Publications of the Week Aligning Single-Cell Developmental and Reprogramming Trajectories Identifies Molecular Determinants of Myogenic Reprogramming OutcomeCacchiarelli, D., et al. | September 27, 2018Cellular reprogramming through manipulation of defined factors holds great promise for large-scale production of cell…sciencecitySeptember 27, 2018 Read More
Publications of the Week Activated PIK3CD Drives Innate B Cell Expansion yet Limits B Cell-Intrinsic Immune ResponsesWray-Dutra, M.N., et al. | September 24, 2018Activated PI3K-delta syndrome (APDS) is an immunodeficiency caused by gain-of-function mutations in PIK3CD. This disease…sciencecitySeptember 24, 2018 Read More
Publications of the Week Receptive Field Center-Surround Interactions Mediate Context-Dependent Spatial Contrast Encoding in the RetinaTurner, M.H., et al. | September 20, 2018Antagonistic receptive field surrounds are a near-universal property of early sensory processing. A key assumption…sciencecitySeptember 20, 2018 Read More
Publications of the Week Chemical Cross-Linking with Mass Spectrometry: A Tool for Systems Structural BiologyChavez, J.D. and Bruce, J.E. | September 18, 2018Biological processes supporting life are orchestrated by a highly dynamic array of protein structures and…sciencecitySeptember 18, 2018 Read More
Publications of the Week Alveolar Macrophages Provide an Early Mycobacterium tuberculosis Niche and Initiate DisseminationCohen, S.B., et al. | September 14, 2018Mycobacterium tuberculosis (Mtb) infection is initiated in the distal airways, but the bacteria ultimately disseminate to…sciencecitySeptember 14, 2018 Read More
Publications of the Week Human T Cell Receptor Occurrence Patterns Encode Immune History, Genetic Background, and Receptor SpecificityDeWitt, W.S., et al. | September 10, 2018High-throughput DNA sequencing has enabled deep profiling of the set of receptors that T and…sciencecitySeptember 10, 2018 Read More
Publications of the Week Cas9 Immunity Creates Challenges for CRISPR Gene Editing TherapiesCrudele, J.M., et al. | September 5, 2018Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 is a genome-editing technology1,2 that utilizes archaeal and bacterial…sciencecitySeptember 5, 2018 Read More
Publications of the Week Early Cellular Innate Immune Responses Drive Zika Viral Persistence and Tissue Tropism in Pigtail MacaquesO'Connor, M.A., et al. | September 3, 2018The immunological and virological events that contribute to the establishment of Zika virus (ZIKV) infection…sciencecitySeptember 3, 2018 Read More
Publications of the Week An Assay for De Novo Kinetochore Assembly Reveals a Key Role for the CENP-T Pathway in Budding YeastLang, J., et al. | August 31, 2018Chromosome segregation depends on the kinetochore, the machine that establishes force-bearing attachments between DNA and…sciencecityAugust 31, 2018 Read More
Publications of the Week Viral Genetic Diversity and Protective Efficacy of a Tetravalent Dengue Vaccine in Two Phase 3 TrialsJuraska, M., et al. | August 29, 2018Two phase 3 placebo-controlled trials of the CYD-TDV vaccine, evaluated in children aged 2-14 y…sciencecityAugust 29, 2018 Read More