Publications of the Week Interplay of Disordered and Ordered Regions of a Human Small Heat Shock Protein Yields an Ensemble of ‘Quasi-Ordered’ StatesClouser, A.F., et al. | October 17, 2019Up to 40% of the human proteome, including human small heat shock proteins (sHSPs) and…sciencecityOctober 17, 2019 Read More
Publications of the Week Constitutive XBP-1s-Mediated Activation of the Endoplasmic Reticulum Unfolded Protein Response Protects against Pathological TauWaldherr, S.M., et al. | October 15, 2019To endure over the organismal lifespan, neurons utilize multiple strategies to achieve protein. To identify…sciencecityOctober 15, 2019 Read More
Publications of the Week N6-Methyladenosine mRNA Marking Promotes Selective Translation of Regulons Required for Human ErythropoiesisKuppers, D.A., et al. | October 11, 2019Many of the regulatory features governing erythrocyte specification, maturation, and associated disorders remain enigmatic. To…sciencecityOctober 11, 2019 Read More
Publications of the Week γ-Secretase Inhibition Increases Efficacy of BCMA-Specific Chimeric Antigen Receptor T Cells in Multiple MyelomaPont, M., et al. | October 9, 2019B cell maturation antigen (BCMA) is a validated target for chimeric antigen receptor (CAR) T…sciencecityOctober 9, 2019 Read More
Publications of the Week MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the MicrobiotaKoyama, M., et al. | October 7, 2019While the effector pathways that mediate graft-versus-host disease (GVHD) are well established (i.e. donor T…sciencecityOctober 7, 2019 Read More
Publications of the Week Suppression of Monosodium Urate Crystal-Induced Inflammation by Inhibiting TGF-β-Activated Kinase 1-Dependent Signaling: Role of the Ubiquitin Proteasome SystemSingh, A.K., et al. | October 3, 2019Monosodium urate (MSU) crystals activate inflammatory pathways that overlap with interleukin-1β (IL-1β) signaling. However, the…sciencecityOctober 3, 2019 Read More
Publications of the Week Functional Metagenomics-Guided Discovery of Potent Cas9 Inhibitors in the Human MicrobiomeForsberg, K.J., et al. | September 30, 2019CRISPR-Cas systems protect bacteria and archaea from phages and other mobile genetic elements, which use…sciencecitySeptember 30, 2019 Read More
Publications of the Week A Lineage-Resolved Molecular Atlas of C. Elegans Embryogenesis at Single-Cell ResolutionPacker, J.S., et al. | September 27, 2019Single-cell RNA sequencing provides the power to identify the developmental trajectory of an organism. However,…sciencecitySeptember 27, 2019 Read More
Publications of the Week Tissue Chips in Space — Challenges and OpportunitiesYeung, C.K., et al. | September 25, 2019The microgravity environment results in a multitude of physiological changes associated with aging and altered…sciencecitySeptember 25, 2019 Read More
Publications of the Week Cell-Specific Image-Guided Transcriptomics Identifies Complex Injuries Caused by Ischemic Acute Kidney Injury in MiceMiyazaki, T., et al. | September 24, 2019The highly heterogeneous nature of the kidney’s tubular epithelium has made it challenging to identify…sciencecitySeptember 24, 2019 Read More