Publications of the Week Analysis of the HVTN 702 Phase 2b-3 HIV-1 Vaccine Trial in South Africa Assessing RV144 Antibody and T Cell Correlates of HIV-1 Acquisition RiskMoodie, Z., et al. | July 14, 2022Read the Publication This week we profile a recent publication in The Journal of Infectious…dcorriganJuly 14, 2022 Read More
Publications of the Week Development of a Primary Human Intestinal Epithelium Enriched in L-Cells for Assay of GLP-1 SecretionVillegas-Novoa, C., et al. | July 8, 2022Type 2 diabetes mellitus is a chronic disease associated with obesity and dysregulated human feeding…dcorriganJuly 8, 2022 Read More
Publications of the Week Mapping Functional Regions of Essential Bacterial Proteins with Dominant-Negative Protein FragmentsSavinov, A., Fernandez, A., and Fields, S. | July 7, 2022Peptide fragments can inhibit the interactions of the full-length proteins from which the fragments derive. The…dcorriganJuly 7, 2022 Read More
Publications of the Week Guselkumab Provides Sustained Domain-Specific and Comprehensive Efficacy Using Composite Indices in Patients with Active Psoriatic ArthritisCoates, L. C., et al. | July 1, 2022The authors evaluate the efficacy of guselkumab for the treatment of active psoriatic arthritis (PsA)…dcorriganJuly 1, 2022 Read More
Publications of the Week Shifting Mutational Constraints in the SARS-CoV-2 Receptor-Binding Domain during Viral EvolutionScience | June 29, 2022SARS-CoV-2 has evolved variants with substitutions in the spike receptor-binding domain (RBD) that impact its…dcorriganJune 29, 2022 Read More
Publications of the Week Chemical Exploration of a Highly Selective Scaffold with Activity against Intracellular Mycobacterium tuberculosisNjikan, S., et al. | June 23, 2022The authors previously identified a phenylthiourea series with activity against intracellular Mycobacterium tuberculosis using a high-throughput,…dcorriganJune 23, 2022 Read More
Publications of the Week Blockade of Interleukin 10 Potentiates Antitumor Immune Function in Human Colorectal Cancer Liver MetastasesSullivan, K. M., et al. | June 21, 2022The authors' central goal is to address is how the immunosuppressive microenvironment created by solid…dcorriganJune 21, 2022 Read More
Publications of the Week Succinate Metabolism in the Retinal Pigment Epithelium Uncouples Respiration from ATP SynthesisHass, D. T., et al. | June 17, 2022Fumarate can be a surrogate for O2 as a terminal electron acceptor in the electron transport…dcorriganJune 17, 2022 Read More
Publications of the Week Chemokines, Soluble PD-L1, and Immune Cell Hyporesponsiveness are Distinct Features of SARS-CoV-2 Critical IllnessMorrell, E. D., et al. | June 16, 2022Critically ill patients manifest many of the same immune features seen in COVID-19, including both…dcorriganJune 16, 2022 Read More
Publications of the Week TNF-α/IFN-γ Synergy Amplifies Senescence-Associated Inflammation and SARS-CoV-2 Receptor Expression via Hyper-Activated JAK/STAT1Kandhaya-Pillai, R., et al. | June 10, 2022Older age and underlying conditions such as diabetes/obesity or immunosuppression are leading host risk factors…pthomsonJune 10, 2022 Read More