanuary 31, 2024 Read More
Publications of the Week FLIP(C1orf112)-FIGNL1 Complex Regulates RAD51 Chromatin Association to Promote Viability After Replication StressTischler, J., et al. | January 30, 2024Homologous recombination (HR) plays critical roles in repairing lesions that arise during DNA replication and…karnottJanuary 30, 2024 Read More
Publications of the Week DNA Methylation and Chromatin Accessibility Predict Age in the Domestic DogJin, K., et al. | January 25, 2024Across mammals, the epigenome is highly predictive of chronological age. These "epigenetic clocks," most of…karnottJanuary 25, 2024 Read More
Publications of the Week Immune Evasion of Dormant Disseminated Tumor Cells Is Due to Their Scarcity and Can Be Overcome by T Cell ImmunotherapiesGoddard, E., et al. | January 16, 2024The period between “successful” treatment of localized breast cancer and the onset of distant metastasis…karnottJanuary 16, 2024 Read More