Publications of the Week Targeting FZD6 Creates Therapeutically Actionable Vulnerabilities for Advanced Prostate Cancer Li, Y., et al. | December 4, 2025 Wnt signaling is a complex pathway consisting of numerous ligands and frizzled (FZD) receptors. These…karnottDecember 4, 2025 Read More
Publications of the Week Drug Screening in 3D Microtumors Reveals DDR1/2-MAPK12-GLI1 as a Vulnerability in Cancer-Associated Fibroblasts Nishida-Aoki, N., et al. | November 28, 2025 Interactions between cancer cells and surrounding stromal cells are critical for tumor biology and treatment…karnottNovember 28, 2025 Read More
Publications of the Week Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography Imaging as a Precision Diagnostic at Prostate Cancer Recurrence After Radical Prostatectomy: Modeling Long-Term Survival Gogebakan, K., et al. | November 20, 2025 Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA-PET/CT) is affecting the management of patients with…karnottNovember 20, 2025 Read More
Publications of the Week The New Frontier in Understanding Human and Mammalian Brain Development Nowakowski, T., et al. | November 13, 2025 Neurodevelopmental disorders that cause cognitive, behavioural or motor impairments affect around 15% of children and…karnottNovember 13, 2025 Read More
Publications of the Week Atomically Accurate De Novo Design of Antibodies With RFdiffusion Bennett, N., et al. | November 13, 2025 Despite the central role of antibodies in modern medicine, no method currently exists to design…karnottNovember 13, 2025 Read More
Publications of the Week Bottom-up Design of CA2+ Channels From Defined Selectivity Filter Geometry Liu, Y., et al. | November 5, 2025 Native ion channels play key roles in biological systems, and engineered versions are widely used…karnottNovember 5, 2025 Read More
Publications of the Week Multi-Omic Profiling Reveals Age-Related Immune Dynamics in Healthy Adults Gong, M., et al. | November 3, 2025 The generation and maintenance of immunity is a dynamic process that is dependent on age1,2,3.…karnottNovember 3, 2025 Read More
Publications of the Week Selective Presynaptic Inhibition of Leg Proprioception in Behaving Drosophila Dallmann, C., et al. | October 30, 2025 Controlling arms and legs requires feedback from the proprioceptive sensory neurons that detect joint position…karnottOctober 30, 2025 Read More
Publications of the Week Computationally Designed mRNA-Launched Protein Nanoparticle Immunogens Elicit Protective Antibody and T Cell Responses in Mice Hendricks, G., et al. | October 28, 2025 The first generation of mRNA vaccines for SARS-CoV-2 was instrumental in curbing the ongoing COVID-19…karnottOctober 28, 2025 Read More
Publications of the Week Microtubules Regulate Tissue-Level Navigation in Skin-Resident Macrophages Peterman, E., et al. | October 21, 2025 Specialised macrophages called Langerhans cells respond rapidly to skin damage, migrating to wounds to promote…karnottOctober 21, 2025 Read More