Publications of the Week Synthetic Lethal Kinases in Ras/p53 Mutant Squamous Cell Carcinoma Moser, R., et al. | May 23, 2022 The authors use patient-derived tumor cells to identify and validate new drug targets as well…dcorriganMay 23, 2022 Read More
Publications of the Week Modified Manufacturing Process Modulates CD19 CAR T Cell Engraftment Fitness and Leukemia-Free Survival in Pediatric and Young Adult Subjects Ceppi, F., et al. | May 20, 2022 T cells modified to express a chimeric-antigen receptor (CAR)targeting CD19 can induce potent and sustained…dcorriganMay 20, 2022 Read More
Publications of the Week A Recombinant Alpha-Like Protein Subunit Vaccine (GBS-NN) Provides Protection in Murine Models of Group B Streptococcus Infection Get Access Arrow Brokaw, A., et al. | May 19, 2022 Group B Streptococcus (GBS) transmission during pregnancy causes preterm labor, stillbirths, fetal injury, or neonatal infections.…dcorriganMay 19, 2022 Read More
Publications of the Week Extricating Human Tumor Immune Alterations from Tissue Inflammation Nature | May 16, 2022 The authors compared human tumor tissues to non-malignant, inflamed tissues and observed extensive phenotypic and…dcorriganMay 16, 2022 Read More
Publications of the Week Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon Matas, J., et al. | May 13, 2022 Although somatic mutations in colorectal cancer are well characterized, little is known about the accumulation…dcorriganMay 13, 2022 Read More
Publications of the Week Blockade of TGF-β (Transforming Growth Factor Beta) Signaling by Deletion of Tgfbr2 in Smooth Muscle Cells of 11-Month-Old Mice Alters Aortic Structure and Causes Vasomotor Dysfunction Lee, C. Y., et al. | May 12, 2022 The authors showed that TGF-β signaling in smooth muscle cells during embryogenesis and early postnatal…dcorriganMay 12, 2022 Read More
Publications of the Week Development of [211At]astatine-Based Anti-CD123 Radioimmunotherapy for Acute Leukemias and Other CD123+ Malignancies Laszlo, G. S., et al. | May 6, 2022 Read the Publication This week we profile a recent publication in Leukemia from Dr. George…dcorriganMay 6, 2022 Read More
Publications of the Week Simultaneous Brain Cell Type and Lineage Determined by scRNA-Seq Reveals Stereotyped Cortical Development Anderson, D. J., et al. | May 2, 2022 The authors show that a commonly occurring type of somatic mutation, loss of heterozygosity (LOH),…dcorriganMay 2, 2022 Read More
Publications of the Week Autocrine and Paracrine IL-2 Signals Collaborate to Regulate Distinct Phases of CD8 T Cell Memory Toumi, R., et al. | April 28, 2022 Differential interleukin-2 (IL-2) signaling and production are associated with disparate effector and memory fates. Whether…dcorriganApril 28, 2022 Read More
Publications of the Week Human Cerebellar Development and Transcriptomics: Implications for Neurodevelopmental Disorders Haldipur, P., Millen, K. J., and Aldinger, K. A. | April 28, 2022 Developmental abnormalities of the cerebellum are among the most recognized structural brain malformations in human…dcorriganApril 28, 2022 Read More