Publications of the Week Blockade of TGF-β (Transforming Growth Factor Beta) Signaling by Deletion of Tgfbr2 in Smooth Muscle Cells of 11-Month-Old Mice Alters Aortic Structure and Causes Vasomotor DysfunctionLee, C. Y., et al. | May 12, 2022The authors showed that TGF-β signaling in smooth muscle cells during embryogenesis and early postnatal…dcorriganMay 12, 2022 Read More
Publications of the Week Development of [211At]astatine-Based Anti-CD123 Radioimmunotherapy for Acute Leukemias and Other CD123+ MalignanciesLaszlo, G. S., et al. | May 6, 2022Read the Publication This week we profile a recent publication in Leukemia from Dr. George…dcorriganMay 6, 2022 Read More
Publications of the Week Simultaneous Brain Cell Type and Lineage Determined by scRNA-Seq Reveals Stereotyped Cortical DevelopmentAnderson, D. J., et al. | May 2, 2022The authors show that a commonly occurring type of somatic mutation, loss of heterozygosity (LOH),…dcorriganMay 2, 2022 Read More
Publications of the Week Autocrine and Paracrine IL-2 Signals Collaborate to Regulate Distinct Phases of CD8 T Cell MemoryToumi, R., et al. | April 28, 2022Differential interleukin-2 (IL-2) signaling and production are associated with disparate effector and memory fates. Whether…dcorriganApril 28, 2022 Read More
Publications of the Week Human Cerebellar Development and Transcriptomics: Implications for Neurodevelopmental DisordersHaldipur, P., Millen, K. J., and Aldinger, K. A. | April 28, 2022Developmental abnormalities of the cerebellum are among the most recognized structural brain malformations in human…dcorriganApril 28, 2022 Read More
Publications of the Week Neoantigen-Specific CD4+ T Cells in Human Melanoma Have Diverse Differentiation States and Correlate with CD8+ T Cell, Macrophage, and B Cell FunctionVeatch, J., et al. | April 22, 2022The authors show that only a subset of the CD4+ T cells that are present…dcorriganApril 22, 2022 Read More
Publications of the Week BRCA1/BARD1 Is a Nucleosome Reader and WriterWitus, S. R., et al. | April 21, 2022Mutations in BRCA1 and BARD1 predispose carriers to breast and ovarian cancers. The BRCA1 and BARD1 proteins form a…dcorriganApril 21, 2022 Read More
Publications of the Week Familial Long-Read Sequencing Increases Yield of De Novo MutationsNoyes, M. D., et al. | April 15, 2022Studies of de novo mutation (DNM) have typically excluded some of the most repetitive and complex regions…dcorriganApril 15, 2022 Read More
Publications of the Week CRISPR/Cas9-Mediated Insertion of HIV Long Terminal Repeat within BACH2 Promotes Expansion of T Regulatory–Like CellsChristian, M. L., et al. | April 15, 2022One key barrier to curative therapies for HIV is the limited understanding of HIV persistence.…dcorriganApril 15, 2022 Read More
Publications of the Week Engineering a Niche Supporting Hematopoietic Stem Cell Development Using Integrated Single-Cell TranscriptomicsHadland, B., et al. | April 8, 2022The authors used single-cell RNA-sequencing to simultaneously study the transcriptomes of newly forming embryonic hematopoietic…dcorriganApril 8, 2022 Read More