Publications of the Week Activated Interleukin-7 Receptor Signaling Drives B-Cell Acute Lymphoblastic Leukemia in MiceThomas, K. R., et al. | July 7, 2021One key focus within our lab is to better understand signaling events that alter lymphocyte…kchenJuly 7, 2021 Read More
Publications of the Week Resolution of Tissue Signatures of Therapy Response in Patients with Recurrent GBM Treated with Neoadjuvant Anti-PD1Lu, Y., et al. | July 6, 2021The response of patients with recurrent glioblastoma multiforme to neoadjuvant immune checkpoint blockade has been…kchenJuly 6, 2021 Read More
Publications of the Week Pharmacologic Modulation of RNA Splicing Enhances Anti-Tumor ImmunityLu, S. X., et al. | July 5, 2021Although mutations in DNA are the best-studied source of neoantigens that determine response to immune…kchenJuly 5, 2021 Read More
Publications of the Week Mesenchymal Stromal (Stem) Cell (MSC) Therapy Modulates miR-193b-5p Expression to Attenuate Sepsis-Induced Acute Lung Injurydos Santos, C. C., et al. | June 29, 2021Although mesenchymal stromal (stem) cell (MSC) administration attenuates sepsis-induced lung injury in pre-clinical models, the…kchenJune 29, 2021 Read More
Publications of the Week Monocyte Metabolic Transcriptional Programs Associate with Resistance to Tuberculin Skin Test/Interferon-γ Release Assay ConversionSimmons, J. D., et al. | June 29, 2021After extensive exposure to Mycobacterium tuberculosis (Mtb), most individuals acquire latent Mtb infection (LTBI) defined…kchenJune 29, 2021 Read More
Publications of the Week CMV Exposure Drives Long-Term CD57+ CD4 Memory T Cell Inflation Following Allogeneic Stem Cell TransplantYeh, A. C., et al. | June 25, 2021Donor and recipient cytomegalovirus (CMV) serostatus correlate with transplant related mortality that is associated with…kchenJune 25, 2021 Read More
Publications of the Week The PI3K/mTOR Inhibitor Gedatolisib Eliminates Dormant Breast Cancer Cells in Organotypic Culture, but Fails to Prevent Metastasis in Preclinical SettingsShor, R. E., et al. | June 23, 2021The authors study breast cancer metastasis and the biology of disseminated tumor cells (DTCs) and…kchenJune 23, 2021 Read More
Publications of the Week Tumors Overcome the Action of the Wasting Factor ImpL2 by Locally Elevating Wnt/WinglessLee, J., et al. | June 16, 2021My lab uses Drosophila melanogaster as a model to study cancer-related processes, such as cachexia…kchenJune 16, 2021 Read More
Publications of the Week Selective Inhibition of Phosphodiesterase 7 Enzymes Reduces Motivation for Nicotine Use through Modulation of Mesolimbic Dopaminergic TransmissionCiccocioppo, R. et al. | June 15, 2021Background: About 5 million people die from diseases related to nicotine addiction and tobacco use…kchenJune 15, 2021 Read More
Publications of the Week Generation of Ordered Protein Assemblies Using Rigid Three-Body FusionVulovic, I. et al. | June 10, 2021Protein nanomaterial design is an emerging discipline with applications in medicine and beyond. A long-standing…kchenJune 10, 2021 Read More