Publications of the Week

The Cytochrome P450s (CYPs) enzyme family metabolizes ∼80% of small molecule drugs. Variants in CYPs…

Diabetes increases the risk of both cardiovascular disease and kidney disease. Notably, most of the…

Resource partitioning is central to the incredible productivity of microbial communities, including gigatons in annual…

In silico variant effect predictions are available for nearly all missense variants but played a…

Antibody inhibitors pose an ongoing challenge to the treatment of subjects with inherited protein deficiency…

Protein–protein interactions (PPIs) regulate many cellular processes and engineered PPIs have cell and gene therapy…

RIT1 is a rare and understudied oncogene in lung cancer. Despite structural similarity to other…

Mycobacterium tuberculosis (Mtb) exposure leads to a range of outcomes including clearance, latent TB infection…

Ligands such as insulin, epidermal growth factor, platelet-derived growth factor, and nerve growth factor (NGF)…

Current CD33-targeted immunotherapies typically recognize the membrane-distal V-set domain of CD33. Here, we show decreasing…