Publications of the Week Zebrafish Cutaneous Injury Models Reveal That Langerhans Cells Engulf Axonal Debris in Adult EpidermisPeterman, E., et al. | January 2, 2024Somatosensory neurons extend enormous peripheral axons to the skin, where they detect diverse environmental stimuli.…karnottJanuary 2, 2024 Read More
Publications of the Week Targeting the Fibroblast Growth Factor Pathway in Molecular Subtypes of Castration-Resistant Prostate CancerLabrecque, M., et al. | December 14, 2023Androgen receptor (AR) pathway inhibition remains the cornerstone for prostate cancer therapies. However, castration-resistant prostate…karnottDecember 14, 2023 Read More
Publications of the Week A First-in-Human, Open-Label Phase 1b and a Randomised, Double-Blind Phase 2a Clinical Trial in Recent-Onset Type 1 Diabetes with AG019 As Monotherapy and in Combination with TeplizumabMathieu, C., et al. | December 13, 2023We hypothesised that islet beta cell antigen presentation in the gut along with a tolerising…karnottDecember 13, 2023 Read More
Publications of the Week A Standard Workflow for Community-Driven Manual Curation of Strongyloides Genome AnnotationsBryant, A., et al. | December 8, 2023Advances in the functional genomics and bioinformatics toolkits for Strongyloides species have positioned these species as genetically…karnottDecember 8, 2023 Read More
Publications of the Week Expression of the Vesicular GABA Transporter within Neuromedin S+ Neurons Sustains Behavioral Circadian RhythmsBussi, I.L., et al. | December 5, 2023The suprachiasmatic nucleus (SCN) of the hypothalamus is the site of a central circadian clock…sciencecityDecember 5, 2023 Read More
Publications of the Week Flipped C-Terminal Ends of ApoA1 Promote ABCA1-Dependent Cholesterol Efflux by Small HDLsHe, Y., et al. | December 1, 2023Cholesterol efflux capacity (CEC) predicts cardiovascular disease independently of high-density lipoprotein (HDL) cholesterol levels. Isolated…sciencecityDecember 1, 2023 Read More
Publications of the Week Multi-Omic Analysis of Human Kidney Tissue Identified Medulla-Specific Gene Expression PatternsHaug, S., et al. | November 29, 2023The kidney medulla is a specialized region with important homeostatic functions. It has been implicated…sciencecityNovember 29, 2023 Read More
Publications of the Week T Cell Receptor Sequences Are the Dominant Factor Contributing to the Phenotype of CD8+ T Cells with Specificities Against Immunogenic Viral AntigensChen, D., et al. | November 24, 2023This week, Science in Seattle profiles Dr. Jim Heath (pictured). Dr. Heath is President and…karnottNovember 24, 2023 Read More
Publications of the Week Probing Cerebral Malaria Inflammation in 3D Human Brain MicrovesselsHoward, C., et al. | November 23, 2023Sequestration of Plasmodium falciparum-infected erythrocytes (IEs) in the brain microcirculation is a hallmark of cerebral…karnottNovember 23, 2023 Read More
Publications of the Week Embryo-Scale Reverse Genetics at Single-Cell ResolutionSaunders, L., et al. | November 22, 2023The maturation of single-cell transcriptomic technologies has facilitated the generation of comprehensive cellular atlases from…karnottNovember 22, 2023 Read More