Publications of the Week Guselkumab Provides Sustained Domain-Specific and Comprehensive Efficacy Using Composite Indices in Patients with Active Psoriatic ArthritisCoates, L. C., et al. | July 1, 2022The authors evaluate the efficacy of guselkumab for the treatment of active psoriatic arthritis (PsA)…dcorriganJuly 1, 2022 Read More
Publications of the Week Shifting Mutational Constraints in the SARS-CoV-2 Receptor-Binding Domain during Viral EvolutionScience | June 29, 2022SARS-CoV-2 has evolved variants with substitutions in the spike receptor-binding domain (RBD) that impact its…dcorriganJune 29, 2022 Read More
Publications of the Week Chemical Exploration of a Highly Selective Scaffold with Activity against Intracellular Mycobacterium tuberculosisNjikan, S., et al. | June 23, 2022The authors previously identified a phenylthiourea series with activity against intracellular Mycobacterium tuberculosis using a high-throughput,…dcorriganJune 23, 2022 Read More
Publications of the Week Blockade of Interleukin 10 Potentiates Antitumor Immune Function in Human Colorectal Cancer Liver MetastasesSullivan, K. M., et al. | June 21, 2022The authors' central goal is to address is how the immunosuppressive microenvironment created by solid…dcorriganJune 21, 2022 Read More
Publications of the Week Succinate Metabolism in the Retinal Pigment Epithelium Uncouples Respiration from ATP SynthesisHass, D. T., et al. | June 17, 2022Fumarate can be a surrogate for O2 as a terminal electron acceptor in the electron transport…dcorriganJune 17, 2022 Read More
Publications of the Week Chemokines, Soluble PD-L1, and Immune Cell Hyporesponsiveness are Distinct Features of SARS-CoV-2 Critical IllnessMorrell, E. D., et al. | June 16, 2022Critically ill patients manifest many of the same immune features seen in COVID-19, including both…dcorriganJune 16, 2022 Read More
Publications of the Week TNF-α/IFN-γ Synergy Amplifies Senescence-Associated Inflammation and SARS-CoV-2 Receptor Expression via Hyper-Activated JAK/STAT1Kandhaya-Pillai, R., et al. | June 10, 2022Older age and underlying conditions such as diabetes/obesity or immunosuppression are leading host risk factors…pthomsonJune 10, 2022 Read More
Publications of the Week Genome-Wide Protein–DNA Interaction Site Mapping in Bacteria Using a Double-Stranded DNA-Specific Cytosine DeaminaseGallagher, L. A., et al. | June 7, 2022DNA–protein interactions are central to fundamental cellular processes, yet widely implemented technologies for measuring these…pthomsonJune 7, 2022 Read More
Publications of the Week Thymidine Starvation Promotes C-Di-AMP-Dependent Inflammation during Pathogenic Bacterial InfectionTang, Q., et al. | June 2, 2022Antimicrobials can impact bacterial physiology and host immunity with negative treatment outcomes. Extensive exposure to…dcorriganJune 2, 2022 Read More
Publications of the Week Impact of CD19 CAR T Cell Product Type on Outcomes in Relapsed or Refractory Aggressive B-NHLGauthier, J., et al. | June 1, 2022CD19-targeted chimeric antigen receptor-engineered (CD19 CAR) T cells are novel therapies showing great promise for…dcorriganJune 1, 2022 Read More