Publications of the Week Selective Inhibition of Phosphodiesterase 7 Enzymes Reduces Motivation for Nicotine Use through Modulation of Mesolimbic Dopaminergic TransmissionCiccocioppo, R. et al. | June 15, 2021Background: About 5 million people die from diseases related to nicotine addiction and tobacco use…kchenJune 15, 2021 Read More
Publications of the Week Generation of Ordered Protein Assemblies Using Rigid Three-Body FusionVulovic, I. et al. | June 10, 2021Protein nanomaterial design is an emerging discipline with applications in medicine and beyond. A long-standing…kchenJune 10, 2021 Read More
Publications of the Week Identification of In Vivo Hox13-Binding Sites Reveals an Essential Locus Controlling Zebrafish Brachyury ExpressionYe, Z., et al. | June 8, 2021My lab studies how the early vertebrate embryo forms using zebrafish as a model system.…kchenJune 8, 2021 Read More
Publications of the Week Live-Attenuated RNA Hybrid Vaccine Technology Provides Single-Dose Protection against Chikungunya VirusVoigt, A. E., at al. | June 7, 2021We present a live-attenuated RNA hybrid vaccine technology which uses an RNA vaccine delivery vehicle…kchenJune 7, 2021 Read More
Publications of the Week A Taxonomy of Transcriptomic Cell Types across the Isocortex and Hippocampal FormationYao, Z., et al. | June 2, 2021Our team at the Allen Institute for Brain Science studies cell type diversity in the…kchenJune 2, 2021 Read More
Publications of the Week mRNA Translation Is a Therapeutic Vulnerability Necessary for Bladder Epithelial TransformationJana, S., et al. | June 1, 2021Our laboratory studies the process of mRNA translation in normal cell physiology and disease. We…kchenJune 1, 2021 Read More
Publications of the Week Selective Androgen Receptor Modulators Activate the Canonical Prostate Cancer Androgen Receptor Program and Repress Cancer GrowthNyquist, D. M., et al. | May 28, 2021Prostate cancer (PC) is driven by androgen receptor (AR) activity, a master regulator of prostate…kchenMay 28, 2021 Read More
Publications of the Week A Photoswitchable GPCR-Based Opsin for Presynaptic InhibitionCopits, A. B., et al. | May 26, 2021The authors focus on neuromodulatory processing in the brain, as it relates to effective behavior.…kchenMay 26, 2021 Read More
Publications of the Week Enhancer Viruses for Combinatorial Cell-Subclass-Specific LabelingDaigle, L. T., et al. | May 20, 2021The authors are developing adeno-associated viruses (AAVs) and transgenic tools to target and perturb a…kchenMay 20, 2021 Read More
Publications of the Week Tissue Context Determines the Penetrance of Regulatory DNA VariationHalow, M. J., et al. | May 19, 2021Functional assessment of disease-associated sequence variation at non-coding regulatory elements is complicated by their high…kchenMay 19, 2021 Read More