Publications of the Week Constitutive XBP-1s-Mediated Activation of the Endoplasmic Reticulum Unfolded Protein Response Protects against Pathological Tau Waldherr, S.M., et al. | October 15, 2019 To endure over the organismal lifespan, neurons utilize multiple strategies to achieve protein. To identify…sciencecityOctober 15, 2019 Read More
Publications of the Week N6-Methyladenosine mRNA Marking Promotes Selective Translation of Regulons Required for Human Erythropoiesis Kuppers, D.A., et al. | October 11, 2019 Many of the regulatory features governing erythrocyte specification, maturation, and associated disorders remain enigmatic. To…sciencecityOctober 11, 2019 Read More
Publications of the Week γ-Secretase Inhibition Increases Efficacy of BCMA-Specific Chimeric Antigen Receptor T Cells in Multiple Myeloma Pont, M., et al. | October 9, 2019 B cell maturation antigen (BCMA) is a validated target for chimeric antigen receptor (CAR) T…sciencecityOctober 9, 2019 Read More
Publications of the Week MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota Koyama, M., et al. | October 7, 2019 While the effector pathways that mediate graft-versus-host disease (GVHD) are well established (i.e. donor T…sciencecityOctober 7, 2019 Read More
Publications of the Week Suppression of Monosodium Urate Crystal-Induced Inflammation by Inhibiting TGF-β-Activated Kinase 1-Dependent Signaling: Role of the Ubiquitin Proteasome System Singh, A.K., et al. | October 3, 2019 Monosodium urate (MSU) crystals activate inflammatory pathways that overlap with interleukin-1β (IL-1β) signaling. However, the…sciencecityOctober 3, 2019 Read More
Publications of the Week Functional Metagenomics-Guided Discovery of Potent Cas9 Inhibitors in the Human Microbiome Forsberg, K.J., et al. | September 30, 2019 CRISPR-Cas systems protect bacteria and archaea from phages and other mobile genetic elements, which use…sciencecitySeptember 30, 2019 Read More
Publications of the Week A Lineage-Resolved Molecular Atlas of C. Elegans Embryogenesis at Single-Cell Resolution Packer, J.S., et al. | September 27, 2019 Single-cell RNA sequencing provides the power to identify the developmental trajectory of an organism. However,…sciencecitySeptember 27, 2019 Read More
Publications of the Week Tissue Chips in Space — Challenges and Opportunities Yeung, C.K., et al. | September 25, 2019 The microgravity environment results in a multitude of physiological changes associated with aging and altered…sciencecitySeptember 25, 2019 Read More
Publications of the Week Cell-Specific Image-Guided Transcriptomics Identifies Complex Injuries Caused by Ischemic Acute Kidney Injury in Mice Miyazaki, T., et al. | September 24, 2019 The highly heterogeneous nature of the kidney’s tubular epithelium has made it challenging to identify…sciencecitySeptember 24, 2019 Read More
Publications of the Week Mechanisms of Interplay between Transcription Factors and the 3D Genome Kim, S. & Shendure, J. | September 20, 2019 Transcription factors (TFs) bind DNA in a sequence-specific manner and thereby serve as the protein…sciencecitySeptember 20, 2019 Read More