Publications of the Week Therapeutic Targeting PRAME with mTCRCAR T Cells in Acute Myeloid LeukemiaKirkey, D. C., et al. | September 15, 2022Preferentially Expressed Antigen in Melanoma (PRAME) , a cancer testes antigen provides an ideal target…dcorriganSeptember 15, 2022 Read More
Publications of the Week Ablating Lgr5-Expressing Prostatic Stromal Cells Activates the ERK-Mediated Mechanosensory Signaling and Disrupts Prostate Tissue HomeostasisWei, Z., et al. | September 12, 2022Functional implication of stromal heterogeneity in the prostate remains incompletely understood. Using lineage tracing and…dcorriganSeptember 12, 2022 Read More
Publications of the Week Clinical Trial Development in TP53-Mutated Locally Advanced and Recurrent/Metastatic Head and Neck Squamous Cell CarcinomaRodriguez, C. P., et al. | September 9, 2022TP53 mutation is the most frequent genetic event in head and neck squamous cell carcinoma…dcorriganSeptember 9, 2022 Read More
Publications of the Week Upregulated PD-1 Signaling Antagonizes Glomerular Health in Aged Kidneys and DiseasePippin, J. W., et al. | September 7, 2022With an aging population, kidney health becomes an important medical and socioeconomic factor. Kidney aging…dcorriganSeptember 7, 2022 Read More
Publications of the Week IgM Antibodies Derived from Memory B Cells Are Potent Cross-Variant Neutralizers of SARS-CoV-2Hale, M., et al. | September 2, 2022Humoral immunity to SARS-CoV-2 can be supplemented with polyclonal sera from convalescent donors or an…dcorriganSeptember 2, 2022 Read More
Publications of the Week A Single-Cell Based Precision Medicine Approach Using Glioblastoma Patient-Specific ModelsPark, J. H., et al. | August 26, 2022Glioblastoma (GBM) is a heterogeneous tumor made up of cell states that evolve over time.…dcorriganAugust 26, 2022 Read More
Publications of the Week New Immuno-Oncology Targets and Resistance MechanismsTakez, M. C., et al. | August 25, 2022Immune checkpoint inhibition (ICI) has revolutionized the field of non-small cell lung cancer (NSCLC); currently,…pthomsonAugust 25, 2022 Read More
Publications of the Week Tissue Oxygenation Stabilizes Neovessels and Mitigates Hemorrhages in Human Atherosclerosis-Induced AngiogenesisA. C. Aplin & R. F. Nicosia | August 17, 2022The authors used novel ex vivo and in vivo models to characterize the effect of…dcorriganAugust 17, 2022 Read More
Publications of the Week Bladder Cancer Patient-Derived Organoids and Avatars for Personalized Cancer DiscoverySoo Kim, Y., Hsieh, A. C., and Lam, H. M. | August 16, 2022Prediction of treatment response has attracted growing attention in cancer research to improve clinical outcomes…dcorriganAugust 16, 2022 Read More
Publications of the Week Discovery of a Transferrin Receptor 1-Binding Aptamer and Its Application in Cancer Cell Depletion for Adoptive T Cell Therapy ManufacturingCheng, E. L., et al. | August 12, 2022The authors report a new high-affinity aptamer that binds to the transferrin receptor, also called…dcorriganAugust 12, 2022 Read More