Publications of the Week Therapeutically Relevant Engraftment of a CRISPR-Cas9–Edited HSC-Enriched Population with HbF Reactivation in Nonhuman PrimatesHumbert, O., et al. | August 14, 2019The CRISPR/Cas9 technology offers many opportunities to treat genetic and infectious diseases, but safety of…sciencecityAugust 14, 2019 Read More
Publications of the Week The Androgen Receptor Regulates a Druggable Translational Regulon in Advanced Prostate CancerLiu, Y., et al. | August 12, 2019Most prostate cancers are initially addicted to androgens and the androgen receptor, which they use…sciencecityAugust 12, 2019 Read More
Publications of the Week Rethinking the Role of the Brain in Glucose Homeostasis and Diabetes PathogenesisBrown, J.M., et al. | August 9, 2019The brain plays a major role in homeostatic processes ranging from control of body temperature…sciencecityAugust 9, 2019 Read More
Publications of the Week Epitope Targeting with Self-Assembled Peptide VaccinesZeigler, D.F., et al. | August 7, 2019Nanoparticle-based delivery systems are being used to simplify and accelerate new vaccine development. Previously, we…sciencecityAugust 7, 2019 Read More
Publications of the Week High Prevalence and Disease Correlation of Autoantibodies against p40 Encoded by Long Interspersed Nuclear Elements (LINE-1) in Systemic Lupus ErythematosusCarter, V., et al. | August 5, 2019This paper describes evidence that a retroelement in our genome, called LINE-1, is active in…sciencecityAugust 5, 2019 Read More
Publications of the Week A Pro-Inflammatory CD8+ T-Cell Subset Patrols the Cervicovaginal TractPattacini, L., et al. | August 1, 2019The immune system of the cervicovaginal tract (CVT) must balance immunosurveillance and active immunity against…sciencecityAugust 1, 2019 Read More
Publications of the Week DUX4 Suppresses MHC Class I to Promote Cancer Immune Evasion and Resistance to Checkpoint BlockadeChew, G., et al. | July 30, 2019Advances in cancer immunotherapies make it critical to identify genes that modulate antigen presentation and…sciencecityJuly 30, 2019 Read More
Publications of the Week Human CD4+CD103+ Cutaneous Resident Memory T Cells are Found in the Circulation of Healthy IndividualsKlicznik, M.M., et al. | July 26, 2019Although T cells are abundant in the blood, these circulating T cells are not thought…sciencecityJuly 26, 2019 Read More
Publications of the Week Reprogramming Identifies Functionally Distinct Stages of Clonal Evolution in Myelodysplastic SyndromesHsu, J., et al. | July 24, 2019The authors show that episomal reprogramming of MDS and AML patient samples to iPSCs captures…sciencecityJuly 24, 2019 Read More
Publications of the Week Controlling Protein Assembly on Inorganic Crystals through Designed Protein InterfacesPyles, H., et al. | July 22, 2019Many hard biomaterials like bone and teeth get their exquisite material properties from protein–mineral interactions.…sciencecityJuly 22, 2019 Read More