Publications of the Week Clonal Kinetics and Single-Cell Transcriptional Profiling of CAR-T Cells in Patients Undergoing CD19 CAR-T ImmunotherapySheih, A., et al. | January 14, 2020Chimeric antigen receptor (CAR) T-cell therapy has produced remarkable anti-tumor responses in patients with B-cell…sciencecityJanuary 14, 2020 Read More
Publications of the Week Cross-Reactivity with Self-Antigen Tunes the Functional Potential of Naive B Cells Specific for Foreign AntigensSteach, H.R., et al. | January 13, 2020Upon Ag exposure, naive B cells expressing BCR able to bind Ag can undergo robust…sciencecityJanuary 13, 2020 Read More
Publications of the Week The CXCL12-CXCR4/CXCR7 Axis as a Mechanism of Immune Resistance in Gastrointestinal MalignanciesDaniel, S.K., et al. | January 9, 2020Single agent checkpoint inhibitor therapy has not been effective for most gastrointestinal solid tumors, but…sciencecityJanuary 9, 2020 Read More
Publications of the Week Subcellular Drug Targeting Illuminates Local Kinase ActionBucko, P.J., et al. | January 8, 2020Deciphering how signaling enzymes operate within discrete microenvironments is fundamental to understanding biological processes. A-kinase…sciencecityJanuary 8, 2020 Read More
Publications of the Week Antibiotic-Induced Microbiome Perturbations Are Associated with Significant Alterations to Colonic Mucosal Immunity in Rhesus MacaquesManuzak, J.A., et al. | December 20, 2019The authors evaluated the effects of four specific antibiotics in healthy female rhesus macaques. All…sciencecityDecember 20, 2019 Read More
Publications of the Week Preemptive Mitigation of CD19 CAR T-Cell Cytokine Release Syndrome without Attenuation of Antileukemic EfficacyGardner, R.A., et al. | December 19, 2019Immunotherapy with the adoptive transfer of T cells redirected with CD19-specific chimeric antigen receptors (CARs)…sciencecityDecember 19, 2019 Read More
Publications of the Week Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through ImmunizationParks, K.R., et al. | December 12, 2019The authors report on a two-step immunization scheme that leads to the maturation of VRC01-like…sciencecityDecember 12, 2019 Read More
Publications of the Week Durable Preservation of Antiviral Antibodies After CD19-Directed Chimeric Antigen Receptor T-Cell ImmunotherapyHill, J.A., et al. | December 9, 2019The long-term effects of CD19-targeted chimeric antigen receptor–modified T-cell immunotherapy (CD19-CARTx) for B-cell malignancies on…sciencecityDecember 9, 2019 Read More
Publications of the Week A High-Resolution Landscape of Mutations in the BCL6 Super-Enhancer in Normal Human B CellsShen, J.C., et al. | December 4, 2019We used duplex sequencing to detect low-frequency mutations in the BCL6 super-enhancer locus in normal human B…sciencecityDecember 4, 2019 Read More
Publications of the Week RNA-Binding Protein Isoforms ZAP-S and ZAP-L Have Distinct Antiviral and Immune Resolution FunctionsSchwerk, J., et al. | December 2, 2019Robust inflammatory responses are essential to control microbial infections. At the same time, it is…sciencecityDecember 2, 2019 Read More